Crp MGI Mouse Gene Detail - MGI:88512 - C-reactive protein, pentraxin-related

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Crp Gene Detail
Summary
  • Symbol
    Crp
  • Name
    C-reactive protein, pentraxin-related
  • Feature Type
    protein coding gene
  • IDs
    MGI:88512
    NCBI Gene: 12944
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:172525623-172527533 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 80.13 cM
  • Mapping Data
    21 experiments
Strain
Comparison
more
  • SNPs within 2kb
    83 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    6
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88512
protein coding gene Chr1:172525622-172660598 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016796
protein coding gene Chr1:178580548-178709171 (+)
A/J MGP_AJ_G0016775
protein coding gene Chr1:171283694-171409695 (+)
AKR/J MGP_AKRJ_G0016741
protein coding gene Chr1:176444800-176587753 (+)
BALB/cJ MGP_BALBcJ_G0016736
protein coding gene Chr1:171812837-171949194 (+)
C3H/HeJ MGP_C3HHeJ_G0016560
protein coding gene Chr1:177021906-177162309 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017198
protein coding gene Chr1:184503508-184648850 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014904
protein coding gene Chr1:162970773-163091722 (+)
CAST/EiJ MGP_CASTEiJ_G0016140
protein coding gene Chr1:176388315-176523062 (+)
CBA/J MGP_CBAJ_G0016534
protein coding gene Chr1:191075957-191230022 (+)
DBA/2J MGP_DBA2J_G0016641
protein coding gene Chr1:170203788-170333747 (+)
FVB/NJ MGP_FVBNJ_G0016638
protein coding gene Chr1:168459799-168578357 (+)
LP/J MGP_LPJ_G0016712
protein coding gene Chr1:179654166-179783126 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016665
protein coding gene Chr1:198291351-198432181 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017234
protein coding gene Chr1:176326480-176484866 (+)
PWK/PhJ MGP_PWKPhJ_G0015926
protein coding gene Chr1:169588699-169720531 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015708
protein coding gene Chr1:175286523-175423466 (+)
WSB/EiJ MGP_WSBEiJ_G0016202
protein coding gene Chr1:176479767-176608749 (+)



Homology
more
  • Human Ortholog
    CRP, C-reactive protein
  • Vertebrate Orthologs
    8
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CRP, C-reactive protein
  • Synonyms
    PTX1
  • Links
    NCBI Gene ID: 1401
    UniProt: P02741

  • Chr Location
    1q23.2; chr1:159712289-159714589 (-) GRCh38
Human Diseases
more
  • Diseases
    17 with human CRP associations

Human Disease Mouse Models
IDs
acute kidney failure
IDs
antiphospholipid syndrome

DOID:2988
ICD10CM:D68.61
MESH:D016736
NCI:C61283
OMIM:107320
UMLS_CUI:C0085278
IDs
arthritis

DOID:848
ICD10CM:M19.90
MESH:D001168
NCI:C2883
UMLS_CUI:C0003864
IDs
heart disease

DOID:114
ICD10CM:I51.9
ICD9CM:429.9
MESH:D006331
NCI:C3079
UMLS_CUI:C0018799
IDs
human immunodeficiency virus infectious disease

DOID:526
ICD10CM:B20
ICD9CM:042
ICD9CM:042-042.99
MESH:D015658
NCI:C3108
UMLS_CUI:C0019693
IDs
hypertension

DOID:10763
EFO:0000537
ICD10CM:I10
ICD9CM:401-405.99
ICD9CM:997.91
MESH:D006973
NCI:C3117
UMLS_CUI:C0020538
IDs
inflammatory bowel disease
IDs
interstitial nephritis

DOID:1063
ICD10CM:N12
MESH:D009395
NCI:C26834
UMLS_CUI:C0027707
IDs
Kawasaki disease

DOID:13378
EFO:0004246
ICD10CM:M30.3
ICD9CM_2006:446.1
ICD9CM:446.1
MESH:D009080
NCI:C34825
OMIM:611775
UMLS_CUI:C0026691
IDs
Kuhnt-Junius degeneration

DOID:10873
ICD10CM:H35.32
ICD9CM_2006:362.52
ICD9CM:362.52
UMLS_CUI:C0271084
IDs
lupus nephritis
IDs
lymphopenia

DOID:614
ICD10CM:D72.810
ICD9CM:288.51
MESH:D008231
UMLS_CUI:C0024312
IDs
macular degeneration
IDs
middle cerebral artery infarction

DOID:3525
MESH:D020244
UMLS_CUI:C0740392
IDs
obstructive sleep apnea

DOID:0050848
ICD10CM:G47.33
ICD9CM:327.23
ICD9CM:780.57
MESH:D020181
NCI:C116337
OMIM:107650
UMLS_CUI:C0520679
IDs
renal fibrosis
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

Phenotype Overview
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.
adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele lack detectable C-reactive protein in the serum but are otherwise healthy and fertile. Mice homozgyous for another null allele exhibit increased acetaminophen-induced liver injury and lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
  • Blue cells = expressed in wild-type.
    Gray triangles = other expression annotations only
    (e.g. absence of expression or data from mutants).
early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
    3
  • cDNA Data
  • Literature Summary
    5
  • Comparison Matrix
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12944 NCBI Gene Model | MGI Sequence Detail 1911 C57BL/6J ± kb
    transcript NM_007768 RefSeq | MGI Sequence Detail 1698 Not Specified
    polypeptide P14847 UniProt | EBI | MGI Sequence Detail 225 Not Applicable
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 60
      Genomic 21
      cDNA 34
      Primer pair 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-2156, MGI:2138184
    References
    more
    • Summaries
      All 95
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 11
    • Earliest
      J:129706 Ciliberto G, et al., Inducible and tissue-specific expression of human C-reactive protein in transgenic mice. EMBO J. 1987 Dec 20;6(13):4017-22
    • Latest
      J:341215 Fu Y, et al., C-reactive protein deficiency ameliorates experimental abdominal aortic aneurysms. Front Immunol. 2023;14:1233807
    TSS for Crp:
    (View these features in JBrowse)
    Transcription Start Site Location Distance from Gene 5'-end
    Tssr10246 Chr1:172525613-172525630 (+) -1 bp
    Tssr10247 Chr1:172526556-172526578 (+) 944 bp
    Tssr10248 Chr1:172526622-172526633 (+) 1,005 bp
    Tssr10249 Chr1:172526646-172526661 (+) 1,031 bp
    Tssr10250 Chr1:172526701-172526713 (+) 1,084 bp
    Tssr10251 Chr1:172526757-172526767 (+) 1,139 bp
    Tssr10252 Chr1:172526823-172526828 (+) 1,203 bp
    Tssr10253 Chr1:172526872-172526883 (+) 1,255 bp
    Tssr10254 Chr1:172526937-172526946 (+) 1,319 bp
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support. last database update
    10/07/2025
    MGI 6.24 The Jackson Laboratory
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