Atp9a MGI Mouse Gene Detail - MGI:1330826 - ATPase, class II, type 9A

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Atp9a Gene Detail
Summary
  • Symbol
    Atp9a
  • Name
    ATPase, class II, type 9A
  • Synonyms
    Class II, IIa, mKIAA0611
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330826
    NCBI Gene: 11981
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:168476358-168584290 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 88.99 cM, cytoband H3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3948 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330826
protein coding gene Chr2:168476358-168584329 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026928
protein coding gene Chr2:174491374-174627886 (-)
A/J MGP_AJ_G0026895
protein coding gene Chr2:167270890-167383836 (-)
AKR/J MGP_AKRJ_G0026866
protein coding gene Chr2:172266622-172384236 (-)
BALB/cJ MGP_BALBcJ_G0026904
protein coding gene Chr2:167632362-167746050 (-)
C3H/HeJ MGP_C3HHeJ_G0026646
protein coding gene Chr2:172632449-172755419 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027351
protein coding gene Chr2:179560583-179711132 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024722
protein coding gene Chr2:160580591-160690516 (-)
CAST/EiJ MGP_CASTEiJ_G0026104
protein coding gene Chr2:173130855-173258806 (-)
CBA/J MGP_CBAJ_G0026623
protein coding gene Chr2:186177260-186318316 (-)
DBA/2J MGP_DBA2J_G0026761
protein coding gene Chr2:166371962-166486183 (-)
FVB/NJ MGP_FVBNJ_G0026727
protein coding gene Chr2:164947931-165060758 (-)
LP/J MGP_LPJ_G0026862
protein coding gene Chr2:174499577-174621658 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026746
protein coding gene Chr2:189458952-189582748 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027408
protein coding gene Chr2:172195892-172315931 (-)
PWK/PhJ MGP_PWKPhJ_G0025841
protein coding gene Chr2:166068292-166178571 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025642
protein coding gene Chr2:171166079-171289480 (-)
WSB/EiJ MGP_WSBEiJ_G0026177
protein coding gene Chr2:173110716-173238020 (-)



Homology
more
  • Human Ortholog
    ATP9A, ATPase phospholipid transporting 9A (putative)
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATP9A, ATPase phospholipid transporting 9A (putative)
  • Synonyms
    ATPIIA, NEDGBA
  • Links
    NCBI Gene ID: 10079
    UniProt: O75110

  • Chr Location
    20q13.2; chr20:51596514-51768390 (-) GRCh38
Human Diseases
more
  • Diseases
    1 with Atp9a mouse models; 1 with human ATP9A associations

Human Disease Mouse Models
IDs
neurodevelopmental disorder with poor growth and behavioral abnormalities
View 1 model
Mouse Models

Human Disease Modeled: neurodevelopmental disorder with poor growth and behavioral abnormalities

Allelic Composition Genetic Background Reference Phenotypes
Atp9aem1Bcgen/Atp9aem1Bcgen
involves: C57BL/6 J:335674 View
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

Phenotype Overview
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.
adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show decreased muscle strength, learning and memory deficits, hyperkinetic movement disorder, abnormal neurite morphology and impaired synaptic transmission in the motor cortex and hippocampus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
  • Blue cells = expressed in wild-type.
    Gray triangles = other expression annotations only
    (e.g. absence of expression or data from mutants).
early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
    5
  • Comparison Matrix
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11981 NCBI Gene Model | MGI Sequence Detail 107933 C57BL/6J ± kb
    transcript NM_001354978 RefSeq | MGI Sequence Detail 3868 C57BL/6
    polypeptide O70228 UniProt | EBI | MGI Sequence Detail 1047 Not Applicable
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 202
      cDNA 200
      Primer pair 2

      Microarray probesets 6
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 10
      Phenotypes 14
    • Earliest
      J:47134 Halleck MS, et al., Multiple members of a third subfamily of P-type ATPases identified by genomic sequences and ESTs. Genome Res. 1998 Apr;8(4):354-61
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    TSS for Atp9a:
    (View these features in JBrowse)
    Transcription Start Site Location Distance from Gene 5'-end
    Tssr27867 Chr2:168584020-168584062 (-) 249 bp
    Tssr27866 Chr2:168583896-168583913 (-) 385 bp
    Tssr27865 Chr2:168583818-168583893 (-) 434 bp
    Tssr27864 Chr2:168583770-168583790 (-) 510 bp
    Tssr27863 Chr2:168583672-168583694 (-) 607 bp
    Tssr27862 Chr2:168576156-168576206 (-) 8,109 bp
    Tssr27861 Chr2:168575980-168576055 (-) 8,272 bp
    Tssr27860 Chr2:168564467-168564469 (-) 19,822 bp
    Tssr27859 Chr2:168554773-168554855 (-) 29,476 bp
    Tssr27858 Chr2:168512312-168512345 (-) 71,961 bp
    Tssr27857 Chr2:168512008-168512022 (-) 72,275 bp
    Tssr27856 Chr2:168511972-168512004 (-) 72,302 bp
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support. last database update
    10/07/2025
    MGI 6.24 The Jackson Laboratory
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