Tnfsf13b MGI Mouse Gene Detail - MGI:1344376 - tumor necrosis factor (ligand) superfamily, member 13b

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Tnfsf13b Gene Detail
Summary
  • Symbol
    Tnfsf13b
  • Name
    tumor necrosis factor (ligand) superfamily, member 13b
  • Synonyms
    BAFF, BLyS, D8Ertd387e, TALL-1, zTNF4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344376
    NCBI Gene: 24099
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:10056637-10086000 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 8, 4.55 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    855 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344376
protein coding gene Chr8:10056467-10089072 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033348
protein coding gene Chr8:7146995-7178094 (+)
A/J MGP_AJ_G0033328
protein coding gene Chr8:6900384-6929762 (+)
AKR/J MGP_AKRJ_G0033259
protein coding gene Chr8:7116312-7144851 (+)
BALB/cJ MGP_BALBcJ_G0033329
protein coding gene Chr8:7041421-7069912 (+)
C3H/HeJ MGP_C3HHeJ_G0033042
protein coding gene Chr8:7276952-7306625 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033841
protein coding gene Chr8:7452666-7484522 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030811
protein coding gene Chr8:6447978-6476996 (+)
CAST/EiJ MGP_CASTEiJ_G0032364
protein coding gene Chr8:6954405-6985514 (+)
CBA/J MGP_CBAJ_G0033015
protein coding gene Chr8:7758186-7791384 (+)
DBA/2J MGP_DBA2J_G0033168
protein coding gene Chr8:6899950-6929886 (+)
FVB/NJ MGP_FVBNJ_G0033117
protein coding gene Chr8:6849331-6878249 (+)
LP/J MGP_LPJ_G0033262
protein coding gene Chr8:7062108-7093171 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033151
protein coding gene Chr8:8120411-8163923 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033858
protein coding gene Chr8:7114166-7144349 (+)
PWK/PhJ MGP_PWKPhJ_G0032077
protein coding gene Chr8:6856442-6885650 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031919
protein coding gene Chr8:7022724-7057934 (+)
WSB/EiJ MGP_WSBEiJ_G0032480
protein coding gene Chr8:7160008-7190562 (+)



Homology
more
  • Human Ortholog
    TNFSF13B, TNF superfamily member 13b
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNFSF13B, TNF superfamily member 13b
  • Synonyms
    BAFF, BLYS, CD257, DTL, TALL-1, TALL1, THANK, TNFSF20, TNLG7A, ZTNF4
  • Links
    NCBI Gene ID: 10673
    UniProt: Q9Y275

  • Chr Location
    13q33.3; chr13:108251240-108308484 (+) GRCh38
Human Diseases
more
  • Diseases
    2 with Tnfsf13b mouse models

Human Disease Mouse Models
IDs
IgA glomerulonephritis
View 1 model
Mouse Models

Human Disease Modeled: IgA glomerulonephritis

Allelic Composition Genetic Background Reference Phenotypes
Tg(Tnfsf13b)1Fma/Tg(Tnfsf13b)1Fma
involves: C57BL/6 * DBA/2 J:178227 View
IDs
Sjogren's syndrome

DOID:12894
DOID:416
ICD10CM:M35.0
ICD9CM:710.2
MESH:D012859
NCI:C26883
NCI:C70647
OMIM:270150
UMLS_CUI:C0086981
UMLS_CUI:C1527336

 View 1 model
Mouse Models

Human Disease Modeled: Sjogren's syndrome

Allelic Composition Genetic Background Reference Phenotypes
Tg(Tnfsf13b)1Fma/0
 B6.Cg-Tg(Tnfsf13b)1Fma J:73711 View
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    79 phenotypes from 7 alleles in 11 genetic backgrounds
    37 phenotypes from multigenic genotypes
    91 phenotype references
Phenotype Overview

Phenotype Overview
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.
adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice have reduced number of B cells and reduced levels of immunoglobulins.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
  • Blue cells = expressed in wild-type.
    Gray triangles = other expression annotations only
    (e.g. absence of expression or data from mutants).
early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
    2
  • Comparison Matrix
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 24099 NCBI Gene Model | MGI Sequence Detail 29364 C57BL/6J ± kb
    transcript NR_189032 RefSeq | MGI Sequence Detail 1753 C57BL/6
    polypeptide Q9WU72 UniProt | EBI | MGI Sequence Detail 309 Not Applicable
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 15
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1196237
    References
    more
    • Summaries
      All 184
      Developmental Gene Expression 2
      Diseases 3
      Gene Ontology 12
      Phenotypes 91
    • Earliest
      J:55624 Schneider P, et al., BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. J Exp Med. 1999 Jun 7;189(11):1747-56
    • Latest
      J:361138 Diehl C, et al., Hyperreactive B cells instruct their elimination by T cells to curb autoinflammation and lymphomagenesis. Immunity. 2025 Jan 14;58(1):124-142.e15
    TSS for Tnfsf13b:
    (View these features in JBrowse)
    Transcription Start Site Location Distance from Gene 5'-end
    Tssr76168 Chr8:10056428-10056455 (+) -195 bp
    Tssr76169 Chr8:10056631-10056653 (+) 5 bp
    Tssr76170 Chr8:10056656-10056702 (+) 42 bp
    Tssr76171 Chr8:10056784-10056810 (+) 160 bp
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support. last database update
    10/07/2025
    MGI 6.24 The Jackson Laboratory
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