Research Library: Scientific Articles, Monographs, and More

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 [post_date] => 2025年11月21日 09:39:34
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 [post_content] => 

			Abstract	
	
Background
Early-life exposures might negatively affect fetal and infant development, predisposing children to obesity. This study aimed to systematically identify and evaluate risk factors for childhood obesity in preconception, pregnancy, and infancy, and assess their potential for future prediction and prevention strategies.
Methods
This systematic review (PROSPERO, CRD42022355152) included longitudinal studies from selected electronic databases published between inception and August 17th, 2022, identifying maternal, paternal, or infant risk factors from preconception until infancy for childhood obesity between 2 and 18 years. Screening and data extraction were conducted using standardized forms. We assessed risk factor quality on modifiability and predictive power using a piloted criteria template from ILSI-Europe-Marker-Validation-Initiative.
Findings
We identified 172 publications from observational and five publications from intervention studies involving n = 1,879,971 children from 37, predominantly high-income, countries. Average reported childhood obesity prevalence was 11.1%. Pregnancy and infancy risk factors were mostly studied. We identified 59 potential risk factors; 23 were consistently associated. Strongest risk factors were: higher maternal prepregnancy weight (n = 28/31 publications with positive associations), higher gestational weight gain (n = 18/21), maternal smoking during pregnancy (n = 23/29), higher birth weight (n = 20/28), large-size-for-gestational-age-at-birth (n = 17/18), no breastfeeding (n = 20/31), and higher infant weight gain (n = 12/12). Level of evidence was generally moderate due to unreliable exposure measurement, short follow-up/loss to follow-up, and risk of confounding.
Interpretation
We identified seven early-life risk factors, which were strongly associated with childhood obesity, and can contribute to future prediction and prevention strategies. These findings support the implementation of prevention strategies targeting these risk factors from a clinical and population perspective, where possible integrated with implementation studies.

			One pager	
				
				Expert group Early Biomarker one-pager (1)-1
				
			
						Read the full paper
					
	
Commissioned by the Early Nutrition and Long-Term Health Task Force 
 [post_title] => Risk Factors in the First 1000 Days of Life Associated With Childhood Obesity: A Systematic Review and Risk Factor Quality Assessment
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 [post_date] => 2025年11月21日 10:07:53
 [post_date_gmt] => 2025年11月21日 10:07:53
 [post_content] => 

			Abstract	
	
This Review Article summarizes outcomes from the ILSI Europe expert workshop on plant-based proteins in infant formula, held in November 2024. Experts from academia, clinical nutrition, and food science evaluated the current use and future potential of plant-based protein sources in infant formula, considering nutritional adequacy, allergenicity, sustainability, processing technologies, and regulatory constraints. While soy and hydrolyzed rice proteins are already approved and in use, emerging sources such as pea, lentil, and faba beans show promise but require further validation of their amino acid profiles, digestibility, safety, and suitability for infants. Key research priorities identified include the development of improved protein extraction methods, in vitro digestion and allergy modeling, and targeted clinical studies. This review synthesizes current evidence and expert perspectives to support the development of sustainable, nutritionally adequate plant-based infant formulas.

			One pager	
				
				Expert group Plant-based protien one-pager-1
				
			
						Read the full paper
					
	
Commissioned by the Early Nutrition and Long-Term Health Task Force 
 [post_title] => Plant-based proteins for infant formula: findings and recommendations from the ILSI Europe workshop
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 [post_modified] => 2025年11月21日 05:07:54
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 [2] => WP_Post Object
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 [ID] => 52216
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 [post_date] => 2025年10月23日 09:12:08
 [post_date_gmt] => 2025年10月23日 13:12:08
 [post_content] => 

			Abstract	
	
At the end of October 2024, ILSI Europe brought together industry and academic experts from different fields to identify research gaps and challenges in nutritional interventions supporting healthy ageing. The objectives of the Healthy Ageing Working Group workshop were to address the urgent need to define ageing outcomes and associated biomarkers, determine the trajectory of functional ageing across the lifespan, and leverage technology to tailor nutritional and lifestyle interventions for healthy ageing. This brief report presents the key points highlighted during this workshop.
			
						Read the full paper
					
	
Commissioned by the Healthy Agein Task Force 
 [post_title] => Building a roadmap to nutrition for Healthy Ageing: a brief report on the ILSI Europe Healthy Ageing Task Force
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 [post_modified] => 2025年10月23日 11:07:31
 [post_modified_gmt] => 2025年10月23日 15:07:31
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 [post_date] => 2025年10月10日 10:13:35
 [post_date_gmt] => 2025年10月10日 10:13:35
 [post_content] => 

			Abstract	
	
In its simplest form, risk is the product of hazard, i.e. toxic potency of a chemical substance, and exposure, or dose. Hazard-based decision-making is based solely on hazard without any consideration of exposure. The development of mitigation strategies should prioritise mycotoxins that regularly occur at undesirable levels in commonly consumed commodities, wherein both the toxicological profiles and effectiveness of mitigation are understood with a reasonable degree of certainty. This manuscript presents a framework for risk prioritisation of mycotoxins in food, integrating hazard assessment, exposure evaluation, and for the first time appraisal of mitigation strategies. More specifically, by (1) identifying the mycotoxins relevant for each food categories, by (2) assigning a severity score for the pivotal effect of each mycotoxin; by (3) calculating the respective food-categories' contributions to the combined exposures and by (4) assessing the existing mitigation strategies, the framework aims to prioritise mycotoxins based on their health risks and potential for effective risk mitigation. As a proof of concept, the framework was applied in two wheat-based food commodities - bread and pasta -, focusing on Ochratoxin A (OTA), Deoxynivalenol (DON), and Zearalenone (ZEN), revealing that OTA in bread is the highest priority concern, followed by DON in bread.

			Publication one-pager	
				
				FC TF - NT One Pager
				
			
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Commissioned by the Food Contaminants Task Force 
 [post_title] => Framework on risk prioritisation of mycotoxins in food: a case study in two wheat-based products
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 [post_date] => 2025年10月03日 11:45:39
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 [post_title] => ILSI US & Canada Annual Symposium Scientific Report
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 [post_content] => 

			Abstract	
	
Background
Early-life exposures might negatively affect fetal and infant development, predisposing children to obesity. This study aimed to systematically identify and evaluate risk factors for childhood obesity in preconception, pregnancy, and infancy, and assess their potential for future prediction and prevention strategies.
Methods
This systematic review (PROSPERO, CRD42022355152) included longitudinal studies from selected electronic databases published between inception and August 17th, 2022, identifying maternal, paternal, or infant risk factors from preconception until infancy for childhood obesity between 2 and 18 years. Screening and data extraction were conducted using standardized forms. We assessed risk factor quality on modifiability and predictive power using a piloted criteria template from ILSI-Europe-Marker-Validation-Initiative.
Findings
We identified 172 publications from observational and five publications from intervention studies involving n = 1,879,971 children from 37, predominantly high-income, countries. Average reported childhood obesity prevalence was 11.1%. Pregnancy and infancy risk factors were mostly studied. We identified 59 potential risk factors; 23 were consistently associated. Strongest risk factors were: higher maternal prepregnancy weight (n = 28/31 publications with positive associations), higher gestational weight gain (n = 18/21), maternal smoking during pregnancy (n = 23/29), higher birth weight (n = 20/28), large-size-for-gestational-age-at-birth (n = 17/18), no breastfeeding (n = 20/31), and higher infant weight gain (n = 12/12). Level of evidence was generally moderate due to unreliable exposure measurement, short follow-up/loss to follow-up, and risk of confounding.
Interpretation
We identified seven early-life risk factors, which were strongly associated with childhood obesity, and can contribute to future prediction and prevention strategies. These findings support the implementation of prevention strategies targeting these risk factors from a clinical and population perspective, where possible integrated with implementation studies.

			One pager	
				
				Expert group Early Biomarker one-pager (1)-1
				
			
						Read the full paper
					
	
Commissioned by the Early Nutrition and Long-Term Health Task Force 
 [post_title] => Risk Factors in the First 1000 Days of Life Associated With Childhood Obesity: A Systematic Review and Risk Factor Quality Assessment
 [post_excerpt] => 
 [post_status] => publish
 [comment_status] => closed
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