Lef1 MGI Mouse Gene Detail - MGI:96770 - lymphoid enhancer binding factor 1

Summary

• Symbol
  Lef1
• Name
  lymphoid enhancer binding factor 1
• Synonyms
  Lef-1, lymphoid enhancer factor 1

• Feature Type
  protein coding gene
• IDs
  MGI:96770
  NCBI Gene: 16842
• Alliance
  gene page
• Transcription Start Sites
  43 TSS

Location &
Maps

• Sequence Map
  Chr3:130904120-131018005 bp, + strand

  From Ensembl annotation of GRCm39
  
• View this region in JBrowse
  
• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 3, 60.78 cM
• Mapping Data
  8 experiments

Strain
Comparison

• SNPs within 2kb
  3509 from dbSNP Build 142
• Strain Annotations
  18
• RFLP
  1

Homology

• Human Ortholog
  LEF1, lymphoid enhancer binding factor 1

• Vertebrate Orthologs
  3

Human Diseases

• Diseases
  1 with human LEF1 associations

Human Disease	Mouse Models
ovarian cancer IDs ovarian cancer DOID:2394 DOID:0060070 DOID:2144 DOID:9595 ICD10CM:C56 ICD9CM:183.0 MESH:D010051 NCI:C4984 NCI:C7431 OMIM:167000 OMIM:607893 ORDO:213500 ORDO:213517 UMLS_CUI:C0919267 UMLS_CUI:C1140680 UMLS_CUI:C1299247

Click on a disease name to see all genes associated with that disease.

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  52 phenotypes from 5 alleles in 7 genetic backgrounds
  14 phenotypes from multigenic genotypes
  101 phenotype references
  

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

• All Mutations and Alleles
  22
• Chemically induced (other)
  1
• Endonuclease-mediated
  5
• Gene trapped
  4
• Radiation induced
  1
• Targeted
  9
• Transgenic
  2
• Genomic Mutations
  2 involving Lef1
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  42 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Mice homozygous for a null allele are small and die postnatally showing lack of teeth, mammary and uterine glands, whiskers, body hair, dermal-associated fat, and a dentate gyrus, as well as defects in hippocampus morphology, hair follicle development, retinal vasculature, and vascular regression.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  193
• GO References
  61

Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

• Blue cells = expressed in wild-type.
  Gray triangles = other expression annotations only
  (e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

• Assay Results
  2321
• Tissues
  868
• cDNA Data
  75
• Literature Summary
  522

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GENSAT
  GEO
  Expression Atlas
• Other Vertebrate Links
  GEISHA LEF1
  Xenbase lef1
  ZFIN lef1

Sequences &
Gene Models

• All Sequences
  75
• RefSeq
  22
• UniProt
  6
• CCDS
  CCDS17842.1, CCDS71319.1, CCDS71320.1

• Ensembl
  ENSMUSG00000027985 (Evidence)
• NCBI Gene
  16842

Representative Sequences				Length	Strain/Species	Flank
	genomic	ENSMUSG00000027985	Ensembl Gene Model | MGI Sequence Detail	113886	C57BL/6J	± kb
	transcript	ENSMUST00000029611	Ensembl | MGI Sequence Detail	3482	Not Applicable
	polypeptide	ENSMUSP00000029611	Ensembl | MGI Sequence Detail	397	Not Applicable

For the selected sequence download in FASTA format forward to NCBI BLAST

Protein
Information

• UniProt
  6 Sequences
• Protein Ontology
  PR:000009751 lymphoid enhancer-binding factor 1
  (term hierarchy)
• PDB
  2LEF, 3OUW, 3OUX
• InterPro Domains
  IPR027397 Catenin binding domain superfamily
  IPR013558 CTNNB1 binding, N-teminal
  IPR009071 High mobility group box domain
  IPR036910 High mobility group box domain superfamily
  IPR024940 Transcription factor TCF/LEF
• GlyGen
  P27782 1 site

Molecular
Reagents

• All nucleic 146

  Genomic 1

  cDNA 82

  Primer pair 32

  Other 31

  
  

  Microarray probesets 5

Other
Accession IDs

References

• Summaries
  All 711

  Developmental Gene Expression 522

  Diseases 1

  Gene Ontology 61

  Phenotypes 101
• Earliest
  J:10393 Mattei MG, et al., Chromosomal localization of the three members of the jun proto-oncogene family in mouse and man. Oncogene. 1990 Jan;5(1):151-6
• Latest
  J:371530 Parichha A, et al., An evolutionarily conserved role for CTNNB1/beta-CATENIN in regulating the development of the corpus callosum. iScience. 2025 Sep 19;28(9):113335

TSS for Lef1:

(View these features in JBrowse)