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Frowns is a chemoinformatics toolkit geared toward rapid development of chemistry related algorithms. It is written in almost 100% Python with a small portion written in C++.

Frowns is loosely based on the PyDaylight API that Andrew Dalke wrote to wrap the daylight C API. In some cases programs written using PyDaylight will also work under Frowns with a few minor changes. A good overview of PyDaylight is available at here.

A good place to look at what Smarts and Smiles are is at the daylight web site located at http://www.daylight.com/

• Smiles parser
• Smarts substructure searching
• SD file parser with SD field manipulations
• Depiction for SD files with coordinates
• Molecule Fingerprint generation
• Several forms of Ring Detection available
• Simple aromaticity perception
• Everything's a graph (i.e. can form canonical strings from incomplete pieces of a molecule)
  
• Full source code
• Really bad depiction of arbitray molecules! (requires AT&T's GraphViz)