Zfpm2 MGI Mouse Gene Detail - MGI:1334444 - zinc finger protein, multitype 2

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Zfpm2 Gene Detail
Summary
  • Symbol
    Zfpm2
  • Name
    zinc finger protein, multitype 2
  • Synonyms
    B330005D23Rik, FOG-2, FOG2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1334444
    NCBI Gene: 22762
  • Alliance
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:40518438-40967988 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 15, 15.74 cM, cytoband C
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    11154 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1334444
protein coding gene Chr15:40518431-40967988 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021820
protein coding gene Chr15:39124620-39602716 (+)
A/J MGP_AJ_G0021780
protein coding gene Chr15:37620007-38070741 (+)
AKR/J MGP_AKRJ_G0021761
protein coding gene Chr15:38744519-39198065 (+)
BALB/cJ MGP_BALBcJ_G0021787
protein coding gene Chr15:37676024-38150056 (+)
C3H/HeJ MGP_C3HHeJ_G0021561
protein coding gene Chr15:38636517-39107706 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022226
protein coding gene Chr15:40632589-41135156 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019763
protein coding gene Chr15:35331741-35769613 (+)
CAST/EiJ MGP_CASTEiJ_G0021078
protein coding gene Chr15:39132369-39605568 (+)
CBA/J MGP_CBAJ_G0021530
protein coding gene Chr15:42040808-42547246 (+)
DBA/2J MGP_DBA2J_G0021654
protein coding gene Chr15:37456888-37910454 (+)
FVB/NJ MGP_FVBNJ_G0021632
protein coding gene Chr15:36819702-37257882 (+)
LP/J MGP_LPJ_G0021724
protein coding gene Chr15:38934991-39399784 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021656
protein coding gene Chr15:45035331-45547598 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022249
protein coding gene Chr15:38904027-39385997 (+)
PWK/PhJ MGP_PWKPhJ_G0020823
protein coding gene Chr15:37507097-37959012 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020660
protein coding gene Chr15:38544823-39018841 (+)
WSB/EiJ MGP_WSBEiJ_G0021133
protein coding gene Chr15:38813935-39283603 (+)



Homology
more
  • Human Ortholog
    ZFPM2, zinc finger protein, FOG family member 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZFPM2, zinc finger protein, FOG family member 2
  • Synonyms
    DIH3, FOG2, hFOG-2, SRXY9, ZC2HC11B, ZNF89B
  • Links
    NCBI Gene ID: 23414
    UniProt: Q8WW38

  • Chr Location
    8q23.1; chr8:104590733-105804539 (+) GRCh38
Human Diseases
more
  • Diseases
    3 with Zfpm2 mouse models; 4 with human ZFPM2 associations

Human Disease Mouse Models
IDs
congenital diaphragmatic hernia
View 1 model
Mouse Models

Human Disease Modeled: congenital diaphragmatic hernia

Allelic Composition Genetic Background Reference Phenotypes
Zfpm2lil/Zfpm2lil
involves: A/J J:100119 View
IDs
tetralogy of Fallot

DOID:6419
ICD10CM:Q21.3
ICD9CM:745.2
MESH:D013771
NCI:C84505
OMIM:187500
UMLS_CUI:C0039685

 View 1 model
Mouse Models

Human Disease Modeled: tetralogy of Fallot

Allelic Composition Genetic Background Reference Phenotypes
Zfpm2tm1Sho/Zfpm2tm1Sho
involves: 129S1/Sv J:62879 J:78688 View
IDs
 View 1 model
Mouse Models

Human Disease Modeled: tricuspid atresia

Allelic Composition Genetic Background Reference Phenotypes
Zfpm2tm1Jml/Zfpm2tm1Jml
involves: 129X1/SvJ J:63121 View
IDs
46,XY sex reversal 9
IDs
myelodysplastic syndrome
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    80 phenotypes from 6 alleles in 13 genetic backgrounds
    9 phenotypes from multigenic genotypes
    9 images
    39 phenotype references
Phenotype Overview

Phenotype Overview
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.
adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit cardiac defects, including absence of coronary vasculature, resulting in lethality between E12.5 and E15.5. Conditional mutations reveal errors in ovary and testis development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
  • Blue cells = expressed in wild-type.
    Gray triangles = other expression annotations only
    (e.g. absence of expression or data from mutants).
early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22762 NCBI Gene Model | MGI Sequence Detail 449551 C57BL/6J ± kb
    transcript NM_011766 RefSeq | MGI Sequence Detail 4974 ZRU/MplStud
    polypeptide Q8CCH7 UniProt | EBI | MGI Sequence Detail 1151 Not Applicable
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 49
      cDNA 30
      Primer pair 11
      Other 8

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2444606
    References
    more
    • Summaries
      All 136
      Developmental Gene Expression 75
      Diseases 4
      Gene Ontology 21
      Phenotypes 39
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:365688 Broman MT, et al., A Genomic Link From Heart Failure to Atrial Fibrillation Risk: FOG2 Modulates a TBX5/GATA4-Dependent Atrial Gene Regulatory Network. Circulation. 2024 Apr 9;149(15):1205-1230
    TSS for Zfpm2:
    (View these features in JBrowse)
    Transcription Start Site Location Distance from Gene 5'-end
    Tssr131170 Chr15:40518277-40518287 (+) -156 bp
    Tssr131171 Chr15:40518308-40518317 (+) -125 bp
    Tssr131172 Chr15:40518390-40518400 (+) -43 bp
    Tssr131173 Chr15:40518416-40518450 (+) -5 bp
    Tssr131174 Chr15:40518465-40518478 (+) 34 bp
    Tssr131175 Chr15:40518604-40518621 (+) 175 bp
    Tssr131176 Chr15:40518655-40518662 (+) 221 bp
    Tssr4586 Chr15:40518691-40518698 (+) 257 bp
    Tssr131177 Chr15:40518704-40518717 (+) 273 bp
    Tssr131178 Chr15:40518733-40518753 (+) 305 bp
    Tssr131179 Chr15:40521582-40521589 (+) 3,148 bp
    Tssr131181 Chr15:40598771-40598774 (+) 80,335 bp
    Tssr131182 Chr15:40740878-40740881 (+) 222,442 bp
    Tssr131183 Chr15:40832720-40832723 (+) 314,284 bp
    Tssr131184 Chr15:40857323-40857333 (+) 338,890 bp
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support. last database update
    10/07/2025
    MGI 6.24 The Jackson Laboratory
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