Drd3 MGI Mouse Gene Detail - MGI:94925 - dopamine receptor D3

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Drd3 Gene Detail
Summary
  • Symbol
    Drd3
  • Name
    dopamine receptor D3
  • Synonyms
    D3R, D3 receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:94925
    NCBI Gene: 13490
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:43574389-43643295 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 16, 28.44 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1492 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_94925
protein coding gene Chr16:43574285-43646353 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022829
protein coding gene Chr16:42468723-42538201 (+)
A/J MGP_AJ_G0022794
protein coding gene Chr16:40548242-40618621 (+)
AKR/J MGP_AKRJ_G0022766
protein coding gene Chr16:41866508-41940034 (+)
BALB/cJ MGP_BALBcJ_G0022795
protein coding gene Chr16:40545417-40611965 (+)
C3H/HeJ MGP_C3HHeJ_G0022559
protein coding gene Chr16:42050987-42121511 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023242
protein coding gene Chr16:43446455-43531297 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020757
protein coding gene Chr16:40626002-40684665 (+)
CAST/EiJ MGP_CASTEiJ_G0022085
protein coding gene Chr16:42257669-42326768 (+)
CBA/J MGP_CBAJ_G0022530
protein coding gene Chr16:45296807-45359066 (+)
DBA/2J MGP_DBA2J_G0022662
protein coding gene Chr16:40281537-40357250 (+)
FVB/NJ MGP_FVBNJ_G0022637
protein coding gene Chr16:40270814-40332108 (+)
LP/J MGP_LPJ_G0022730
protein coding gene Chr16:42180351-42252177 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022656
protein coding gene Chr16:44693209-44768885 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023257
protein coding gene Chr16:41882708-41955212 (+)
PWK/PhJ MGP_PWKPhJ_G0021825
protein coding gene Chr16:40687984-40751644 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021656
protein coding gene Chr16:41786007-41847169 (+)
WSB/EiJ MGP_WSBEiJ_G0022129
protein coding gene Chr16:41983108-42054809 (+)



Homology
more
  • Human Ortholog
    DRD3, dopamine receptor D3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DRD3, dopamine receptor D3
  • Synonyms
    D3DR, ETM1, FET1
  • Links
    NCBI Gene ID: 1814
    UniProt: P35462

  • Chr Location
    3q13.31; chr3:114127580-114199407 (-) GRCh38
Human Diseases
more
  • Diseases
    1 with Drd3 mouse models; 3 with human DRD3 associations

Human Disease Mouse Models
IDs
restless legs syndrome

DOID:0050425
EFO:0004270
ICD10CM:G25.81
ICD9CM:333.94
MESH:D012148
NCI:C84501
OMIM:PS102300
UMLS_CUI:C0035258

 View 1 model
Mouse Models

Human Disease Modeled: restless legs syndrome

Allelic Composition Genetic Background Reference Phenotypes
Drd3tm1Dac/Drd3tm1Dac
B6.129S4-Drd3tm1Dac/J J:96803 View
IDs
essential tremor

DOID:4990
ICD10CM:G25.0
MESH:D020329
NCI:C182453
OMIM:PS190300
ORDO:862
UMLS_CUI:C0270736
IDs
essential tremor 1
IDs
schizophrenia

DOID:5419
DOID:14734
ICD10CM:F20
ICD9CM:295
ICD9CM:295.8
ICD9CM:295.80
ICD9CM:295.9
ICD9CM:295.90
MESH:D012559
NCI:C3362
OMIM:181500
UMLS_CUI:C0036341
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 4 alleles in 9 genetic backgrounds
    24 phenotypes from multigenic genotypes
    112 phenotype references
Phenotype Overview

Phenotype Overview
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.
adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants show exploratory hyperactivity and increased locomotion and rearing behavior, with heterozygous mice displaying similar, but less pronounced, behaviors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
  • Blue cells = expressed in wild-type.
    Gray triangles = other expression annotations only
    (e.g. absence of expression or data from mutants).
early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
    9
  • Literature Summary
    8
  • Comparison Matrix
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022705 Ensembl Gene Model | MGI Sequence Detail 68907 C57BL/6J ± kb
    transcript ENSMUST00000229953 Ensembl | MGI Sequence Detail 1712 Not Applicable
    polypeptide ENSMUSP00000155033 Ensembl | MGI Sequence Detail 478 Not Applicable
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 8
      cDNA 9
      Primer pair 3
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-8898
    References
    more
    • Summaries
      All 177
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 34
      Phenotypes 112
    • Earliest
      J:14384 Copeland NG, et al., A genetic linkage map of the mouse: current applications and future prospects [see comments]. Science. 1993 Oct 1;262(5130):57-66
    • Latest
      J:362500 Enriquez-Traba J, et al., Dissociable control of motivation and reinforcement by distinct ventral striatal dopamine receptors. Nat Neurosci. 2025 Jan;28(1):105-121
    TSS for Drd3:
    (View these features in JBrowse)
    Transcription Start Site Location Distance from Gene 5'-end
    Tssr138528 Chr16:43627760-43627763 (+) 53,373 bp
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support. last database update
    10/07/2025
    MGI 6.24 The Jackson Laboratory
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