Cyp19a1 MGI Mouse Gene Detail - MGI:88587 - cytochrome P450, family 19, subfamily a, polypeptide 1

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Cyp19a1 Gene Detail
Summary
  • Symbol
    Cyp19a1
  • Name
    cytochrome P450, family 19, subfamily a, polypeptide 1
  • Synonyms
    Ar, ArKO, aromatase, Cyp19, Int-5, Int5, p450arom
  • Feature Type
    protein coding gene
  • IDs
    MGI:88587
    NCBI Gene: 13075
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:54073221-54175394 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 9, 29.49 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2286 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88587
protein coding gene Chr9:54073221-54175448 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034821
protein coding gene Chr9:53201811-53232631 (-)
A/J MGP_AJ_G0034802
protein coding gene Chr9:51509769-51537314 (-)
AKR/J MGP_AKRJ_G0034730
protein coding gene Chr9:52662211-52690443 (-)
BALB/cJ MGP_BALBcJ_G0034794
protein coding gene Chr9:51273742-51301208 (-)
C3H/HeJ MGP_C3HHeJ_G0034504
protein coding gene Chr9:53139135-53167406 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035313
protein coding gene Chr9:54703568-54730472 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032225
protein coding gene Chr9:50919952-50948008 (-)
CAST/EiJ MGP_CASTEiJ_G0033826
protein coding gene Chr9:53149349-53178781 (-)
CBA/J MGP_CBAJ_G0034475
protein coding gene Chr9:56575368-56602494 (-)
DBA/2J MGP_DBA2J_G0034634
protein coding gene Chr9:51395386-51422744 (-)
FVB/NJ MGP_FVBNJ_G0034576
protein coding gene Chr9:50591123-50619271 (-)
LP/J MGP_LPJ_G0034716
protein coding gene Chr9:53510227-53537314 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034619
protein coding gene Chr9:58149793-58178348 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035335
protein coding gene Chr9:52667010-52695262 (-)
PWK/PhJ MGP_PWKPhJ_G0033530
protein coding gene Chr9:51368229-51395916 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033365
protein coding gene Chr9:52937297-52966446 (-)
WSB/EiJ MGP_WSBEiJ_G0033938
protein coding gene Chr9:52646209-52674785 (-)



Homology
more
  • Human Ortholog
    CYP19A1, cytochrome P450 family 19 subfamily A member 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYP19A1, cytochrome P450 family 19 subfamily A member 1
  • Synonyms
    ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM
  • Links
    NCBI Gene ID: 1588
    UniProt: P11511

  • Chr Location
    15q21.2; chr15:51208057-51338601 (-) GRCh38
Human Diseases
more
  • Diseases
    2 with Cyp19a1 mouse models; 12 with human CYP19A1 associations

Human Disease Mouse Models
IDs
aromatase excess syndrome
View 1 model
Mouse Models

Human Disease Modeled: aromatase excess syndrome

Allelic Composition Genetic Background Reference Phenotypes
Tg(Cyp19)C2-3Rrte/0
 involves: BALB/c * C57BL/6 J:78693 View
IDs
Sjogren's syndrome

DOID:12894
DOID:416
ICD10CM:M35.0
ICD9CM:710.2
MESH:D012859
NCI:C26883
NCI:C70647
OMIM:270150
UMLS_CUI:C0086981
UMLS_CUI:C1527336

 View 2 models
Mouse Models

Human Disease Modeled: Sjogren's syndrome

Allelic Composition Genetic Background Reference Phenotypes
Cyp19a1tm1Sih/Cyp19a1tm1Sih
involves: 129S/SvEv J:216958 View
Cyp19a1tm1Esi/Cyp19a1tm1Esi
involves: 129S6/SvEvTac * C57BL/6 J:92438 View
IDs
Alzheimer's disease

DOID:10652
ICD10CM:G30
ICD9CM:331.0
KEGG:05010
MESH:D000544
NCI:C2866
UMLS_CUI:C0002395
IDs
bladder neck obstruction

DOID:13948
ICD10CM:N32.0
ICD9CM:596.0
MESH:D001748
NCI:C79541
UMLS_CUI:C0005694
IDs
breast cancer

DOID:1612
DOID:1648
DOID:4241
ICD10CM:C50
ICD9CM:174.8
MESH:D001943
NCI:C9335
OMIM:114480
UMLS_CUI:C0006142
IDs
endometrial cancer

DOID:1380
DOID:5654
EFO:0004230
ICD10CM:C54.1
KEGG:05213
MESH:D016889
NCI:C27815
NCI:C3012
OMIM:608089
UMLS_CUI:C0007103
UMLS_CUI:C0014170
IDs
esophagus adenocarcinoma

DOID:4914
MESH:C562730
NCI:C4025
UMLS_CUI:C0279628
IDs
osteoporosis

DOID:11476
EFO:0003882
ICD10CM:M81.0
ICD9CM:733.0
ICD9CM:733.00
MESH:D010024
NCI:C3298
OMIM:166710
UMLS_CUI:C0029456
IDs
ovarian cancer

DOID:2394
DOID:0060070
DOID:2144
DOID:9595
ICD10CM:C56
ICD9CM:183.0
MESH:D010051
NCI:C4984
NCI:C7431
OMIM:167000
OMIM:607893
ORDO:213500
ORDO:213517
UMLS_CUI:C0919267
UMLS_CUI:C1140680
UMLS_CUI:C1299247
IDs
polycystic ovary syndrome

DOID:11612
EFO:0000660
ICD10CM:E28.2
ICD9CM:256.4
MESH:D011085
NCI:C26862
OMIM:184700
UMLS_CUI:C0032460
IDs
prostate carcinoma in situ

DOID:8634
ICD10CM:D07.5
ICD9CM:233.4
UMLS_CUI:C0154088
IDs
prostatitis

DOID:14654
ICD10CM:N41.9
ICD9CM:601
ICD9CM:601.9
MESH:D011472
NCI:C26866
UMLS_CUI:C0033581
IDs
urethral obstruction

DOID:12577
MESH:D014524
NCI:C79804
UMLS_CUI:C0041972
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    173 phenotypes from 7 alleles in 10 genetic backgrounds
    22 phenotypes from multigenic genotypes
    3 images
    146 phenotype references
Phenotype Overview

Phenotype Overview
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.
adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for various mutations that inactivate the gene exhibit defects affecting fertility including impairments of ovulation, spermiogenesis and mounting behavior.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
  • Blue cells = expressed in wild-type.
    Gray triangles = other expression annotations only
    (e.g. absence of expression or data from mutants).
early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032274 Ensembl Gene Model | MGI Sequence Detail 102174 C57BL/6J ± kb
    transcript ENSMUST00000034811 Ensembl | MGI Sequence Detail 2373 Not Applicable
    polypeptide ENSMUSP00000034811 Ensembl | MGI Sequence Detail 503 Not Applicable
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 6
      cDNA 15
      Primer pair 11
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11424, MGD-MRK-11430, MGD-MRK-2301
    References
    more
    • Summaries
      All 258
      Developmental Gene Expression 34
      Diseases 4
      Gene Ontology 16
      Phenotypes 146
    • Earliest
      J:34987 Naftolin F, et al., The formation of estrogens by central neuroendocrine tissues. Recent Prog Horm Res. 1975;31:295-319
    • Latest
      J:372819 Tian X, et al., Exercise-induced mitochondrial protection in skeletal muscle of ovariectomized mice: A myogenic E(2) synthesis-independent mechanism. Redox Biol. 2025 Jun 21;85:103735
    TSS for Cyp19a1:
    (View these features in JBrowse)
    Transcription Start Site Location Distance from Gene 5'-end
    Tssr89631 Chr9:54157101-54157113 (-) 18,287 bp
    Tssr89630 Chr9:54144543-54144550 (-) 30,847 bp
    Tssr89629 Chr9:54131077-54131080 (-) 44,315 bp
    Tssr89628 Chr9:54125328-54125331 (-) 50,064 bp
    Tssr89627 Chr9:54117224-54117228 (-) 58,168 bp
    Tssr89626 Chr9:54100803-54100807 (-) 74,589 bp
    Tssr89625 Chr9:54090587-54090594 (-) 84,803 bp
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support. last database update
    10/07/2025
    MGI 6.24 The Jackson Laboratory
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