P2ry14 MGI Mouse Gene Detail - MGI:2155705 - purinergic receptor P2Y, G-protein coupled, 14

Summary

• Symbol
  P2ry14
• Name
  purinergic receptor P2Y, G-protein coupled, 14
• Synonyms
  A330108O13Rik, Gpr105, P2Y14

• Feature Type
  protein coding gene
• IDs
  MGI:2155705
  NCBI Gene: 140795
• Alliance
  gene page
• Transcription Start Sites
  18 TSS

Location &
Maps

• Sequence Map
  Chr3:59022044-59060913 bp, - strand

  From NCBI annotation of GRCm39
  
• View this region in JBrowse
  
• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 3, 28.96 cM
• Mapping Data
  3 experiments

Strain
Comparison

• SNPs within 2kb
  1199 from dbSNP Build 142
• Strain Annotations
  18

Homology

• Human Ortholog
  P2RY14, purinergic receptor P2Y14

• Vertebrate Orthologs
  2

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  18 phenotypes from 3 alleles in 3 genetic backgrounds
  24 phenotype references
  

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

• All Mutations and Alleles
  14
• Endonuclease-mediated
  8
• Radiation induced
  1
• Targeted
  5
• Genomic Mutations
  1 involving P2ry14
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  34 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Mice homozygous for a null allele fail to exhibit increased glucose mediated forestomach muscle tension. Mice homozygous for a different null allele show decreased gastrointestinal emptying, impaired glucose tolerance, decreased glucose-stimulated insulin release, and reduced airway responsiveness.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  15
• GO References
  7

Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

• Blue cells = expressed in wild-type.
  Gray triangles = other expression annotations only
  (e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

• Assay Results
  706
• cDNA Data
  15

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase p2ry14

Sequences &
Gene Models

• All Sequences
  70
• RefSeq
  16
• UniProt
  5
• CCDS
  CCDS17371.1, CCDS79913.1

• Ensembl
  ENSMUSG00000036381 (Evidence)
• NCBI Gene
  140795

Representative Sequences				Length	Strain/Species	Flank
	genomic	140795	NCBI Gene Model | MGI Sequence Detail	38870	C57BL/6J	± kb
	transcript	NM_001287123	RefSeq | MGI Sequence Detail	1994	ZRU/MplStud
	polypeptide	Q9ESG6	UniProt | EBI | MGI Sequence Detail	338	Not Applicable

For the selected sequence download in FASTA format forward to NCBI BLAST

Protein
Information

• UniProt
  5 Sequences
• Protein Ontology
  PR:000001571 P2Y purinoceptor 14
  (term hierarchy)
• InterPro Domains
  IPR017452 GPCR, rhodopsin-like, 7TM
  IPR000276 G protein-coupled receptor, rhodopsin-like
  IPR005466 P2Y14 purinoceptor
• GlyGen
  Q9ESG6 2 sites

Molecular
Reagents

• All nucleic 15

  cDNA 15

  
  

  Microarray probesets 3

Other
Accession IDs

References

• Summaries
  All 57

  Diseases 1

  Gene Ontology 7

  Phenotypes 24
• Earliest
  J:113918 Chambers JK, et al., A G protein-coupled receptor for UDP-glucose. J Biol Chem. 2000 Apr 14;275(15):10767-71
• Latest
  J:357394 Patritti-Cram J, et al., NF1-dependent disruption of the blood-nerve-barrier is improved by blockade of P2RY14. iScience. 2024 Jul 19;27(7):110294

TSS for P2ry14:

(View these features in JBrowse)