Grin2b MGI Mouse Gene Detail - MGI:95821 - glutamate receptor, ionotropic, NMDA2B (epsilon 2)

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Grin2b Gene Detail
Summary
  • Symbol
    Grin2b
  • Name
    glutamate receptor, ionotropic, NMDA2B (epsilon 2)
  • Synonyms
    GluN2B, GluRepsilon2, Nmdar2b, NMDAR2B, NR2B
  • Feature Type
    protein coding gene
  • IDs
    MGI:95821
    NCBI Gene: 14812
  • Alliance
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:135690231-136150509 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 6, 66.38 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    14419 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95821
protein coding gene Chr6:135690219-136150658 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031420
protein coding gene Chr6:140074020-140556007 (-)
A/J MGP_AJ_G0031396
protein coding gene Chr6:134539702-135007677 (-)
AKR/J MGP_AKRJ_G0031323
protein coding gene Chr6:138631772-139099002 (-)
BALB/cJ MGP_BALBcJ_G0031402
protein coding gene Chr6:134390829-134870793 (-)
C3H/HeJ MGP_C3HHeJ_G0031124
protein coding gene Chr6:138677503-139155504 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031863
protein coding gene Chr6:143913859-144406732 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028994
protein coding gene Chr6:133702578-134169528 (-)
CAST/EiJ MGP_CASTEiJ_G0030493
protein coding gene Chr6:138148336-138629638 (-)
CBA/J MGP_CBAJ_G0031083
protein coding gene Chr6:149247661-149754245 (-)
DBA/2J MGP_DBA2J_G0031241
protein coding gene Chr6:133405408-133865026 (-)
FVB/NJ MGP_FVBNJ_G0031191
protein coding gene Chr6:132314222-132779995 (-)
LP/J MGP_LPJ_G0031325
protein coding gene Chr6:140161570-140642120 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031231
protein coding gene Chr6:153235534-153718148 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031895
protein coding gene Chr6:138400312-138884281 (-)
PWK/PhJ MGP_PWKPhJ_G0030218
protein coding gene Chr6:131914539-132381629 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030042
protein coding gene Chr6:136604417-137103529 (-)
WSB/EiJ MGP_WSBEiJ_G0030584
protein coding gene Chr6:139030704-139517431 (-)



Homology
more
  • Human Ortholog
    GRIN2B, glutamate ionotropic receptor NMDA type subunit 2B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRIN2B, glutamate ionotropic receptor NMDA type subunit 2B
  • Synonyms
    DEE27, EIEE27, GluN2B, hNR3, MRD6, NMDAR2B, NR2B, NR3
  • Links
    NCBI Gene ID: 2904
    UniProt: Q13224

  • Chr Location
    12p13.1; chr12:13437942-13982134 (-) GRCh38
Human Diseases
more
  • Diseases
    9 with human GRIN2B associations

Human Disease Mouse Models
IDs
alcohol use disorder

DOID:1574
ICD10CM:F10.1
ICD9CM:305.0
ICD9CM:305.00
MESH:D000437
NCI:C20701
UMLS_CUI:C0085762
IDs
Alzheimer's disease

DOID:10652
ICD10CM:G30
ICD9CM:331.0
KEGG:05010
MESH:D000544
NCI:C2866
UMLS_CUI:C0002395
IDs
autosomal dominant intellectual developmental disorder 6
IDs
bipolar disorder

DOID:3312
DOID:3311
DOID:9554
DOID:9555
ICD10CM:F31
ICD9CM:296.40
ICD9CM:296.60
ICD9CM:296.80
MESH:D001714
NCI:C34423
NCI:C34424
NCI:C34805
UMLS_CUI:C0005586
UMLS_CUI:C0005587
UMLS_CUI:C0024713
UMLS_CUI:C0236780
IDs
chronic obstructive pulmonary disease

DOID:3083
DOID:11500
DOID:6144
EFO:0000341
ICD10CM:J44.9
MESH:D029424
NCI:C3199
OMIM:606963
UMLS_CUI:C0024117
IDs
developmental and epileptic encephalopathy 27
IDs
Huntington's disease

DOID:12858
ICD10CM:G10
ICD9CM_2006:333.4
ICD9CM:333.4
KEGG:05016
MESH:D006816
NCI:C82342
OMIM:143100
UMLS_CUI:C0020179
IDs
nicotine dependence

DOID:0050742
EFO:0003768
ICD10CM:F17
MESH:D014029
NCI:C54203
UMLS_CUI:C0028043
IDs
schizophrenia

DOID:5419
DOID:14734
ICD10CM:F20
ICD9CM:295
ICD9CM:295.8
ICD9CM:295.80
ICD9CM:295.9
ICD9CM:295.90
MESH:D012559
NCI:C3362
OMIM:181500
UMLS_CUI:C0036341
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    59 phenotypes from 11 alleles in 12 genetic backgrounds
    21 phenotypes from multigenic genotypes
    113 phenotype references
Phenotype Overview

Phenotype Overview
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.
adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit impairments in suckling, hippocampal long term depression, and pattern formation of trigeminal nucleus sensory afferent terminals. Mutants die shortly after birth. Kinase-dead mutants display ant-depressive behavior.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
  • Blue cells = expressed in wild-type.
    Gray triangles = other expression annotations only
    (e.g. absence of expression or data from mutants).
early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030209 Ensembl Gene Model | MGI Sequence Detail 460279 C57BL/6J ± kb
    transcript ENSMUST00000053880 Ensembl | MGI Sequence Detail 24060 Not Applicable
    polypeptide ENSMUSP00000062284 Ensembl | MGI Sequence Detail 1482 Not Applicable
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000008247 glutamate receptor ionotropic, NMDA 2B
    • InterPro Domains
      IPR018884 Glutamate [NMDA] receptor, epsilon subunit, C-terminal
      IPR015683 Ionotropic glutamate receptor
      IPR001320 Ionotropic glutamate receptor, C-terminal
      IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
      IPR001508 Ionotropic glutamate receptor, metazoa
      IPR028082 Periplasmic binding protein-like I
      IPR001828 Receptor, ligand binding region
    • GlyGen
      Q01097 18 sites, 18 N-linked glycans (15 sites), 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 31
      Genomic 1
      cDNA 23
      Primer pair 3
      Other 4

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-10259, MGD-MRK-12900, MGI:2141680
    References
    more
    • Summaries
      All 384
      Developmental Gene Expression 71
      Gene Ontology 77
      Phenotypes 113
    • Earliest
      J:1333 Kutsuwada T, et al., Molecular diversity of the NMDA receptor channel [see comments]. Nature. 1992 Jul 2;358(6381):36-41
    • Latest
      J:373117 Perzel Mandell KA, et al., Meta-analysis of the brain transcriptomes of multiple genetic mouse models of schizophrenia highlights dysregulation in striatum and thalamus. Transl Psychiatry. 2025 Sep 29;15(1):345
    TSS for Grin2b:
    (View these features in JBrowse)
    Transcription Start Site Location Distance from Gene 5'-end
    Tssr63796 Chr6:136150636-136150653 (-) -136 bp
    Tssr63795 Chr6:136150528-136150548 (-) -29 bp
    Tssr63794 Chr6:136150490-136150521 (-) 3 bp
    Tssr63793 Chr6:136150270-136150301 (-) 223 bp
    Tssr63792 Chr6:136150092-136150147 (-) 389 bp
    Tssr63791 Chr6:136150078-136150091 (-) 424 bp
    Tssr63781 Chr6:136148511-136148522 (-) 1,992 bp
    Tssr63780 Chr6:135980452-135980460 (-) 170,053 bp
    Tssr63779 Chr6:135980413-135980424 (-) 170,090 bp
    Tssr63778 Chr6:135710663-135710670 (-) 439,842 bp
    Tssr63777 Chr6:135710605-135710614 (-) 439,899 bp
    Tssr63776 Chr6:135710585-135710599 (-) 439,917 bp
    Tssr63775 Chr6:135709760-135709765 (-) 440,746 bp
    Tssr63774 Chr6:135708261-135708265 (-) 442,246 bp
    Tssr63773 Chr6:135706859-135706878 (-) 443,640 bp
    Tssr63772 Chr6:135702566-135702578 (-) 447,937 bp
    Tssr63771 Chr6:135701740-135701747 (-) 448,765 bp
    Tssr63770 Chr6:135698755-135698766 (-) 451,748 bp
    Tssr63769 Chr6:135695686-135695718 (-) 454,807 bp
    Tssr63768 Chr6:135690439-135690470 (-) 460,054 bp
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support. last database update
    10/07/2025
    MGI 6.24 The Jackson Laboratory
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