Ptger4 MGI Mouse Gene Detail - MGI:104311 - prostaglandin E receptor 4 (subtype EP4)

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Ptger4 Gene Detail
Summary
  • Symbol
    Ptger4
  • Name
    prostaglandin E receptor 4 (subtype EP4)
  • Synonyms
    EP4, Ptgerep4
  • Feature Type
    protein coding gene
  • IDs
    MGI:104311
    NCBI Gene: 19219
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:5262880-5273668 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 15, 1.99 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    305 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104311
protein coding gene Chr15:5236142-5273668 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021694
protein coding gene Chr15:2115050-2157686 (-)
A/J MGP_AJ_G0021655
protein coding gene Chr15:2123867-2161146 (-)
AKR/J MGP_AKRJ_G0021633
protein coding gene Chr15:2100483-2136387 (-)
BALB/cJ MGP_BALBcJ_G0021662
protein coding gene Chr15:2049534-2086540 (-)
C3H/HeJ MGP_C3HHeJ_G0021438
protein coding gene Chr15:2125768-2165020 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022101
protein coding gene Chr15:2221833-2260228 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019638
protein coding gene Chr15:1859984-1896809 (-)
CAST/EiJ MGP_CASTEiJ_G0020954
protein coding gene Chr15:2112613-2151849 (-)
CBA/J MGP_CBAJ_G0021407
protein coding gene Chr15:2254402-2303183 (-)
DBA/2J MGP_DBA2J_G0021531
protein coding gene Chr15:2056243-2093532 (-)
FVB/NJ MGP_FVBNJ_G0021509
protein coding gene Chr15:1994151-2030279 (-)
LP/J MGP_LPJ_G0021599
protein coding gene Chr15:2051350-2092631 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021534
protein coding gene Chr15:2382395-2423516 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022124
protein coding gene Chr15:2113400-2149986 (-)
PWK/PhJ MGP_PWKPhJ_G0020697
protein coding gene Chr15:2076380-2112734 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020535
protein coding gene Chr15:2064605-2101419 (-)
WSB/EiJ MGP_WSBEiJ_G0021010
protein coding gene Chr15:2052743-2090961 (-)



Homology
more
  • Human Ortholog
    PTGER4, prostaglandin E receptor 4
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTGER4, prostaglandin E receptor 4
  • Synonyms
    EP4, EP4R
  • Links
    NCBI Gene ID: 5734
    UniProt: P35408

  • Chr Location
    5p13.1; chr5:40679915-40746800 (+) GRCh38
Human Diseases
more
  • Diseases
    1 with Ptger4 mouse models; 3 with human PTGER4 associations

Human Disease Mouse Models
IDs
dilated cardiomyopathy
View 1 model
Mouse Models

Human Disease Modeled: dilated cardiomyopathy

Allelic Composition Genetic Background Reference Phenotypes
Ptger4tm1.1Matb/Ptger4tm1.1Matb
Tg(Myh6-cre)2182Mds/0
 involves: 129S6/SvEvTac * FVB/N J:158439 View
IDs
ankylosing spondylitis

DOID:7147
EFO:0003898
ICD10CM:M45
ICD9CM:720.0
MESH:D013167
NCI:C84564
OMIM:PS106300
ORDO:825
UMLS_CUI:C0038013
IDs
arteriosclerosis

DOID:2349
ICD10CM:I70
MESH:D001161
NCI:C34398
UMLS_CUI:C0003850
IDs
ulcerative colitis

DOID:8577
DOID:8576
DOID:9016
EFO:0000729
ICD10CM:K51
ICD9CM:556
ICD9CM:556.5
ICD9CM:556.9
MESH:D003093
NCI:C2952
UMLS_CUI:C0009324
UMLS_CUI:C0375359
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    58 phenotypes from 5 alleles in 7 genetic backgrounds
    118 phenotype references
Phenotype Overview

Phenotype Overview
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.
adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Most homozygous targeted null mutants die shortly after birth due to failed closure of the ductus arteriosis. Survivors show decreased migration of Langerhans cells to lymph nodes, contact hypersensitivity and decreased incidence of induced arthritis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
  • Blue cells = expressed in wild-type.
    Gray triangles = other expression annotations only
    (e.g. absence of expression or data from mutants).
early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19219 NCBI Gene Model | MGI Sequence Detail 10789 C57BL/6J ± kb
    transcript NM_001136079 RefSeq | MGI Sequence Detail 3327 ZRU/MplStud
    polypeptide P32240 UniProt | EBI | MGI Sequence Detail 513 Not Applicable
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 3
      cDNA 19
      Primer pair 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-25639
    References
    more
    • Summaries
      All 200
      Developmental Gene Expression 15
      Diseases 1
      Gene Ontology 15
      Phenotypes 118
    • Earliest
      J:25578 Fuller JL, et al., Effects of retinal degeneration and brain size upon spatial reversal learning in mice. Percept Mot Skills. 1973 Jun;36(3):947-50
    • Latest
      J:373006 Xu H, et al., Targeting the E Prostanoid Receptor EP4 Mitigates Cardiac Fibrosis Induced by beta-Adrenergic Activation. Adv Sci (Weinh). 2025 Mar;12(12):e2413324
    TSS for Ptger4:
    (View these features in JBrowse)
    Transcription Start Site Location Distance from Gene 5'-end
    Tssr133618 Chr15:5273659-5273673 (-) 2 bp
    Tssr133617 Chr15:5273645-5273656 (-) 17 bp
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support. last database update
    10/07/2025
    MGI 6.24 The Jackson Laboratory
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