Isoproturon (Ref: HOE 16410)

---

SUMMARY Hazard alerts

The following Pesticide Hazard Tricolour (PHT) alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement. The alerts for Highly Hazardous Pesticides (HHPs) are based on applying the FAO/WHO (Type 1) and the PAN (Type II) criteria to PPDB data. Further details on the HHP indicators are given in the tables below. Neither the PHT nor the HHP hazard alerts take account of usage patterns or exposure, thus they do not represent risk.

PHT: Environmental fate	PHT: Ecotoxicity	PHT: Human health	Highly Hazardous Pesticide
Environmental fate Moderate alert: GUS: Transition state; Drainflow: Moderately mobile	Ecotoxicity Moderate alert: Birds acute ecotoxicity: Moderate; Fish acute ecotoxicity: Moderate; Fish chronic ecotoxicity: Moderate; Daphnia acute ecotoxicity: Moderate; Daphnia chronic ecotoxicity: Moderate	Human health High alert: Endocrine disruptor	Highly Hazardous Pesticide (HHP) Type II alert

Description
A herbicide for use, typically, in cereals to control annual grasses and many broadleaved weeds
Example pests controlled
Annual grass weeds; Broadleaved weeds
Example applications
Cereals including wheat, barley, rye; Rice-wheat cropping systems
Efficacy & activity
-

GB regulatory status

GB COPR regulatory status
Not approved
Date COPR inclusion expires
Expired
GB LERAP status
No UK approval for use as a plant protection agent

EC Regulation 1107/2009 (repealing 91/414)

EC Regulation 1107/2009 status
Not approved
Dossier rapporteur/co-rapporteur
Germany
Date EC 1107/2009 inclusion expires
Expired
EU Candidate for substitution (CfS)
Not applicable
Listed in EU database
Yes
Approved for use (✓) under EC 1107/2009 in the following EU Member States
ATAustria BEBelgium BGBulgaria CYCyprus CZCzech Republic DEGermany DKDenmark EEEstonia ELGreece                   ESSpain FIFinland FRFrance HRCroatia HUHungary IEIreland ITItaly LTLithuania LULuxembourg                   LVLatvia MTMalta NLNetherlands PLPoland PTPortugal RORomania SESweden SISlovenia SKSlovakia     ✓
Approved for use (✓) under EC 1107/2009 by Mutual Recognition of Authorisation and/or national regulations in the following EEA countries
ISIceland NONorway

Additional information

Also used in
-

Chemical structure

Isomerism
None
Chemical formula
C12H18N2O
Canonical SMILES
CC(C)C1=CC=C(C=C1)NC(=O)N(C)C
Isomeric SMILES
No data
International Chemical Identifier key (InChIKey)
PUIYMUZLKQOUOZ-UHFFFAOYSA-N
International Chemical Identifier (InChI)
InChI=1S/C12H18N2O/c1-9(2)10-5-7-11(8-6-10)13-12(15)14(3)4/h5-9H,1-4H3,(H,13,15)
2D structure diagram/image available?
Yes

Common Name	Relationship	Link
isoproturon	-

General status

Pesticide type
Herbicide; Other substance
Other bioactivity & uses
Biocide; Antifouling agent; Slimicide
Substance groups
Urea herbicide; Phenylurea herbicide
Minimum active substance purity
970 g kg−1
Known relevant impurities
EU dossier - None declared
Substance origin
Synthetic
Mode of action
Selective, systemic absorbed by roots and leaves. Inhibits photosynthesis (photosystem II).
CAS RN
34123-59-6
EC number
251-835-4
CIPAC number
336
US EPA chemical code
-
PubChem CID
36679
CLP index number
006-044-00-7
Molecular mass
206.28
PIN (Preferred Identification Name)
-
IUPAC name
3-(4-isopropylphenyl)-1,1-dimethylurea
CAS name
N,N-dimethyl-N'-(4-(1-methylethyl)phenyl)urea
Global Governance status: Listed (✓) under
UK Poisons List Order 1972 Rotterdam Convention Montreal Protocol XNo The Poisons List Order 1972 XNo Rotterdam Convention XNo Montreal Protocol Stockholm Convention OSPAR EU Water Framework Directive XNo Stockholm Convention XNo OSPAR ✓Yes EU Water Framework Directive
Relevant Environmental Water Quality Standards
EU Directive 2008/105/EC EQS surface waters: annual average 0.3 μg l−1; max measured 1.0 μg l−1 UK Environment Agency non-statutory standard for the protection of aquatic life in fresh surface water and saltwater: 2 μg l−1 as annual average, 20 μg l−1 as max acceptable conc. Non-statutory WHO drinking water guideline 0.009 mg l−1
Forever chemical
-
Highly Hazardous Pesticide (HHP)
	Type I
-
Type II
Yes [ R02 Rule 2: Pesticide active ingredients that meet the criteria of carcinogenicity Categories 1A and 1B of the Globally Harmonized System on Classification and Labelling of Chemicals (GHS) (those with a CLP classification of H350) ; R05 Rule 5: Pesticide active ingredients that are confirmed endocrine disruptors according to the World Health Organization (WHO) definition of an endocrine disruptor ; R09 Rule 9: Pesticide active ingredients that have demonstrated a high aquatic toxicity (where acute ecotoxicity for fish, invertebrates or algae =< 0.1 mg l−1) ]
Other status information
Potential groundwater contaminant
Herbicide Resistance Class (HRAC MoA class)
C2
Herbicide Resistance Class (WSSA MoA class)
7
Insecticide Resistance Class (IRAC MoA class)
Not applicable
Fungicide Resistance Class (FRAC MOA class)
Not applicable
Examples of recorded resistance
Alopecurus myosuroides, Phalaris minor
Physical state
Colourless crystals

Commercial

Property
Value
Availability status
Current
Introduction & key dates
1971, introduced
Example manufacturers & suppliers of products using this active now or historically
AgriGuard BASF Bayer CropScience DAPT Makhteshim-Agan Nufarm Rotan CropScience
Example products using this active
Alpha IPU 500 Alpha Isoproturon Ingot Koala Trump Javelin Javelin Gold Protugan Tolugan Extra
Formulation and application details
Often supplied as a soluble concentrate that is mixed with water and used as a spray; New low dose formulations being considered for UK registration.
Commercial production
Isoproturon is commercially produced through a chemical synthesis that centers on forming its phenylurea structure. The process typically begins with the reaction of 4-isopropylaniline (derived from cumene) with dimethylcarbamoyl chloride or a similar urea-forming reagent. This condensation yields 3-(4-isopropylphenyl)-1,1-dimethylurea, the active herbicidal compound.
Impact on climate of production and use
Precise life cycle emissions are unpublished but Audsley et al. (2009) reported that it takes 378 MJ of energy per kg produced. This is equivalent to approximately 26.1 kg CO2e. There will also be emissions associated with packaging, transport and application.

Property
Value
Source; quality score; and other information
Interpretation
Solubility - In water at 20 °C at pH 7 (mg l−1)
70.2	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	Moderate
Solubility - In organic solvents at 20 °C (mg l−1)
		100	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes n-Heptane	-
		2000	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Xylene	-
		30000	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Acetone	-
46000	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes 1,2-Dichloroethane	-
Melting point (°C)
157.3	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	-
Boiling point (°C)
-	-	-
Degradation point (°C)
-	-	-
Flashpoint (°C)
-	-	-
Octanol-water partition coefficient at pH 7, 20 °C
	P
3.16 X 1002	Calculated	-
Log P
2.5	A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 4 = Verified data at 25 °C	Low
Fat solubility of residues
	Solubility
-	-	-
Data type
-	-	-
Density (g ml−1)
1.17	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	-
Dissociation constant pKa) at 25 °C
		Not applicable	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	-
No dissociation
Vapour pressure at 20 °C (mPa)
5.50 X 10-03	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	Low volatility
Henry's law constant at 25 °C (Pa m3 mol−1)
1.46 X 10-05	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	Non-volatile
Volatilisation as max % of applied dose lost
	From plant surface
0.4	A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 4 = Verified data	Volatilisation is not considered critical for air pollution
From soil surface
0.25	A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 4 = Verified data	Volatilisation is not considered critical for air pollution
Maximum UV-vis absorption L mol−1 cm−1
207.8nm = 32512, 241.5nm = 1972, 295nm = 550	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	-
Surface tension (mN m−1)
-	-	-

Degradation

Property
Value
Source; quality score; and other information
Interpretation
General biodegradability
-
Soil degradation (days) (aerobic)
	DT50 (typical)
	12	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	Non-persistent
	DT50 (lab at 20 °C)
	12	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	Non-persistent
	DT50 (field)
	23	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	Non-persistent
DT90 (lab at 20 °C)
39.2	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	Moderately persistent
DT90 (field)
51	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	-
DT50 modelling endpoint
-	-	-
Note
EU dossier lab studies DT50 range 7.2-18.2 days, DT90 = 23.8-111.1 days, field studies DT50 range 12-33 days, DT90 range 34-68 days
Dissipation rate RL50 (days) on plant matrix
	Value
-	-	-
Note
-
Dissipation rate RL50 (days) on and in plant matrix
	Value
4.5	R4 R = Peer reviewed scientific publications 4 = Verified data	-
Note
Published literature RL50 range 1.5-7.5 days, wheat, whole plant, n=2
Aqueous photolysis DT50 (days) at pH 7
	Value
48	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	Stable
Note
-
Aqueous hydrolysis DT50 (days) at 20 °C and pH 7
	Value
1560	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	Very persistent
Note
pH sensitive: DT50 1210 days at pH 5, 540 days at pH 9, all at 25 °C
Water-sediment DT50 (days)
149	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	Slow
Water phase only DT50 (days)
40	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	Stable
Sediment phase only DT50 (days)
-	-	-
Air degradation
As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT50’. Where data is available, this can be found in the Fate Indices section below.
Decay in stored produce DT50
-

Soil adsorption and mobility

Property
Value
Source; quality score; and other information
Interpretation
Linear
	Kd (mL g−1)
	-	-	-
Koc (mL g−1)
-
Notes and range
-
Freundlich
	Kf (mL g−1)
	2.83	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	Moderately mobile
	Kfoc (mL g−1)
122
1/n
0.8
Notes and range
EU dossier Kf range 0.26-27.1 mL g−1, Kfoc range 36-241 mL g−1, 1/n range 0.66-0.94, Soils = 21; Literature mean: kf = 3.0 mL g−1, Kfoc = 155 mL g−1, 1/n = 1.02, Soils = 33
pH sensitivity
No

Fate indices Known soil metabolites

Property
Value
Source; quality score; and other information
Interpretation
GUS leaching potential index
2.61	Calculated	Transition state
SCI-GROW groundwater index (μg l−1) for a 1 kg ha−1 or 1 l ha−1 application rate
	Value
1.45 X 10-01	Calculated	-
Note
-
Potential for particle bound transport index
Low	Calculated	-
Potential for loss via drain flow
Moderately mobile	Calculated	-
Photochemical oxidative DT50 (hrs) as indicator of long-range air transport risk
4.7	A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 4 = Verified data Calculated using the Atkinson method. Assumed 0.5E+06 OH/cm3, 24 hr. EU trigger for long-range transport is DT50 in air <2 days.	Below the level of concern for long-range air transport
Bio-concentration factor
	BCF (l kg−1)
177	R3 R = Peer reviewed scientific publications 3 = Unverified data of known source (Low risk LogP < 3 (A5))	Threshold for concern
CT50 (days)
Not available	-

Metabolite
Major/Minor fraction
Estimated maximum occurrence fraction
Notes
desmethylisoproturon
Major fraction	0.140	-

Known groundwater metabolites

None

Other known metabolites

None

Terrestrial ecotoxicology

Property
Value
Source; quality score; and other information
Interpretation
Mammals - Acute oral LD50 (mg kg−1)
1826	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Rat	Moderate
Mammals - Short term dietary NOEL
	(mg kg−1)
-	L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source Rat	-
(ppm diet)
400	-
Mammals - Chronic 21d NOAEL (mg kg−1 bw d−1)
10	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Rat Reproductive NOAEL	Moderate
Birds - Acute LD50 (mg kg−1)
1401	A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 4 = Verified data Unknown species	Moderate
Birds - Short term dietary (LC50/LD50)
> 5000 mg kg feed−1	A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 4 = Verified data Unknown species	-
Birds - Chronic 21d NOEL (mg kg−1 bw d−1)
-	-	-
Earthworms - Acute 14 day LC50 (mg kg−1 dw soil)
> 1000	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Eisenia foetida	Low
Earthworms - Chronic NOEC, reproduction (mg kg−1 dw soil)
-	-	-
Soil micro-organisms
Nitrogen mineralisation: No significant adverse effect Carbon mineralisation: No significant adverse effect	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Dose: 3.0 kg ha−1	-
Collembola
	Acute LC50 (mg kg−1)
-	-	-
Chronic NOEC (mg kg−1)
-	-	-
Non-target plants
	Vegetative vigour ER50 (g ha−1)
-	-	-
Seedling emergence ER50 (g ha−1)
-	-	-
Honeybees (Apis spp.)
	Contact acute LD50 (worst case from 24, 48 and 72 hour values - μg bee−1)
	200	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Apis mellifera	Low
	Oral acute LD50 (worst case from 24, 48 and 72 hour values - μg bee−1)
	195	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Apis mellifera	Low
Unknown mode acute LD50 (worst case from 24, 48 and 72 hour values - μg bee−1)
-	-	-
Chronic
-	-	-
Notes
-
Bumblebees (Bombus spp.)
	Contact acute LD50 (worst case from 24, 48 and 72 hour values - μg bee−1)
		-	-	-
	-
Oral acute LD50 (worst case from 24, 48 and 72 hour values - μg bee−1)
	-	-	-
-
Mason bees (Osmia spp.)
	Contact acute LD50 (worst case from 24, 48 and 72 hour values - μg bee−1)
-	-	-
Oral acute LD50 (worst case from 24, 48 and 72 hour values - μg bee−1)
-	-	-
Other bee species (1)
	Acute LD50 (worst case from 24, 48 and 72 hour values - μg insect−1)
-	-	-
Mode of exposure
-
Other bee species (2)
	Acute LD50 (worst case from 24, 48 and 72 hour values - μg insect−1)
-	-	-
Mode of exposure
-
Beneficial insects (Ladybirds)
-	-	-
Beneficial insects (Lacewings)
10% Mortality at dose 1.5 kg ha−1	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Chrysoperla carnea Larva	-
Beneficial insects (Parasitic wasps)
7.0% Mortality at dose 25 kg ha−1	A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 4 = Verified data Aphidius rhopalosiphi Adult	-
Beneficial insects (Predatory mites)
16.0% Mortality at dose 25 kg ha−1	A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 4 = Verified data Typhlodromus pyri Protonymph	-
Beneficial insects (Ground beetles)
-	-	-

Aquatic ecotoxicology

Property
Value
Source; quality score; and other information
Interpretation
Temperate Freshwater Fish - Acute 96 hour LC50 (mg l−1)
18	A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 4 = Verified data Unknown species	Moderate
Temperate Freshwater Fish - Chronic 21 day NOEC (mg l−1)
1	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Oncorhynchus mykiss	Moderate
Tropical Freshwater Fish - Acute 96 hour LC50 (mg l−1)
-	-	-
Temperate Freshwater Aquatic invertebrates - Acute 48 hour EC50 (mg l−1)
0.58	A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 4 = Verified data Unknown species	Moderate
Temperate Freshwater Aquatic invertebrates - Chronic 21 day NOEC (mg l−1)
0.12	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Daphnia magna	Moderate
Tropical Freshwater Aquatic invertebrates - Acute 48 hour EC50 (mg l−1)
-	-	-
Aquatic crustaceans - Acute 96 hour LC50 (mg l−1)
-	-	-
Sediment dwelling organisms - Acute 96 hour LC50 (mg l−1)
-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l−1)
-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg−1)
-	-	-
Aquatic Plants (free-floating, fonds growth, fresh) - 7 day (mg l−1) (EC50)
0.031	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Lemna minor	Moderate
Aquatic plants (rooted, growth rate, fresh) - 14 day (mg l−1) (ErC50)
0.53	F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data Myriophyllum spicatum	Moderate
Algae - Acute (growth rate, fresh; mg l−1) (EC50)
0.013	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Navicula pelliculosa	Moderate
Algae - Chronic (growth rate, fresh; mg l−1)
-	-	-
Mesocosm study data
	NOEAEC mg l−1
-	-	-
NOEAEC mg l−1
-	-	-
Marine bivalves – LOEC (mg l−1)
780	R4 R = Peer reviewed scientific publications 4 = Verified data Crassostrea gigas	-

General

Property
Value
Source; quality score; and other information
Interpretation
Threshold of Toxicological Concern (Cramer Class)
High (class III)	-	-
Mammals - Acute oral LD50 (mg kg−1)
1826	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Rat	Moderate
Mammals - Dermal LD50 (mg kg−1 body weight)
> 2000	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Rat	-
Mammals - Inhalation LC50 (mg l−1)
1.95	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Rat (aerosol)	-
Other Mammal toxicity endpoints
-	-	-
ADI - Acceptable Daily Intake (mg kg−1 bw day−1)
0.015	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	-
ARfD - Acute Reference Dose (mg kg−1 bw day−1)
None allocated	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	-
AAOEL - Acute Acceptable Operator Exposure Level (mg kg−1 bw day−1)
-	-	-
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg−1 bw day−1)
0.015	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	-
Dermal penetration studies (%)
17	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	-
Dangerous Substances Directive 76/464
-	-	-
Exposure Routes
	Public
No unacceptable risks to bystanders identified
Occupational
No unacceptable risks to operators or other workers identified
MRLs
	European
	EU MRL pesticide database
Great Britain
GB MRL Register
Notes
-
Drinking Water Standards
-	-	-
Drinking Water MAC (μg l−1)
-	-	-
Mammalian dose elimination route and rate
-	-	-

Health issues

Specific human health issues (hazard-based)
Carcinogen Genotoxic Endocrine disruptor ?Possibly, status not identified A2 A = Chromosome aberration (EFSA database) 2 = Mixed/ambiguous results ; B3 B = DNA damage/repair (EFSA database) 3 = Negative ; C3 C = Gene mutation (EFSA database) 3 = Negative ; D2 D = Genome mutation (EFSA database) 2 = Mixed/ambiguous results ; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data ✓Yes, known to cause a problem Reproduction / development effects Acetyl cholinesterase inhibitor Neurotoxicant ?Possibly, status not identified XNo, known not to cause a problem XNo, known not to cause a problem Respiratory tract irritant Skin irritant Skin sensitiser ?Possibly, status not identified ✓Yes, known to cause a problem XNo, known not to cause a problem Eye irritant Phototoxicant   ✓Yes, known to cause a problem No data found
General human health issues
Endocrine issues - Pregnane X cellular receptor activation CLP data - suspected carcingen

Handling issues

Property
Value and interpretation
General
IMDG Transport Hazard Class 9 Not expected to auto-ignite; Not highly flammable
CLP classification 2013
Health: H351, H373 Environment: H400, H410
WHO Classification
II (Moderately hazardous)
UN Number
UN3077
Waste disposal & packaging
Packaging Group III (minor danger)
Shelf-life, storage, stability and reactivity
Chemically stable under standard ambient conditions

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