Drd5 MGI Mouse Gene Detail - MGI:94927 - dopamine receptor D5

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Drd5 Gene Detail
Summary
  • Symbol
    Drd5
  • Name
    dopamine receptor D5
  • Synonyms
    D5R, Drd1b, DRD1b, Drd-5, Gpcr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:94927
    NCBI Gene: 13492
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:38476742-38479868 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 5, 20.40 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    185 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_94927
protein coding gene Chr5:38476710-38479868 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029511
protein coding gene Chr5:36728085-36731236 (+)
A/J MGP_AJ_G0029477
protein coding gene Chr5:35503448-35506601 (+)
AKR/J MGP_AKRJ_G0029427
protein coding gene Chr5:36835560-36838715 (+)
BALB/cJ MGP_BALBcJ_G0029488
protein coding gene Chr5:35992616-35995768 (+)
C3H/HeJ MGP_C3HHeJ_G0029211
protein coding gene Chr5:36824422-36827572 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029942
protein coding gene Chr5:38670885-38674036 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027180
protein coding gene Chr5:33176364-33179526 (+)
CAST/EiJ MGP_CASTEiJ_G0028619
protein coding gene Chr5:35995044-35998203 (+)
CBA/J MGP_CBAJ_G0029178
protein coding gene Chr5:39587686-39593509 (+)
DBA/2J MGP_DBA2J_G0029325
protein coding gene Chr5:35624311-35627462 (+)
FVB/NJ MGP_FVBNJ_G0029284
protein coding gene Chr5:35107126-35110284 (+)
LP/J MGP_LPJ_G0029411
protein coding gene Chr5:37177893-37181044 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029314
protein coding gene Chr5:40307057-40310208 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029975
protein coding gene Chr5:36323406-36326552 (+)
PWK/PhJ MGP_PWKPhJ_G0028343
protein coding gene Chr5:34791132-34794271 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028177
protein coding gene Chr5:35772689-35775836 (+)
WSB/EiJ MGP_WSBEiJ_G0028700
protein coding gene Chr5:36403546-36406694 (+)



Homology
more
  • Human Ortholog
    DRD5, dopamine receptor D5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DRD5, dopamine receptor D5
  • Synonyms
    DBDR, DRD1B, DRD1L2
  • Links
    NCBI Gene ID: 1816
    UniProt: P21918

  • Chr Location
    4p16.1; chr4:9781634-9784009 (+) GRCh38
Human Diseases
more
  • Diseases
    2 with human DRD5 associations

Human Disease Mouse Models
IDs
attention deficit hyperactivity disorder
IDs
blepharospasm

DOID:529
ICD10CM:G24.5
ICD9CM:333.81
MESH:D001764
NCI:C118723
UMLS_CUI:C0005747
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 5 alleles in 7 genetic backgrounds
    3 phenotypes from multigenic genotypes
    55 phenotype references
Phenotype Overview

Phenotype Overview
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.
adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice develop hypertension and exhibit elevated blood pressure caused by increased sympathetic tone. Mice homozygous for another knock-out allele exhibit increased methamphetamine-induced ambulatory activity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
  • Blue cells = expressed in wild-type.
    Gray triangles = other expression annotations only
    (e.g. absence of expression or data from mutants).
early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13492 NCBI Gene Model | MGI Sequence Detail 3127 C57BL/6J ± kb
    transcript NM_013503 RefSeq | MGI Sequence Detail 3127 ZRU/MplStud
    polypeptide Q8BLD9 UniProt | EBI | MGI Sequence Detail 478 Not Applicable
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      Genomic 1
      cDNA 13
      Primer pair 4

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-16351, MGD-MRK-16359, MGD-MRK-8895, MGD-MRK-8900
    References
    more
    • Summaries
      All 120
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 20
      Phenotypes 55
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:369865 Li J, et al., Astrocyte D1/D5 Dopamine Receptors Govern Non-Hebbian Long-Term Potentiation at Sensory Synapses onto Lamina I Spinoparabrachial Neurons. J Neurosci. 2024 Aug 7;44(32)
    TSS for Drd5:
    (View these features in JBrowse)
    Transcription Start Site Location Distance from Gene 5'-end
    Tssr1469 Chr5:38477574-38477577 (+) 834 bp
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support. last database update
    10/07/2025
    MGI 6.24 The Jackson Laboratory
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