Grm8 MGI Mouse Gene Detail - MGI:1351345 - glutamate receptor, metabotropic 8

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Grm8 Gene Detail
Summary
  • Symbol
    Grm8
  • Name
    glutamate receptor, metabotropic 8
  • Synonyms
    Gprc1h, mGluR8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351345
    NCBI Gene: 14823
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:27275120-28135094 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 6, 11.97 cM, cytoband A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    22844 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351345
protein coding gene Chr6:27275118-28135177 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030505
protein coding gene Chr6:24942767-25841818 (-)
A/J MGP_AJ_G0030478
protein coding gene Chr6:23872596-24752971 (-)
AKR/J MGP_AKRJ_G0030405
protein coding gene Chr6:24691250-25576715 (-)
BALB/cJ MGP_BALBcJ_G0030488
protein coding gene Chr6:24044043-24914043 (-)
C3H/HeJ MGP_C3HHeJ_G0030201
protein coding gene Chr6:24681601-25566677 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030942
protein coding gene Chr6:25695507-26627435 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028153
protein coding gene Chr6:22142957-22978447 (-)
CAST/EiJ MGP_CASTEiJ_G0029603
protein coding gene Chr6:24436823-25364806 (-)
CBA/J MGP_CBAJ_G0030179
protein coding gene Chr6:26623217-27588453 (-)
DBA/2J MGP_DBA2J_G0030323
protein coding gene Chr6:23844907-24712254 (-)
FVB/NJ MGP_FVBNJ_G0030277
protein coding gene Chr6:23612025-24467394 (-)
LP/J MGP_LPJ_G0030410
protein coding gene Chr6:25076917-25970930 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030313
protein coding gene Chr6:29076039-30142937 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030972
protein coding gene Chr6:24555489-25450389 (-)
PWK/PhJ MGP_PWKPhJ_G0029317
protein coding gene Chr6:23355057-24239383 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029153
protein coding gene Chr6:24237660-25145259 (-)
WSB/EiJ MGP_WSBEiJ_G0029679
protein coding gene Chr6:24519683-25417070 (-)



Homology
more
  • Human Ortholog
    GRM8, glutamate metabotropic receptor 8
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRM8, glutamate metabotropic receptor 8
  • Synonyms
    GLUR8, GPRC1H, mGlu8, MGLUR8
  • Links
    NCBI Gene ID: 2918
    UniProt: O00222

  • Chr Location
    7q31.33; chr7:126438598-127253093 (-) GRCh38
Human Diseases
more
  • Diseases
    4 with human GRM8 associations

Human Disease Mouse Models
IDs
alcohol dependence
IDs
attention deficit hyperactivity disorder
IDs
autistic disorder

DOID:12849
EFO:0003758
ICD10CM:F84.0
ICD9CM:299.0
MESH:D001321
NCI:C97161
OMIM:209850
ORDO:106
UMLS_CUI:C0004352
IDs
schizophrenia

DOID:5419
DOID:14734
ICD10CM:F20
ICD9CM:295
ICD9CM:295.8
ICD9CM:295.80
ICD9CM:295.9
ICD9CM:295.90
MESH:D012559
NCI:C3362
OMIM:181500
UMLS_CUI:C0036341
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 4 alleles in 4 genetic backgrounds
    26 phenotype references
Phenotype Overview

Phenotype Overview
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.
adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are overweight and mildly insulin resistant, and display increased anxiety-related responses and reduced exploration in a new environment. Mice homozygous for a different knock-out allele exhibit altered excitatory responses in the dentate gyrus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
  • Blue cells = expressed in wild-type.
    Gray triangles = other expression annotations only
    (e.g. absence of expression or data from mutants).
early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14823 NCBI Gene Model | MGI Sequence Detail 859975 C57BL/6J ± kb
    transcript NM_001361125 RefSeq | MGI Sequence Detail 3734 C57BL/6
    polypeptide P47743 UniProt | EBI | MGI Sequence Detail 908 Not Applicable
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000008270 metabotropic glutamate receptor 8
    • InterPro Domains
      IPR000337 GPCR, family 3
      IPR017979 GPCR, family 3, conserved site
      IPR017978 GPCR family 3, C-terminal
      IPR000162 GPCR, family 3, metabotropic glutamate receptor
      IPR001786 GPCR, family 3, metabotropic glutamate receptor 4
      IPR000144 GPCR, family 3, metabotropic glutamate receptor 8
      IPR011500 GPCR, family 3, nine cysteines domain
      IPR038550 GPCR, family 3, nine cysteines domain superfamily
      IPR050726 Metabotropic Glutamate Receptor
      IPR028082 Periplasmic binding protein-like I
      IPR001828 Receptor, ligand binding region
    • GlyGen
      P47743 7 sites, 3 N-linked glycans (4 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 13
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-39599, MGI:109600
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 12
      Gene Ontology 12
      Phenotypes 26
    • Earliest
      J:24532 Duvoisin RM, et al., A novel metabotropic glutamate receptor expressed in the retina and olfactory bulb. J Neurosci. 1995 Apr;15(4):3075-83
    • Latest
      J:357284 Lo Giudice Q, et al., Developmental emergence of first- and higher-order thalamic neuron molecular identities. Development. 2024 Sep 15;151(18)
    TSS for Grm8:
    (View these features in JBrowse)
    Transcription Start Site Location Distance from Gene 5'-end
    Tssr60021 Chr6:28135080-28135110 (-) -1 bp
    Tssr60020 Chr6:28134354-28134384 (-) 725 bp
    Tssr60019 Chr6:28133903-28133933 (-) 1,176 bp
    Tssr60018 Chr6:27810129-27810170 (-) 324,944 bp
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support. last database update
    10/07/2025
    MGI 6.24 The Jackson Laboratory
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