Agt MGI Mouse Gene Detail - MGI:87963 - angiotensinogen

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Agt Gene Detail

Summary

Symbol

Agt
Name

angiotensinogen
Synonyms

angiotensin precursor, Aogen, Serpina8

Feature Type

protein coding gene
IDs

MGI:87963
NCBI Gene: 11606
Alliance

gene page
Transcription Start Sites

13 TSS

Location &
Maps

Sequence Map

Chr8:125283326-125296445 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 72.81 cM
Mapping Data

19 experiments

Strain
Comparison

SNPs within 2kb

498 from dbSNP Build 142
Strain Annotations

18
RFLP

7

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_87963	protein coding gene	Chr8:125283273-125296445 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0034272	protein coding gene	Chr8:128245438-128260823 (-)
A/J	MGP_AJ_G0034252	protein coding gene	Chr8:122939198-122952182 (-)
AKR/J	MGP_AKRJ_G0034179	protein coding gene	Chr8:126469592-126488387 (-)
BALB/cJ	MGP_BALBcJ_G0034245	protein coding gene	Chr8:123124486-123138317 (-)
C3H/HeJ	MGP_C3HHeJ_G0033956	protein coding gene	Chr8:127120070-127136555 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0034765	protein coding gene	Chr8:132535664-132548855 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031706	protein coding gene	Chr8:115708688-115721570 (-)
CAST/EiJ	MGP_CASTEiJ_G0033283	protein coding gene	Chr8:127236714-127250973 (-)
CBA/J	MGP_CBAJ_G0033929	protein coding gene	Chr8:137396367-137412818 (-)
DBA/2J	MGP_DBA2J_G0034085	protein coding gene	Chr8:122096196-122109344 (-)
FVB/NJ	MGP_FVBNJ_G0034029	protein coding gene	Chr8:121267798-121281960 (-)
LP/J	MGP_LPJ_G0034174	protein coding gene	Chr8:128401374-128414393 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034076	protein coding gene	Chr8:139479234-139492297 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034784	protein coding gene	Chr8:126710217-126723243 (-)
PWK/PhJ	MGP_PWKPhJ_G0032985	protein coding gene	Chr8:121860106-121873269 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0032824	protein coding gene	Chr8:125350926-125366646 (-)
WSB/EiJ	MGP_WSBEiJ_G0033400	protein coding gene	Chr8:127431587-127444652 (-)

Homology

Human Ortholog

AGT, angiotensinogen

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AGT, angiotensinogen
Synonyms

ANHU, hFLT1, SERPINA8
Links

HGNC:333

NCBI Gene ID: 183

UniProt: P01019
Chr Location

1q42.2; chr1:230690776-230745583 (-) GRCh38

MGI Vertebrate Homology

Agt stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: AGT
Gene Tree

Agt

Human Diseases

Diseases

21 with human AGT associations

Human Disease	Mouse Models
allergic disease IDs allergic disease DOID:1205 ICD10CM:T78.40 MESH:D006967 NCI:C3114 UMLS_CUI:C0020517
atrial fibrillation IDs atrial fibrillation DOID:0060224 ICD9CM:427.31 MESH:D001281 NCI:C50466 UMLS_CUI:C0004238
breast cancer IDs breast cancer DOID:1612 DOID:1648 DOID:4241 ICD10CM:C50 ICD9CM:174.8 MESH:D001943 NCI:C9335 OMIM:114480 UMLS_CUI:C0006142
carotid artery disease IDs carotid artery disease DOID:3407 MESH:D002340 NCI:C84476 UMLS_CUI:C0007273
cerebrovascular disease IDs cerebrovascular disease DOID:6713 DOID:12214 DOID:3455 DOID:8231 EFO:0000712 ICD10CM:I67.9 ICD9CM:430-438.99 ICD9CM:437.9 MESH:D002561 NCI:C2938 UMLS_CUI:C0007820
congestive heart failure IDs congestive heart failure DOID:6000 DOID:395 ICD10CM:I50 ICD10CM:I50.9 ICD9CM:428 ICD9CM:428.0 ICD9CM:428.9 MESH:D006333 NCI:C3080 NCI:C50577 UMLS_CUI:C0018801 UMLS_CUI:C0018802
diabetic retinopathy IDs diabetic retinopathy DOID:8947 ICD9CM:362.0 MESH:D003930 NCI:C34538 UMLS_CUI:C0011884
Fabry disease IDs Fabry disease DOID:14499 ICD10CM:E75.21 MESH:D000795 NCI:C84701 OMIM:301500 UMLS_CUI:C0002986
hydronephrosis IDs hydronephrosis DOID:11111 ICD10CM:N13.30 ICD9CM:591 MESH:D006869 NCI:C26796 UMLS_CUI:C0020295
hyperinsulinism IDs hyperinsulinism DOID:2018 ICD10CM:E16.1 MESH:D006946 UMLS_CUI:C0020459
hypertension IDs hypertension DOID:10763 EFO:0000537 ICD10CM:I10 ICD9CM:401-405.99 ICD9CM:997.91 MESH:D006973 NCI:C3117 UMLS_CUI:C0020538
hypertrophic cardiomyopathy IDs hypertrophic cardiomyopathy DOID:11984 DOID:11986 ICD9CM:425.1 ICD9CM:425.11 KEGG:05410 MESH:D002312 NCI:C34449 ORDO:217569 UMLS_CUI:C0007194
IgA vasculitis IDs IgA vasculitis DOID:11123 ICD10CM:D69.0 ICD9CM_2006:287.0 ICD9CM:287.0 MESH:D011695 NCI:C34963 ORDO:761 UMLS_CUI:C0034152
inflammatory bowel disease IDs inflammatory bowel disease DOID:0050589 EFO:0003767 KEGG:05321 MESH:D015212 NCI:C3138 OMIM:PS266600 UMLS_CUI:C0021390
mitral valve prolapse IDs mitral valve prolapse DOID:988 MESH:D008945 NCI:C50655 OMIM:157700 OMIM:607829 OMIM:610840 UMLS_CUI:C0026267
myocardial infarction IDs myocardial infarction DOID:5844 EFO:0000612 ICD10CM:I21 MESH:D009203 NCI:C27996 OMIM:608557 UMLS_CUI:C0027051
obesity IDs obesity DOID:9970 EFO:0001073 ICD10CM:E66.9 ICD9CM:278.00 MESH:D009765 NCI:C159658 OMIM:601665 UMLS_CUI:C0028754
otosclerosis IDs otosclerosis DOID:12185 EFO:0004213 ICD10CM:H80.80 ICD9CM:387.8 OMIM:PS166800 ORDO:2794 UMLS_CUI:C0029696
pre-eclampsia IDs pre-eclampsia DOID:10591 DOID:12684 ICD10CM:O14 MESH:D011225 NCI:C85021 OMIM:189800 OMIM:609402 OMIM:609403 OMIM:609404 OMIM:614592 ORDO:275555 UMLS_CUI:C0032914
pulmonary edema IDs pulmonary edema DOID:11396 DOID:13472 ICD10CM:J81 MESH:D011654 NCI:C26868 UMLS_CUI:C0034063
sick sinus syndrome IDs sick sinus syndrome DOID:13884 ICD10CM:I49.5 MESH:D012804 NCI:C62244 OMIM:163800 OMIM:608567 ORDO:166282 UMLS_CUI:C0037052

Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes

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Phenotype Summary

66 phenotypes from 4 alleles in 5 genetic backgrounds
7 phenotypes from multigenic genotypes
1 images
78 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Endonuclease-mediated

7
Targeted

9
Genomic Mutations

1 involving Agt
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

34 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mutation of this gene results in small body size and lower body fat, decreased blood pressure and hypotension, kidney abnormalities, polydipsia and polyuria.

Gene Ontology
(GO)
Classifications

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All GO Annotations

166
GO References

37

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

Expression

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

848
Tissues

80
cDNA Data

144
Literature Summary

26

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA AGT

Xenbase agt

ZFIN agt

Sequences &
Gene Models

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All Sequences

44
RefSeq

4
UniProt

4
CCDS

CCDS40513.2

Ensembl

ENSMUSG00000031980 (Evidence)
NCBI Gene

11606

			Length	Strain/Species	Flank
genomic	11606	NCBI Gene Model \| MGI Sequence Detail	13120	C57BL/6J	± kb
transcript	NM_001416312	RefSeq \| MGI Sequence Detail	1900	ZRU/MplStud
polypeptide	P11859	UniProt \| EBI \| MGI Sequence Detail	477	Not Applicable

Protein
Information

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UniProt

4 Sequences
Protein Ontology

PR:000003847 angiotensinogen

(term hierarchy)
InterPro Domains

IPR000227 Angiotensinogen

IPR033834 Angiotensinogen, serpin domain

IPR023796 Serpin domain

IPR000215 Serpin family

IPR036186 Serpin superfamily

IPR042178 Serpin superfamily, domain 1

IPR042185 Serpin superfamily, domain 2
GlyGen

P11859 4 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

Molecular
Reagents

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All nucleic 161

Genomic 10

cDNA 146

Primer pair 4

Other 1

Microarray probesets 3

Other
Accession IDs

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MGD-MRK-1192, MGI:2142488

References

Summaries

All 268

Developmental Gene Expression 26

Gene Ontology 37

Phenotypes 78
Earliest

J:9259 Clouston WM, et al., Molecular cloning of the mouse angiotensinogen gene. Genomics. 1988 Apr;2(3):240-8
Latest

J:363294 Wang S, et al., SOX4 facilitates brown fat development and maintenance through EBF2-mediated thermogenic gene program in mice. Cell Death Differ. 2025 Mar;32(3):447-465

TSS for Agt:

(View these features in JBrowse)

Transcription Start Site Location Distance from Gene 5'-end

Tssr83450 Chr8:125296584-125296606 (-) -150 bp

Tssr83449 Chr8:125296435-125296453 (-) 1 bp

Tssr83448 Chr8:125295608-125295612 (-) 835 bp

Tssr83447 Chr8:125291187-125291221 (-) 5,241 bp

Tssr83446 Chr8:125291085-125291100 (-) 5,352 bp

Tssr83445 Chr8:125290919-125290932 (-) 5,519 bp

Tssr83444 Chr8:125290680-125290694 (-) 5,758 bp

Tssr83443 Chr8:125290669-125290677 (-) 5,772 bp

Tssr83442 Chr8:125290610-125290644 (-) 5,818 bp

Tssr83441 Chr8:125290505-125290516 (-) 5,934 bp

Tssr2731 Chr8:125289565-125289571 (-) 6,877 bp

Tssr83440 Chr8:125286058-125286068 (-) 10,382 bp

Tssr83439 Chr8:125286047-125286056 (-) 10,393 bp

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)

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Send questions and comments to User Support. last database update
10/07/2025
MGI 6.24 The Jackson Laboratory