Blnk MGI Mouse Gene Detail - MGI:96878 - B cell linker

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Blnk Gene Detail
Summary
  • Symbol
    Blnk
  • Name
    B cell linker
  • Synonyms
    BASH, Bca, BCA, BLNK, Ly-57, Ly57, SLP-65
  • Feature Type
    protein coding gene
  • IDs
    MGI:96878
    NCBI Gene: 17060
  • Alliance
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:40917371-40982664 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 19, 34.26 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2322 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96878
protein coding gene Chr19:40917371-40982978 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025117
protein coding gene Chr19:40178964-40246742 (-)
A/J MGP_AJ_G0025094
protein coding gene Chr19:38234385-38298007 (-)
AKR/J MGP_AKRJ_G0025062
protein coding gene Chr19:39512776-39581735 (-)
BALB/cJ MGP_BALBcJ_G0025088
protein coding gene Chr19:38298772-38367334 (-)
C3H/HeJ MGP_C3HHeJ_G0024848
protein coding gene Chr19:39655231-39720910 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025532
protein coding gene Chr19:41259580-41330028 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022945
protein coding gene Chr19:37614908-37680209 (-)
CAST/EiJ MGP_CASTEiJ_G0024313
protein coding gene Chr19:39288935-39357176 (-)
CBA/J MGP_CBAJ_G0024828
protein coding gene Chr19:43262266-43336726 (-)
DBA/2J MGP_DBA2J_G0024960
protein coding gene Chr19:38112669-38178419 (-)
FVB/NJ MGP_FVBNJ_G0024921
protein coding gene Chr19:37865577-37930297 (-)
LP/J MGP_LPJ_G0025046
protein coding gene Chr19:40197828-40268259 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024952
protein coding gene Chr19:42933061-43002061 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025589
protein coding gene Chr19:39539958-39605329 (-)
PWK/PhJ MGP_PWKPhJ_G0024063
protein coding gene Chr19:37961020-38026296 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023866
protein coding gene Chr19:38279955-38350913 (-)
WSB/EiJ MGP_WSBEiJ_G0024383
protein coding gene Chr19:39703177-39773158 (-)



Homology
more
  • Human Ortholog
    BLNK, B cell linker
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BLNK, B cell linker
  • Synonyms
    AGM4, BASH, bca, BLNK-S, LY57, SLP-65, SLP65
  • Links
    NCBI Gene ID: 29760
    UniProt: Q8WV28

  • Chr Location
    10q24.1; chr10:96189171-96271587 (-) GRCh38
Human Diseases
more
  • Diseases
    2 with human BLNK associations

Human Disease Mouse Models
IDs
agammaglobulinemia

DOID:2583
DOID:618
ICD10CM:D80.1
ICD9CM:279.00
MESH:D000361
NCI:C26931
OMIM:PS601495
UMLS_CUI:C0001768
UMLS_CUI:C0086438
IDs
agammaglobulinemia 4
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    44 phenotypes from 6 alleles in 8 genetic backgrounds
    39 phenotypes from multigenic genotypes
    61 phenotype references
Phenotype Overview

Phenotype Overview
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.
adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit a partial block in pre-B cell development, a lack of B1 B cells, reduced numbers of mature B cells, lower IgM and IgG3 serum levels, poor IgM immune responses, and a high incidence of pre-B cell lymphoma.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
  • Blue cells = expressed in wild-type.
    Gray triangles = other expression annotations only
    (e.g. absence of expression or data from mutants).
early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
    3
  • Comparison Matrix
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17060 NCBI Gene Model | MGI Sequence Detail 65294 C57BL/6J ± kb
    transcript NM_008528 RefSeq | MGI Sequence Detail 1783 ZRU/MplStud
    polypeptide Q9QUN3 UniProt | EBI | MGI Sequence Detail 457 Not Applicable
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 17
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11999, MGD-MRK-12042, MGI:1278314
    References
    more
    • Summaries
      All 113
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 10
      Phenotypes 61
    • Earliest
      J:2171 Rochelle JM, et al., A linkage map of mouse chromosome 19: definition of comparative mapping relationships with human chromosomes 10 and 11 including the MEN1 locus. Genomics. 1992 Sep;14(1):26-31
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    TSS for Blnk:
    (View these features in JBrowse)
    Transcription Start Site Location Distance from Gene 5'-end
    Tssr159238 Chr19:40984564-40984579 (-) -1,908 bp
    Tssr159237 Chr19:40982721-40982732 (-) -63 bp
    Tssr159236 Chr19:40982697-40982715 (-) -42 bp
    Tssr159235 Chr19:40982654-40982670 (-) 2 bp
    Tssr159234 Chr19:40982632-40982643 (-) 26 bp
    Tssr159233 Chr19:40982598-40982624 (-) 53 bp
    Tssr159232 Chr19:40982576-40982587 (-) 82 bp
    Tssr159231 Chr19:40965520-40965532 (-) 17,138 bp
    Tssr159230 Chr19:40948194-40948206 (-) 34,464 bp
    Tssr159229 Chr19:40948169-40948186 (-) 34,486 bp
    Tssr159228 Chr19:40944048-40944071 (-) 38,604 bp
    Tssr159227 Chr19:40944006-40944035 (-) 38,643 bp
    Tssr159226 Chr19:40942467-40942477 (-) 40,192 bp
    Tssr159225 Chr19:40941777-40941798 (-) 40,876 bp
    Tssr159224 Chr19:40928661-40928673 (-) 53,997 bp
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support. last database update
    10/07/2025
    MGI 6.24 The Jackson Laboratory
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