Quizalofop-P-ethyl (Ref: DPX 79376)

---

SUMMARY Hazard alerts

The following Pesticide Hazard Tricolour (PHT) alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement. The alerts for Highly Hazardous Pesticides (HHPs) are based on applying the FAO/WHO (Type 1) and the PAN (Type II) criteria to PPDB data. Further details on the HHP indicators are given in the tables below. Neither the PHT nor the HHP hazard alerts take account of usage patterns or exposure, thus they do not represent risk.

PHT: Environmental fate	PHT: Ecotoxicity	PHT: Human health	Highly Hazardous Pesticide
Environmental fate Moderate alert: Drainflow: Slightly mobile; Potential for particle bound transport: Medium	Ecotoxicity Moderate alert: Birds chronic ecotoxicity: Moderate; Fish acute ecotoxicity: Moderate; Fish chronic ecotoxicity: Moderate; Daphnia acute ecotoxicity: Moderate; Daphnia chronic ecotoxicity: Moderate; Earthworms acute ecotoxicity: Moderate	Human health Moderate alert: Mammals acute toxicity: Moderate; Mammals chronic toxicity: Moderate; Genotoxic; Reproduction/development effects	Highly Hazardous Pesticide (HHP) Type II alert

Description
An post-emergence annual and perennial grass weed herbicide in sugerbeet and other crops
Example pests controlled
Bentgrass; Volunteer cereals; Perennial ryegrass; Italian ryegrass; Couch
Example applications
Sugarbeet; Fodder beet; Winter and spring OSR; Potatoes; Combining peas; Field beans; Other pulses; Linseed; Sunflowers
Efficacy & activity
-

GB regulatory status

GB COPR regulatory status
Approved
Date COPR inclusion expires
30/11/2029
GB LERAP status
None

EC Regulation 1107/2009 (repealing 91/414)

EC Regulation 1107/2009 status
Approved
Dossier rapporteur/co-rapporteur
Finland/Sweden
Date EC 1107/2009 inclusion expires
28/02/2027
EU Candidate for substitution (CfS)
No
Listed in EU database
Yes
Approved for use (✓) under EC 1107/2009 in the following EU Member States
ATAustria BEBelgium BGBulgaria CYCyprus CZCzech Republic DEGermany DKDenmark EEEstonia ELGreece ✓ ✓ ✓ ✓ ✓ ✓   ✓ ✓ ESSpain FIFinland FRFrance HRCroatia HUHungary IEIreland ITItaly LTLithuania LULuxembourg ✓ ✓ ✓ ✓ ✓ ✓   ✓ ✓ LVLatvia MTMalta NLNetherlands PLPoland PTPortugal RORomania SESweden SISlovenia SKSlovakia ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓
Approved for use (✓) under EC 1107/2009 by Mutual Recognition of Authorisation and/or national regulations in the following EEA countries
ISIceland NONorway

Additional information

Also used in
Australia; Morocco

Chemical structure

Isomerism
A chiral molecule. Quizalofop-P-ethyl is the more biologically active (+) enantimer of the racemate quizalofop-ethyl.
Chemical formula
C19H17ClN2O4
Canonical SMILES
CCOC(=O)C(C)OC1=CC=C(C=C1)OC2=CN=C3C=C(C=CC3=N2)Cl
Isomeric SMILES
CCOC(=O)[C@@H](C)OC1=CC=C(C=C1)OC2=CN=C3C=C(C=CC3=N2)Cl
International Chemical Identifier key (InChIKey)
OSUHJPCHFDQAIT-GFCCVEGCSA-N
International Chemical Identifier (InChI)
InChI=1S/C19H17ClN2O4/c1-3-24-19(23)12(2)25-14-5-7-15(8-6-14)26-18-11-21-17-10-13(20)4-9-16(17)22-18/h4-12H,3H2,1-2H3/t12-/m1/s1
2D structure diagram/image available?
Yes

Common Name	Relationship	Link
quizalofop-P-ethyl	-
quizalofop-ethyl	-

General status

Pesticide type
Herbicide
Substance groups
Aryloxyphenoxypropionate herbicide
Minimum active substance purity
95%
Known relevant impurities
-
Substance origin
Synthetic
Mode of action
Selective. Acetyl CoA carboxylase inhibitor (ACCase) - distrupts fatty acid biosynthesis and lipid formation.
CAS RN
100646-51-3
EC number
600-119-3
CIPAC number
641.202
US EPA chemical code
-
PubChem CID
1617113
CLP index number
No data found
Molecular mass
372.81
PIN (Preferred Identification Name)
ethyl (2R)-2-{4-[(6-chloroquinoxalin-2-yl)oxy]phenoxy}propanoate
IUPAC name
ethyl (R)-2-[4-(6-chloroquinoxalin-2-yloxy)phenoxy]propionate
CAS name
ethyl (2R)-2-(4-((6-chloro-2-quinoxalinyl)oxy)phenoxy)propanoate
Global Governance status: Listed (✓) under
UK Poisons List Order 1972 Rotterdam Convention Montreal Protocol XNo The Poisons List Order 1972 XNo Rotterdam Convention XNo Montreal Protocol Stockholm Convention OSPAR EU Water Framework Directive XNo Stockholm Convention XNo OSPAR XNo EU Water Framework Directive
Relevant Environmental Water Quality Standards
-
Forever chemical
-
Highly Hazardous Pesticide (HHP)
	Type I
-
Type II
Yes [ R09 Rule 9: Pesticide active ingredients that have demonstrated a high aquatic toxicity (where acute ecotoxicity for fish, invertebrates or algae =< 0.1 mg l−1) ]
Other status information
Marine pollutant
Herbicide Resistance Class (HRAC MoA class)
A
Herbicide Resistance Class (WSSA MoA class)
1
Insecticide Resistance Class (IRAC MoA class)
Not applicable
Fungicide Resistance Class (FRAC MOA class)
Not applicable
Examples of recorded resistance
Bromus rigidus
Physical state
White crystalline powder
Related substances & organisms
quizalofop quizalofop-ethyl quizalofop-P-tefuryl

Commercial

Property
Value
Availability status
Current
Introduction & key dates
1989, introduced
Example manufacturers & suppliers of products using this active now or historically
Adama Makhteshim Nissan FCC Kingtai Chemicals BOC Sciences
Example products using this active
Leopard EC Pilot Ultra Targa Super Matador
Formulation and application details
Often supplied as emulsifiable or soluble concentrate that is used as a foliar spray
Commercial production
Quizalofop-P-ethyl is commercially produced through a chiral synthesis starting with the etherification of 2,6-dichloroquinoxaline with hydroquinone under basic conditions to form 2-(6-chloroquinoxalin-2-yloxy)phenol, followed by stereoselective alkylation with ethyl (S)-2-bromopropionate (or resolution of the racemic ester via enzymatic or chiral crystallization methods) in the presence of potassium carbonate to yield the active compound.
Impact on climate of production and use
-

Property
Value
Source; quality score; and other information
Interpretation
Solubility - In water at 20 °C at pH 7 (mg l−1)
0.61	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	Low
Solubility - In organic solvents at 20 °C (mg l−1)
		250000	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Acetone	-
		250000	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Ethyl acetate	-
		250000	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Xylene	-
34870	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Methanol	-
Melting point (°C)
75.0	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	-
Boiling point (°C)
Decomposes before boiling	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	-
Degradation point (°C)
320	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	-
Flashpoint (°C)
-	-	-
Octanol-water partition coefficient at pH 7, 20 °C
	P
4.07 X 1004	Calculated	-
Log P
4.61	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	High
Fat solubility of residues
	Solubility
Soluble	A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 4 = Verified data	-
Data type
Regulatory data based on LogP	A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 4 = Verified data	-
Density (g ml−1)
1.301	E4 E = Manufacturers safety data sheets 4 = Verified data	-
Dissociation constant pKa) at 25 °C
		Not applicable	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	-
No dissociation
Vapour pressure at 20 °C (mPa)
1.10 X 10-04	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	Low volatility
Henry's law constant at 25 °C (Pa m3 mol−1)
6.70 X 10-05	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	Non-volatile
Volatilisation as max % of applied dose lost
	From plant surface
0	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes 24 hr	Volatilisation is not considered critical for air pollution
From soil surface
0.3	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes 24 hr	Volatilisation is not considered critical for air pollution
Maximum UV-vis absorption L mol−1 cm−1
Neutral solution 343nm = 6342 Acidic solution 343nm = 6356 Basic solution 343nm = 6242	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	-
Surface tension (mN m−1)
-	-	-

Degradation

Property
Value
Source; quality score; and other information
Interpretation
General biodegradability
-
Soil degradation (days) (aerobic)
	DT50 (typical)
	2	K4 K = Research datasets (e.g. Pandora, Demetra; these datasets no longer available). Norman Ecotoxicology database. (click here ) 4 = Verified data	Non-persistent
	DT50 (lab at 20 °C)
	0.4	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	Non-persistent
	DT50 (field)
	1.8	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	Non-persistent
DT90 (lab at 20 °C)
2	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	Non-persistent
DT90 (field)
5.7	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	-
DT50 modelling endpoint
-	-	-
Note
EU dossier lab studies DT50 range 0.1-1.1 days (normalised), DT90 range 1.1-3.5 days; field studies DT50 range 0.55-8.2 days, DT90 range 1.8-27.4 days
Dissipation rate RL50 (days) on plant matrix
	Value
-	-	-
Note
-
Dissipation rate RL50 (days) on and in plant matrix
	Value
5.6	R3 R = Peer reviewed scientific publications 3 = Unverified data of known source	-
Note
OSR straw, n=1
Aqueous photolysis DT50 (days) at pH 7
	Value
38.3	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	Stable
Note
Data for continuous light, DT50 40.2 days in natural light 40 deg N
Aqueous hydrolysis DT50 (days) at 20 °C and pH 7
	Value
112	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	Persistent
Note
pH and temperature sensitive: Stable at pH 4 and 50 °C, DT50 10.7 days at pH 7 and 40 °C, 4 days at pH 7 and 50 °C, unstable at pH 9 and 50 °C
Water-sediment DT50 (days)
1.51	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	Fast
Water phase only DT50 (days)
1.55	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	Moderately fast
Sediment phase only DT50 (days)
-	-	-
Air degradation
As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT50’. Where data is available, this can be found in the Fate Indices section below.
Decay in stored produce DT50
-

Soil adsorption and mobility

Property
Value
Source; quality score; and other information
Interpretation
Linear
	Kd (mL g−1)
	-	-	-
Koc (mL g−1)
-
Notes and range
-
Freundlich
	Kf (mL g−1)
	49.9	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	Slightly mobile
	Kfoc (mL g−1)
1816
1/n
0.86
Notes and range
EU dossier Kf range 15.4-99.3, Kfoc range 1024-3078 mL g−1, 1/n range 0.83-0.88, Soils=4
pH sensitivity
No

Fate indices Known soil metabolites

Property
Value
Source; quality score; and other information
Interpretation
GUS leaching potential index
0.19	Calculated	Low leachability
SCI-GROW groundwater index (μg l−1) for a 1 kg ha−1 or 1 l ha−1 application rate
	Value
4.67 X 10-04	Calculated	-
Note
-
Potential for particle bound transport index
Medium	Calculated	-
Potential for loss via drain flow
Slightly mobile	Calculated	-
Photochemical oxidative DT50 (hrs) as indicator of long-range air transport risk
4.5	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Calculated using the Atkinson method. Assumed 1.5E+06 OH/cm3, 12 hr. EU trigger for long-range transport is DT50 in air <2 days.	Below the level of concern for long-range air transport
Bio-concentration factor
	BCF (l kg−1)
380	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	Threshold for concern
CT50 (days)
Not available	-

Metabolite
Major/Minor fraction
Estimated maximum occurrence fraction
Notes
hydroxy quizalofop (Ref: CGA 294972)
Major fraction	0.157	Adama verified
dihydroxy quinoxaline (Ref: CGA 294970)
Major fraction	0.137	Adama verified
quizalofop (Ref: CGA 287422)
Major fraction	0.876	Adama verified

Known groundwater metabolites

Metabolite
EC SANCO/221/2000 relevancy
ADI (mg kg−1 bodyweight day−1)
WHO drinking water guidance value (μg L−1 day−1)
hydroxy quizalofop (Ref: CGA 294972)
Relevancy unknown	-	-
dihydroxy quinoxaline (Ref: CGA 294970)
Relevancy unknown	-	-
quizalofop (Ref: CGA 287422)
Relevancy unknown	-	-

Other known metabolites

None

Terrestrial ecotoxicology

Property
Value
Source; quality score; and other information
Interpretation
Mammals - Acute oral LD50 (mg kg−1)
1182	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Rat	Moderate
Mammals - Short term dietary NOEL
	(mg kg−1)
7.7	L2 L = Pesticide manuals and hard copy reference books / other sources 2 = Unverified data of unknown source Rat 2 yr	High
(ppm diet)
-	-
Mammals - Chronic 21d NOAEL (mg kg−1 bw d−1)
37.8	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Rat Reproductive NOAEL	Moderate
Birds - Acute LD50 (mg kg−1)
> 2000	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Anas platyrhynchos	Low
Birds - Short term dietary (LC50/LD50)
-	-	-
Birds - Chronic 21d NOEL (mg kg−1 bw d−1)
58	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Anas platyrhynchos NOEC	Moderate
Earthworms - Acute 14 day LC50 (mg kg−1 dw soil)
> 500	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Eisenia foetida corr	Moderate
Earthworms - Chronic NOEC, reproduction (mg kg−1 dw soil)
250	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Eisenia foetida corr	Low
Soil micro-organisms
Nitrogen mineralisation: No significant adverse effect Carbon mineralisation: No significant adverse effect	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Dose: 925 g ha−1 60 Day	-
Collembola
	Acute LC50 (mg kg−1)
-	-	-
Chronic NOEC (mg kg−1)
-	-	-
Non-target plants
	Vegetative vigour ER50 (g ha−1)
5.46	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Zea mays	-
Seedling emergence ER50 (g ha−1)
52.31	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Zea mays	-
Honeybees (Apis spp.)
	Contact acute LD50 (worst case from 24, 48 and 72 hour values - μg bee−1)
	> 100	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Apis mellifera	Low
	Oral acute LD50 (worst case from 24, 48 and 72 hour values - μg bee−1)
	> 100	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Apis mellifera	Low
Unknown mode acute LD50 (worst case from 24, 48 and 72 hour values - μg bee−1)
-	-	-
Chronic
-	-	-
Notes
-
Bumblebees (Bombus spp.)
	Contact acute LD50 (worst case from 24, 48 and 72 hour values - μg bee−1)
		-	-	-
	-
Oral acute LD50 (worst case from 24, 48 and 72 hour values - μg bee−1)
	-	-	-
-
Mason bees (Osmia spp.)
	Contact acute LD50 (worst case from 24, 48 and 72 hour values - μg bee−1)
-	-	-
Oral acute LD50 (worst case from 24, 48 and 72 hour values - μg bee−1)
-	-	-
Other bee species (1)
	Acute LD50 (worst case from 24, 48 and 72 hour values - μg insect−1)
-	-	-
Mode of exposure
-
Other bee species (2)
	Acute LD50 (worst case from 24, 48 and 72 hour values - μg insect−1)
-	-	-
Mode of exposure
-
Beneficial insects (Ladybirds)
-	-	-
Beneficial insects (Lacewings)
-	-	-
Beneficial insects (Parasitic wasps) as Mortality LR50 g ha−1, Std lab test
48.5	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Aphidius rhopalosiphi	Moderate
Beneficial insects (Predatory mites) as Mortality LR50 g ha−1, Std lab test
25.0	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Typhlodromus pyri	Moderate
Beneficial insects (Ground beetles)
-	-	-

Aquatic ecotoxicology

Property
Value
Source; quality score; and other information
Interpretation
Temperate Freshwater Fish - Acute 96 hour LC50 (mg l−1)
0.21	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Lepomis macrochirus	Moderate
Temperate Freshwater Fish - Chronic 21 day NOEC (mg l−1)
0.044	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Oncorhynchus mykiss	Moderate
Tropical Freshwater Fish - Acute 96 hour LC50 (mg l−1)
-	-	-
Temperate Freshwater Aquatic invertebrates - Acute 48 hour EC50 (mg l−1)
0.29	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Daphnia magna	Moderate
Temperate Freshwater Aquatic invertebrates - Chronic 21 day NOEC (mg l−1)
0.023	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Daphnia magna	Moderate
Tropical Freshwater Aquatic invertebrates - Acute 48 hour EC50 (mg l−1)
-	-	-
Aquatic crustaceans - Acute 96 hour LC50 (mg l−1)
-	-	-
Sediment dwelling organisms - Acute 96 hour LC50 (mg l−1)
-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l−1)
-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg−1)
-	-	-
Aquatic Plants (free-floating, fonds growth, fresh) - 7 day (mg l−1) (EC50, Static)
0.098	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Lemna gibba	Moderate
Aquatic plants (rooted, growth rate, fresh) - 14 day (mg l−1)
-	-	-
Algae - Acute (growth rate, fresh; mg l−1) (72 hr ErC50, Static)
0.069	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Raphidocelis subcapitata	Moderate
Algae - Chronic (growth rate, fresh; mg l−1)
-	-	-
Mesocosm study data
	NOEAEC mg l−1
-	-	-
NOEAEC mg l−1
-	-	-
Marine bivalves
-	-	-

General

Property
Value
Source; quality score; and other information
Interpretation
Threshold of Toxicological Concern (Cramer Class)
High (class III)	-	-
Mammals - Acute oral LD50 (mg kg−1)
1182	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Rat	Moderate
Mammals - Dermal LD50 (mg kg−1 body weight)
> 5000	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Rat (racemate)	-
Mammals - Inhalation LC50 (mg l−1)
5.8	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Rat 4 hr (nose only)	-
Other Mammal toxicity endpoints
-	-	-
ADI - Acceptable Daily Intake (mg kg−1 bw day−1)
0.009	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	-
ARfD - Acute Reference Dose (mg kg−1 bw day−1)
None allocated	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	-
AAOEL - Acute Acceptable Operator Exposure Level (mg kg−1 bw day−1)
-	-	-
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg−1 bw day−1)
0.01	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	-
Dermal penetration studies (%)
18-28	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes concentration dependent	-
Dangerous Substances Directive 76/464
-	-	-
Exposure Routes
	Public
Negligible risk to bystanders
Occupational
Operators require PPE
MRLs
	European
	EU MRL pesticide database
Great Britain
GB MRL Register
Notes
GB MRL expected to deviate from the EU MRL in mid-2023
Drinking Water Standards
-	-	-
Drinking Water MAC (μg l−1)
-	-	-
Mammalian dose elimination route and rate
-	-	-

Health issues

Specific human health issues (hazard-based)
Carcinogen Genotoxic Endocrine disruptor XNo, known not to cause a problem A3 A = Chromosome aberration (EFSA database) 3 = Negative ; B2 B = DNA damage/repair (EFSA database) 2 = Mixed/ambiguous results ; C3 C = Gene mutation (EFSA database) 3 = Negative ; D0 D = Genome mutation (EFSA database) 0 = No data ; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative No data found Reproduction / development effects Acetyl cholinesterase inhibitor Neurotoxicant ?Possibly, status not identified XNo, known not to cause a problem No data found Respiratory tract irritant Skin irritant Skin sensitiser No data found XNo, known not to cause a problem No data found Eye irritant Phototoxicant   ✓Yes, known to cause a problem No data found
General human health issues
Possible liver toxicant

Handling issues

Property
Value and interpretation
General
Not explosive or oxidising Combustiable IMDG Transport Hazard Class 9 Not expected to auto-ignite
CLP classification 2013
Health: H302, H312 Environment: H400, H410, H413
WHO Classification
Not listed (Not listed)
UN Number
UN3077
Waste disposal & packaging
Packaging Group III (minor danger)
Shelf-life, storage, stability and reactivity
Store at -20 DegC

Language
Name
English
quizalofop-P-ethyl
French
quizalofop-P-ethyl
German
Quizalofop-P-ethyl
Danish
quizalofop-P-ethyl
Italian
quizalofop-etile-isomero D
Spanish
quizalofop-P-etil
Greek
-
Polish
kwizalofop-P-etylowy
Swedish
-
Hungarian
quinzalofop-P-etil
Dutch
-
Norwegian
-

---