Pik3cb MGI Mouse Gene Detail - MGI:1922019 - phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta

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Pik3cb Gene Detail
Summary
  • Symbol
    Pik3cb
  • Name
    phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
  • Synonyms
    1110001J02Rik, p110beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922019
    NCBI Gene: 74769
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:98920455-99022264 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 9, 51.41 cM, cytoband E4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2907 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922019
protein coding gene Chr9:98918707-99022674 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035165
protein coding gene Chr9:100379512-100497197 (-)
A/J MGP_AJ_G0035146
protein coding gene Chr9:96842070-96949092 (-)
AKR/J MGP_AKRJ_G0035078
protein coding gene Chr9:99208872-99317857 (-)
BALB/cJ MGP_BALBcJ_G0035139
protein coding gene Chr9:96526977-96632035 (-)
C3H/HeJ MGP_C3HHeJ_G0034849
protein coding gene Chr9:99603587-99714344 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035659
protein coding gene Chr9:103261256-103383329 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032558
protein coding gene Chr9:94589586-94695767 (-)
CAST/EiJ MGP_CASTEiJ_G0034160
protein coding gene Chr9:99410916-99522160 (-)
CBA/J MGP_CBAJ_G0034817
protein coding gene Chr9:106802688-106920839 (-)
DBA/2J MGP_DBA2J_G0034979
protein coding gene Chr9:96355879-96461418 (-)
FVB/NJ MGP_FVBNJ_G0034927
protein coding gene Chr9:95179236-95284796 (-)
LP/J MGP_LPJ_G0035055
protein coding gene Chr9:100629788-100742409 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034966
protein coding gene Chr9:108731130-108848752 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035681
protein coding gene Chr9:99421938-99534322 (-)
PWK/PhJ MGP_PWKPhJ_G0033867
protein coding gene Chr9:96563201-96676137 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033702
protein coding gene Chr9:99508858-99624161 (-)
WSB/EiJ MGP_WSBEiJ_G0034280
protein coding gene Chr9:99322980-99433494 (-)



Homology
more
  • Human Ortholog
    PIK3CB, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PIK3CB, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
  • Synonyms
    P110BETA, PI3K, PI3KBETA, PIK3C1
  • Links
    NCBI Gene ID: 5291
    UniProt: P42338

  • Chr Location
    3q22.3; chr3:138652336-138834928 (-) GRCh38
Human Diseases
more
  • Diseases
    3 with human PIK3CB associations

Human Disease Mouse Models
IDs
glioblastoma

DOID:3068
DOID:3075
DOID:3080
MESH:D005909
NCI:C129295
NCI:C39750
NCI:C9094
UMLS_CUI:C0017636
UMLS_CUI:C0278878
UMLS_CUI:C1514422
IDs
prostate adenocarcinoma

DOID:2526
NCI:C2919
UMLS_CUI:C0007112
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    51 phenotypes from 9 alleles in 13 genetic backgrounds
    9 phenotypes from multigenic genotypes
    1 images
    70 phenotype references
Phenotype Overview

Phenotype Overview
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.
adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit 30% fetal lethality, decreased size at birth and postnatally, abnormal glucose homeostasis, and dyslipidemia. Mice homozygous for a different knock-out allele die prior to E8.5
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
  • Blue cells = expressed in wild-type.
    Gray triangles = other expression annotations only
    (e.g. absence of expression or data from mutants).
early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74769 NCBI Gene Model | MGI Sequence Detail 101810 C57BL/6J ± kb
    transcript NM_029094 RefSeq | MGI Sequence Detail 4854 C57BL/6
    polypeptide Q8BTI9 UniProt | EBI | MGI Sequence Detail 1064 Not Applicable
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000012720 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
    • PDB
    • EC
    • InterPro Domains
      IPR016024 Armadillo-type fold
      IPR035892 C2 domain superfamily
      IPR002420 C2 phosphatidylinositol 3-kinase-type domain
      IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
      IPR036940 Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
      IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
      IPR003113 Phosphatidylinositol 3-kinase, adaptor-binding domain
      IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
      IPR015433 Phosphatidylinositol kinase
      IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
      IPR042236 Phosphoinositide 3-kinase, accessory (PIK) domain superfamily
      IPR037702 PI3Kbeta, catalytic domain
      IPR011009 Protein kinase-like domain superfamily
      IPR029071 Ubiquitin-like domain superfamily
    • GlyGen
      Q8BTI9 2 sites, 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 47
      cDNA 44
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2143049
    References
    more
    • Summaries
      All 152
      Developmental Gene Expression 13
      Gene Ontology 19
      Phenotypes 70
    • Earliest
      J:214 ALLEN SL, H-2f, a tenth allele at the histocompatibility-2 locus in the mouse as determined by tumor transplantation. Cancer Res. 1955 Jun;15(5):315-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    TSS for Pik3cb:
    (View these features in JBrowse)
    Transcription Start Site Location Distance from Gene 5'-end
    Tssr91044 Chr9:99022200-99022279 (-) 24 bp
    Tssr91043 Chr9:99022163-99022177 (-) 94 bp
    Tssr91042 Chr9:99022118-99022133 (-) 138 bp
    Tssr91041 Chr9:99018156-99018159 (-) 4,106 bp
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support. last database update
    10/07/2025
    MGI 6.24 The Jackson Laboratory
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