Ebag9 MGI Mouse Gene Detail - MGI:1859920 - estrogen receptor-binding fragment-associated gene 9

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Ebag9 Gene Detail
Summary
  • Symbol
    Ebag9
  • Name
    estrogen receptor-binding fragment-associated gene 9
  • Synonyms
    Rcas1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859920
    NCBI Gene: 55960
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:44482571-44504911 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 15, 16.91 cM, cytoband D1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    566 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859920
protein coding gene Chr15:44482571-44504916 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021832
protein coding gene Chr15:43240640-43262550 (+)
A/J MGP_AJ_G0021792
protein coding gene Chr15:41596809-41618747 (+)
AKR/J MGP_AKRJ_G0021773
protein coding gene Chr15:42826052-42846821 (+)
BALB/cJ MGP_BALBcJ_G0021799
protein coding gene Chr15:41673728-41694884 (+)
C3H/HeJ MGP_C3HHeJ_G0021573
protein coding gene Chr15:42746844-42767520 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022238
protein coding gene Chr15:44922876-44948381 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019775
protein coding gene Chr15:39125105-39148096 (+)
CAST/EiJ MGP_CASTEiJ_G0021090
protein coding gene Chr15:43264856-43291449 (+)
CBA/J MGP_CBAJ_G0021542
protein coding gene Chr15:46471956-46494345 (+)
DBA/2J MGP_DBA2J_G0021666
protein coding gene Chr15:41400130-41421535 (+)
FVB/NJ MGP_FVBNJ_G0021644
protein coding gene Chr15:40702852-40723961 (+)
LP/J MGP_LPJ_G0021736
protein coding gene Chr15:43008625-43031900 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021668
protein coding gene Chr15:49882131-49909297 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022261
protein coding gene Chr15:43007519-43030096 (+)
PWK/PhJ MGP_PWKPhJ_G0020835
protein coding gene Chr15:41454933-41476742 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020672
protein coding gene Chr15:42691285-42717259 (+)
WSB/EiJ MGP_WSBEiJ_G0021145
protein coding gene Chr15:42907087-42928549 (+)



Homology
more
  • Human Ortholog
    EBAG9, estrogen receptor binding site associated antigen 9
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EBAG9, estrogen receptor binding site associated antigen 9
  • Synonyms
    EB9, PDAF
  • Links
    NCBI Gene ID: 9166
    UniProt: O00559

  • Chr Location
    8q23.2; chr8:109539702-109570072 (+) GRCh38
Human Diseases
more
  • Diseases
    1 with human EBAG9 associations

Human Disease Mouse Models
IDs
breast cancer

DOID:1612
DOID:1648
DOID:4241
ICD10CM:C50
ICD9CM:174.8
MESH:D001943
NCI:C9335
OMIM:114480
UMLS_CUI:C0006142
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    1 images
    17 phenotype references
Phenotype Overview

Phenotype Overview
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.
adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    3
  • Gene trapped
    5
  • Targeted
    5
  • Genomic Mutations
    2 involving Ebag9
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Homozygous null mice have decreased susceptibility to bacterial infections and have CD8+ T cells with enhanced cytolytic activity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
  • Blue cells = expressed in wild-type.
    Gray triangles = other expression annotations only
    (e.g. absence of expression or data from mutants).
early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
    8
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022339 Ensembl Gene Model | MGI Sequence Detail 22341 C57BL/6J ± kb
transcript ENSMUST00000022964 Ensembl | MGI Sequence Detail 1613 Not Applicable
polypeptide ENSMUSP00000022964 Ensembl | MGI Sequence Detail 213 Not Applicable
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 31
    cDNA 30
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2146065
References
more
  • Summaries
    All 50
    Developmental Gene Expression 8
    Gene Ontology 6
    Phenotypes 17
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:351223 Azuma K, et al., EBAG9-deficient mice display decreased bone mineral density with suppressed autophagy. iScience. 2024 Feb 16;27(2):108871
TSS for Ebag9:
(View these features in JBrowse)
Transcription Start Site Location Distance from Gene 5'-end
Tssr131233 Chr15:44482667-44482724 (+) 125 bp
Tssr131234 Chr15:44482947-44483026 (+) 416 bp
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. last database update
10/07/2025
MGI 6.24 The Jackson Laboratory
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