Cdk2 MGI Mouse Gene Detail - MGI:104772 - cyclin dependent kinase 2

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Cdk2 Gene Detail
Summary
  • Symbol
    Cdk2
  • Name
    cyclin dependent kinase 2
  • Synonyms
    A630093N05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:104772
    NCBI Gene: 12566
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:128533808-128540900 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 10, 77.13 cM, cytoband D3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    192 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104772
protein coding gene Chr10:128533807-128540920 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017878
protein coding gene Chr10:132467001-132474132 (-)
A/J MGP_AJ_G0017853
protein coding gene Chr10:127147772-127154891 (-)
AKR/J MGP_AKRJ_G0017816
protein coding gene Chr10:130863745-130870860 (-)
BALB/cJ MGP_BALBcJ_G0017817
protein coding gene Chr10:127514576-127521703 (-)
C3H/HeJ MGP_C3HHeJ_G0017640
protein coding gene Chr10:131034900-131042049 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018272
protein coding gene Chr10:136940322-136947438 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015950
protein coding gene Chr10:121062406-121069943 (-)
CAST/EiJ MGP_CASTEiJ_G0017201
protein coding gene Chr10:131756422-131763543 (-)
CBA/J MGP_CBAJ_G0017610
protein coding gene Chr10:142528437-142539487 (-)
DBA/2J MGP_DBA2J_G0017716
protein coding gene Chr10:126209599-126216710 (-)
FVB/NJ MGP_FVBNJ_G0017711
protein coding gene Chr10:125132628-125139781 (-)
LP/J MGP_LPJ_G0017790
protein coding gene Chr10:133057204-133064362 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017739
protein coding gene Chr10:145094785-145103169 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018312
protein coding gene Chr10:130970983-130978095 (-)
PWK/PhJ MGP_PWKPhJ_G0016986
protein coding gene Chr10:126463588-126470729 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016775
protein coding gene Chr10:130081689-130088791 (-)
WSB/EiJ MGP_WSBEiJ_G0017260
protein coding gene Chr10:131191184-131198939 (-)



Homology
more
  • Human Ortholog
    CDK2, cyclin dependent kinase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDK2, cyclin dependent kinase 2
  • Synonyms
    CDKN2, p33(CDK2)
  • Links
    NCBI Gene ID: 1017
    UniProt: P24941

  • Chr Location
    12q13.2; chr12:55966781-55972789 (+) GRCh38
Human Diseases
more
  • Diseases
    2 with human CDK2 associations

Human Disease Mouse Models
IDs
IDs
renal cell carcinoma
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    34 phenotypes from 3 alleles in 4 genetic backgrounds
    59 phenotypes from multigenic genotypes
    65 phenotype references
Phenotype Overview

Phenotype Overview
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.
adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Reproductive system abnormalities are observed in mice homozygous for disruptions in this gene. Gametogenesis fails in both males and females, leading to atrophy of the testes and ovaries. Both sexes are sterile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
  • Blue cells = expressed in wild-type.
    Gray triangles = other expression annotations only
    (e.g. absence of expression or data from mutants).
early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025358 Ensembl Gene Model | MGI Sequence Detail 7093 C57BL/6J ± kb
    transcript ENSMUST00000026416 Ensembl | MGI Sequence Detail 2406 Not Applicable
    polypeptide ENSMUSP00000026416 Ensembl | MGI Sequence Detail 346 Not Applicable
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 102
      cDNA 97
      Primer pair 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-28064, MGI:2443873
    References
    more
    • Summaries
      All 273
      Developmental Gene Expression 80
      Gene Ontology 35
      Phenotypes 65
    • Earliest
      J:19954 Tsai LH, et al., Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase. Nature. 1991 Sep 12;353(6340):174-7
    • Latest
      J:361445 Ito M, et al., Distinct and interdependent functions of three RING proteins regulate recombination during mammalian meiosis. Proc Natl Acad Sci U S A. 2025 Jan 14;122(2):e2412961121
    TSS for Cdk2:
    (View these features in JBrowse)
    Transcription Start Site Location Distance from Gene 5'-end
    Tssr99932 Chr10:128540847-128540918 (-) 17 bp
    Tssr99931 Chr10:128540816-128540844 (-) 70 bp
    Tssr99930 Chr10:128540154-128540180 (-) 733 bp
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support. last database update
    10/07/2025
    MGI 6.24 The Jackson Laboratory
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