Ar MGI Mouse Gene Detail - MGI:88064 - androgen receptor

Using the Quick Search Tool for more information.', STICKY, CAPTION, 'Quick Search Tips', CENTER, BELOW, WIDTH, 450, DELAY, 600, CLOSECLICK, CLOSETEXT, 'Close X');" onMouseOut="nd();">
[フレーム]
Ar Gene Detail
Summary
  • Symbol
    Ar
  • Name
    androgen receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:88064
    NCBI Gene: 11835
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:97192375-97366821 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome X, 42.82 cM
  • Mapping Data
    33 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2753 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88064
protein coding gene ChrX:97192363-97366824 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035931
protein coding gene ChrX:94519451-94700407 (+)
A/J MGP_AJ_G0035916
protein coding gene ChrX:94631610-94809631 (+)
AKR/J MGP_AKRJ_G0035832
protein coding gene ChrX:97292110-97471900 (+)
BALB/cJ MGP_BALBcJ_G0035899
protein coding gene ChrX:93407432-93578928 (+)
C3H/HeJ MGP_C3HHeJ_G0035608
protein coding gene ChrX:94992285-95167427 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036428
protein coding gene ChrX:97458294-97643128 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033258
protein coding gene ChrX:92480947-92650344 (+)
CAST/EiJ MGP_CASTEiJ_G0034895
protein coding gene ChrX:79328711-79503668 (+)
CBA/J MGP_CBAJ_G0035583
protein coding gene ChrX:100460337-100628022 (+)
DBA/2J MGP_DBA2J_G0035737
protein coding gene ChrX:93888415-94059222 (+)
FVB/NJ MGP_FVBNJ_G0035675
protein coding gene ChrX:93271509-93443758 (+)
LP/J MGP_LPJ_G0035827
protein coding gene ChrX:95537760-95715093 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035710
protein coding gene ChrX:104895192-105106596 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036455
protein coding gene ChrX:94291304-94467544 (+)
PWK/PhJ MGP_PWKPhJ_G0034594
protein coding gene ChrX:77021615-77190976 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034422
protein coding gene ChrX:80192320-80361924 (+)
WSB/EiJ MGP_WSBEiJ_G0035034
protein coding gene ChrX:92998626-93174570 (+)



Homology
more
  • Human Ortholog
    AR, androgen receptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AR, androgen receptor
  • Synonyms
    AIS, AR8, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM
  • Links
    NCBI Gene ID: 367
    UniProt: P10275

  • Chr Location
    Xq12; chrX:67544021-67730619 (+) GRCh38
  • MGI Vertebrate Homology
    Ar stringent orthology
    1 human;1 mouse;1 rat;1 zebrafish
  • HCOP
    vertebrate homology predictions: AR
  • Gene Tree
    Ar
Human Diseases
more
  • Diseases
    3 with Ar mouse models; 14 with human AR associations

Human Disease Mouse Models
IDs
androgen insensitivity syndrome

DOID:4674
DOID:4672
ICD10CM:E34.5
ICD9CM:259.5
ICD9CM:259.51
MESH:D013734
NCI:C27226
OMIM:300068
ORDO:754
UMLS_CUI:C0039585

 View 8 models
Mouse Models

Human Disease Modeled: androgen insensitivity syndrome

Allelic Composition Genetic Background Reference Phenotypes
Artm1.1Verh/Y
 involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 J:88169 View
ArTfm/Y
Tg(TSPY)9Jshm/0
 involves: NMRI * STOCK EdaTa Atp7aMo-blo J:140803 View
Artm1.1Jdz/Y
 B6.129X1-Artm1.1Jdz J:123057 View
Artm1Ska/Y
Tg(CMV-cre)1Ipc/?
 involves: C57BL/6 * CBA J:85484 View
Artm1.1Jdz/Y
 involves: 129X1/SvJ * C57BL/6 J:122327 View
ArTfm/Y
 involves: NMRI * STOCK EdaTa Atp7aMo-blo J:140803 View
ArTfm/Y
 involves: STOCK EdaTa Atp7aMo-blo J:140803 View
ArTfm/Y
 STOCK EdaTa Atp7aMo-blo/+ + J:5173 View

NOT Models
No similarity to the expected human disease phenotype was found.

Allelic Composition Genetic Background Reference Phenotypes
Artm4(AR)Dmr/Y
 involves: 129S1/Sv * C57BL/6J J:104360 View
IDs
obesity

DOID:9970
EFO:0001073
ICD10CM:E66.9
ICD9CM:278.00
MESH:D009765
NCI:C159658
OMIM:601665
UMLS_CUI:C0028754

 View 1 model
Mouse Models

Human Disease Modeled: obesity

Allelic Composition Genetic Background Reference Phenotypes
Artm1Ska/Y
Tg(CMV-cre)1Ipc/?
 involves: C57BL/6 * CBA J:85484 View
IDs
type 2 diabetes mellitus
View 1 model
Mouse Models

Human Disease Modeled: type 2 diabetes mellitus

Allelic Composition Genetic Background Reference Phenotypes
Artm1Verh/Y
Tg(Fabp4-cre)1Rev/0
 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 J:196857 View
IDs
alcohol dependence
IDs
attention deficit hyperactivity disorder
IDs
conduct disorder

DOID:12995
EFO:0004216
ICD10CM:F91
ICD9CM:312.9
MESH:D019955
NCI:C89329
UMLS_CUI:C0149654
IDs
cryptorchidism

DOID:11383
ICD10CM:Q53.9
ICD9CM_2006:752.51
ICD9CM:752.51
MESH:D003456
NCI:C12326
OMIM:219050
UMLS_CUI:C0010417

 View 1 model
Mouse Models

Human Disease Modeled: cryptorchidism

Allelic Composition Genetic Background Reference Phenotypes
ArTfm/Y
Insl3tm1Imad/Insl3tm1Imad
involves: 129/Sv * CD-1 * STOCK EdaTa J:83429 View
IDs
endometrial cancer

DOID:1380
DOID:5654
EFO:0004230
ICD10CM:C54.1
KEGG:05213
MESH:D016889
NCI:C27815
NCI:C3012
OMIM:608089
UMLS_CUI:C0007103
UMLS_CUI:C0014170
IDs
IDs
Kennedy's disease
View 1 model
Mouse Models

Human Disease Modeled: Kennedy's disease

Allelic Composition Genetic Background Reference Phenotypes
Artm4(AR)Dmr/Y
 involves: 129S1/Sv * C57BL/6J J:104360 J:114552 View
IDs
leiomyoma

DOID:127
MESH:D007889
NCI:C3157
UMLS_CUI:C0023267
IDs
oppositional defiant disorder
IDs
partial androgen insensitivity syndrome
IDs
 View 4 models
Mouse Models

Human Disease Modeled: prostate cancer

Allelic Composition Genetic Background Reference Phenotypes
Artm1(AR)Dmr/Y
Tg(TRAMP)8247Ng/0
 involves: 129S1/Sv * C57BL/6 J:108849 View
Artm2(AR)Dmr/Y
Tg(TRAMP)8247Ng/0
 involves: 129S1/Sv * C57BL/6 J:108849 View
Artm3(AR)Dmr/Y
Tg(TRAMP)8247Ng/0
 involves: 129S1/Sv * C57BL/6 J:108849 View
Artm1Verh/Y
Ptentm1Hwu/Ptentm1Hwu
Tg(Pbsn-cre)4Prb/0
 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * DBA/2 J:172730 View
IDs
spinal muscular atrophy

DOID:12377
ICD10CM:G12.9
ICD9CM:335.1
ICD9CM:335.10
MESH:D009134
NCI:C85075
UMLS_CUI:C0026847
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    9 with disease annotations
  • References
    12 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    170 phenotypes from 16 alleles in 35 genetic backgrounds
    84 phenotypes from multigenic genotypes
    4 images
    379 phenotype references
Phenotype Overview

Phenotype Overview
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.
adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Hemizygous mutant males are androgen-resistant and therefore have small, undescended testes, and lack epididymal structures, vas deferens, and male accessory glands. They resemble females physically and behaviorally, but lack female reproductive organs.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
  • Blue cells = expressed in wild-type.
    Gray triangles = other expression annotations only
    (e.g. absence of expression or data from mutants).
early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000046532 Ensembl Gene Model | MGI Sequence Detail 174447 C57BL/6J ± kb
    transcript ENSMUST00000052837 Ensembl | MGI Sequence Detail 10048 Not Applicable
    polypeptide ENSMUSP00000052648 Ensembl | MGI Sequence Detail 899 Not Applicable
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 66
      Genomic 14
      cDNA 32
      Primer pair 15
      Other 5

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-1384, MGD-MRK-15046, MGI:2148007
    References
    more
    • Summaries
      All 677
      Developmental Gene Expression 103
      Diseases 12
      Gene Ontology 47
      Phenotypes 379
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
    • Latest
      J:373472 Xie Y, et al., Testosterone Delays Bone Microstructural Destruction via Osteoblast-Androgen Receptor-Mediated Upregulation of Tenascin-C. Adv Sci (Weinh). 2025 Aug;12(31):e01518
    TSS for Ar:
    (View these features in JBrowse)
    Transcription Start Site Location Distance from Gene 5'-end
    Tssr161585 ChrX:97192325-97192388 (+) -18 bp
    Tssr161586 ChrX:97193272-97193320 (+) 921 bp
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support. last database update
    10/07/2025
    MGI 6.24 The Jackson Laboratory
    This site uses cookies. Some cookies are essential for site operations and others help us analyze use and utility of our web site. Please refer to our privacy policy for more information.
    Close Save preferences

    AltStyle によって変換されたページ (->オリジナル) /