Improved Carbon-Carbon Linking by Controlled Copper Catalysis
Treatment of RO3SC6H4Me-4 with R1MgBr in THF over Li2CuCl4 at -78 Deg with slowly raising the temp. to room temp. gave, in good yields, the derivs. RR1 (R = e.g. Et, Ph, cyclohexyl, or octyl; R1 = Et, CMe3, Ph, cyclohexyl). [on SciFinder (R)]
1974
13
82
CAN 80:107560 22-3 Physical Organic Chemistry Inst. Chim. Org.,Univ. Lausanne,Lausanne,Switz. Journal 0044-8249 written in German. 7204-29-7 Role: RCT (Reactant), RACT (Reactant or reagent) (Grignard reaction of, with Bu bromide); 953-91-3 Role: RCT (Reactant), RACT (Reactant or reagent) (Grignard reaction of, with Et bromide); 2345-85-9 Role: RCT (Reactant), RACT (Reactant or reagent) (Grignard reaction of, with Et bromide, catalysts for); 109-65-9 Role: RCT (Reactant), RACT (Reactant or reagent) (Grignard reaction of, with crotyl acetate); 80-40-0; 640-60-8; 3386-35-4 Role: RCT (Reactant), RACT (Reactant or reagent) (Grignard reaction of, with org. bromide, catalysts for); 74-96-4; 108-85-0; 108-86-1; 507-19-7 Role: RCT (Reactant), RACT (Reactant or reagent) (Grignard reaction of, with org. tosylates); 36247-34-4 Role: RCT (Reactant), RACT (Reactant or reagent) (Grignard reaction of, with tert-butyl bromide); 100-41-4P Role: PREP (Preparation) (by Grignard reaction of Et tosylate with Ph bromide); 15489-27-7 Role: CAT (Catalyst use), USES (Uses) (catalysts, for Grignard reaction of org. bromides with tosylates); 124-18-5P; 827-52-1P; 1678-91-7P; 13389-42-9P; 17302-37-3P; 33933-78-7P; 36685-02-6P; 49585-17-3P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of)
REVIEWED
EPFL