ENZYME entry: EC 2.3.1.180

PURL: https://purl.expasy.org/enzyme/EC/2.3.1.180

Q669L1, FABH_YERPS Q9HU15, FABY_PSEAE

Accepted Name
beta-ketoacyl-[acyl-carrier-protein] synthase III
Alternative Name(s)
3-ketoacyl-acyl carrier protein synthase III
3-oxoacyl:ACP synthase III
beta-ketoacyl (acyl carrier protein) synthase III
beta-ketoacyl-ACP synthase III
beta-ketoacyl-acyl carrier protein synthase III
KASIII
KAS III
Reaction catalysed
malonyl-[ACP] + acetyl-CoA + H(+) = 3-oxobutanoyl-[ACP] + CO2 + CoA
Comment(s)
The enzyme is responsible for initiating straight-chain fatty acid biosynthesis by the dissociated (or type II) fatty-acid biosynthesis system that occurs in plants and bacteria. In contrast to EC 2.3.1.41 and EC 2.3.1.179, this enzyme specifically uses short-chain acyl-CoA thioesters (preferably acetyl-CoA) rather than acyl-[acp] as its substrate. The enzyme can also catalyze the reaction of EC 2.3.1.38, but to a much lesser extent. The enzymes from some organisms (e.g. the Gram-positive bacterium Streptococcus pneumoniae) can accept branched-chain acyl-CoAs in addition to acetyl-CoA (cf. EC 2.3.1.300).
Cross-references
BRENDA	2.3.1.180
EC2PDB	2.3.1.180
ExplorEnz	2.3.1.180
KEGG Ligand Database for Enzyme Nomenclature	2.3.1.180
IUBMB Enzyme Nomenclature	2.3.1.180
MEDLINE	Find literature relating to 2.3.1.180
MetaCyc	2.3.1.180
Rhea expert-curated reactions	2.3.1.180
UniProtKB/Swiss-Prot	Q81JG0, FABH1_BACAN Q81GM0, FABH1_BACCR O34746, FABH1_BACSU Q8ABI8, FABH1_BACTN P49244, FABH1_CUPWR Q9RT23, FABH1_DEIRA Q9K8W9, FABH1_HALH5 Q88YZ4, FABH1_LACPL Q8CPT4, FABH1_STAES Q82BB8, FABH1_STRAW P72392, FABH1_STRCO Q9KQH5, FABH1_VIBCH Q87N20, FABH1_VIBPA Q8D8G6, FABH1_VIBVU Q7M7J9, FABH1_VIBVY Q81JF6, FABH2_BACAN Q81F42, FABH2_BACCR O07600, FABH2_BACSU Q8A137, FABH2_BACTN P49245, FABH2_CUPWR Q9RT22, FABH2_DEIRA Q9KET5, FABH2_HALH5 Q88WG8, FABH2_LACPL Q8CUB8, FABH2_STAES Q82M29, FABH2_STRAW Q9Z4Y5, FABH2_STRCO Q9KLJ3, FABH2_VIBCH Q87HJ2, FABH2_VIBPA Q8D719, FABH2_VIBVU Q7M7I3, FABH2_VIBVY O54151, FABH3_STRCO Q9ZBV4, FABH4_STRCO Q9JN82, FABH5_STRCO Q9PMZ6, FABHL_CAMJE B0CE67, FABH_ACAM1 A9NFF0, FABH_ACHLI A5FV65, FABH_ACICJ B9MDQ9, FABH_ACIET A1WAX8, FABH_ACISJ A3N232, FABH_ACTP2 A6VQV2, FABH_ACTSZ Q8UG62, FABH_AGRFC Q21XP4, FABH_ALBFT A8ERJ6, FABH_ALIB4 Q5E409, FABH_ALIF1 Q0A8R5, FABH_ALKEH B9JV87, FABH_ALLAM Q5PA98, FABH_ANAMM O67185, FABH_AQUAE P49243, FABH_ARATH Q5P0D6, FABH_AROAE B6YS41, FABH_AZOPC A1K5Y5, FABH_AZOSB A8FBX4, FABH_BACP2 A1USI9, FABH_BARBK Q6G3K4, FABH_BARHE Q6G000, FABH_BARQU A9IVB4, FABH_BART1 Q1LT37, FABH_BAUCH Q7VR18, FABH_BLOFL Q492Q4, FABH_BLOPB Q2KUK5, FABH_BORA1 Q7WD20, FABH_BORBR Q7W5I4, FABH_BORPA A9IIH4, FABH_BORPD Q7VW29, FABH_BORPE Q89K89, FABH_BRADU A5EKG5, FABH_BRASB A4YW84, FABH_BRASO B2S524, FABH_BRUA1 Q2YNB9, FABH_BRUA2 A6X1X8, FABH_BRUA4 Q57DX4, FABH_BRUAB A9MAF6, FABH_BRUC2 C0RIB3, FABH_BRUMB Q8YGH9, FABH_BRUME A5VPV8, FABH_BRUO2 B0CLA2, FABH_BRUSI Q8G1E0, FABH_BRUSU A0K5U6, FABH_BURCH Q39I86, FABH_BURL3 A3MM55, FABH_BURM7 A2S9Y2, FABH_BURM9 Q62LU2, FABH_BURMA A1V6D0, FABH_BURMS B1JYA0, FABH_BURO0 Q1BXV4, FABH_BURO1 A3NXM9, FABH_BURP0 Q3JQ65, FABH_BURP1 A3NBU2, FABH_BURP6 Q63S83, FABH_BURPS Q2SXU7, FABH_BURTA A4JCP8, FABH_BURVG Q8R9V7, FABH_CALS4 A4XJW0, FABH_CALS8 A7ZC01, FABH_CAMC1 A7H054, FABH_CAMC5 A0RMK8, FABH_CAMFF A7I3D6, FABH_CAMHC A8FKB7, FABH_CAMJ8 A7H541, FABH_CAMJD Q9PIH1, FABH_CAMJE A1VY47, FABH_CAMJJ Q5HWE3, FABH_CAMJR Q9A8I4, FABH_CAUVC A3PJ64, FABH_CERS1 Q3J365, FABH_CERS4 A4WTT9, FABH_CERS5 Q11J83, FABH_CHESB Q3AQ09, FABH_CHLCH Q820E6, FABH_CHLCV Q3B6K8, FABH_CHLL3 Q9PKF5, FABH_CHLMU A1BJA1, FABH_CHLPD A4SCL4, FABH_CHLPM Q9Z8P0, FABH_CHLPN Q3KMC3, FABH_CHLTA Q8KAP2, FABH_CHLTE O84242, FABH_CHLTR Q7NSK7, FABH_CHRVO A8AHY1, FABH_CITK8 Q97DA2, FABH_CLOAB A7FPM6, FABH_CLOB1 C3KWF7, FABH_CLOB6 A6LSC2, FABH_CLOB8 A5I7X8, FABH_CLOBH C1FNK7, FABH_CLOBJ B1IHN1, FABH_CLOBK A7GJJ9, FABH_CLOBL B1KU74, FABH_CLOBM Q18B40, FABH_CLOD6 B9DY04, FABH_CLOK1 A5N4E1, FABH_CLOK5 A0PXB6, FABH_CLONN Q0TRH0, FABH_CLOP1 Q8XLH3, FABH_CLOPE Q0STU9, FABH_CLOPS Q899P3, FABH_CLOTE B6J8E5, FABH_COXB1 B6J1I6, FABH_COXB2 A9KEA1, FABH_COXBN A9NBY3, FABH_COXBR Q820X0, FABH_COXBU A7MFQ4, FABH_CROS8 Q0K8L9, FABH_CUPNH Q46Z05, FABH_CUPPJ B3R213, FABH_CUPTR P0DW99, FABH_CUTAC C1D0N4, FABH_DEIDV Q1J198, FABH_DEIGD A9BNK6, FABH_DELAS B8FRS6, FABH_DESHD Q24U40, FABH_DESHY Q6AJF8, FABH_DESPS A5EXD7, FABH_DICNV A8LLT4, FABH_DINSH A7ZKJ4, FABH_ECO24 P0A6R2, FABH_ECO57 A7ZZ48, FABH_ECOHS A1A9Y5, FABH_ECOK1 Q0TIY3, FABH_ECOL5 P0A6R1, FABH_ECOL6 B1IUH4, FABH_ECOLC P0A6R0, FABH_ECOLI Q1RD66, FABH_ECOUT Q3YRP7, FABH_EHRCJ Q2GH17, FABH_EHRCR Q5FFP2, FABH_EHRRG Q5HAV9, FABH_EHRRW A4W9A5, FABH_ENT38 Q820T1, FABH_ENTFA Q2N925, FABH_ERYLH Q8RGX7, FABH_FUSNN Q5L1U1, FABH_GEOKA Q7NF35, FABH_GLOVI Q0BTE0, FABH_GRABC Q6B945, FABH_GRATL Q7U337, FABH_HAEDU Q4QP30, FABH_HAEI8 A5UFW1, FABH_HAEIG P43711, FABH_HAEIN Q17YQ2, FABH_HELAH P59813, FABH_HELHP B6JKD5, FABH_HELP2 B5Z9X2, FABH_HELPG Q1CUV9, FABH_HELPH Q9ZMN0, FABH_HELPJ B2US32, FABH_HELPS O24994, FABH_HELPY A4G6T2, FABH_HERAR Q0I0V6, FABH_HISS1 B0UUZ0, FABH_HISS2 Q0C312, FABH_HYPNA A6SXP9, FABH_JANMA Q28RG1, FABH_JANSC A6T7F1, FABH_KLEP7 B2GFZ7, FABH_KOCRD Q1IQ32, FABH_KORVE Q1GAG1, FABH_LACDA Q04AU8, FABH_LACDB A8YXS0, FABH_LACH4 Q9CHG0, FABH_LACLA A2RM32, FABH_LACLM Q030J8, FABH_LACLS C1DCE8, FABH_LARHH Q38XG4, FABH_LATSS Q03RV2, FABH_LEVBA A5VK78, FABH_LIMRD B2G7L1, FABH_LIMRJ Q929H1, FABH_LISIN C0LNR0, FABH_LISM4 Q71XG3, FABH_LISMF Q8Y573, FABH_LISMO A0AKV5, FABH_LISW6 A1U0E3, FABH_MARN8 Q606L3, FABH_METCA B0JXE2, FABH_MICAN B1MKD7, FABH_MYCA9 B2A2M5, FABH_NATTJ Q5F4X5, FABH_NEIG1 B4RJI1, FABH_NEIG2 A9M142, FABH_NEIM0 Q9JW56, FABH_NEIMA Q9JXR6, FABH_NEIMB A1KRY9, FABH_NEIMF Q2GDD8, FABH_NEOSM Q0AIS4, FABH_NITEC Q82U60, FABH_NITEU Q2YA46, FABH_NITMU Q72CS6, FABH_NITV2 A1VEK1, FABH_NITV4 B8DJG1, FABH_NITV9 Q8Z062, FABH_NOSS1 Q2G5S1, FABH_NOVAD Q8ERU6, FABH_OCEIH Q04DM7, FABH_OENOB Q30YM1, FABH_OLEA2 A1TLD7, FABH_PARC0 A6LEP7, FABH_PARD8 A1B364, FABH_PARDP Q2W4R7, FABH_PARM1 B2JFI9, FABH_PARP8 Q9CJS8, FABH_PASMU Q6D690, FABH_PECAS C0QPF4, FABH_PERMH Q7N384, FABH_PHOLL A6KXK3, FABH_PHOV8 A4SVV4, FABH_POLAQ A1VRU7, FABH_POLNA B1XTK6, FABH_POLNS Q126I8, FABH_POLSJ B2RH63, FABH_PORG3 Q7MAV3, FABH_PORGI P51196, FABH_PORPU P31176, FABH_PORUM A3PAK3, FABH_PROM0 A8G2E1, FABH_PROM2 A2BUB2, FABH_PROM5 Q31D45, FABH_PROM9 Q7VE55, FABH_PROMA Q7V4F6, FABH_PROMM Q7V3E0, FABH_PROMP Q46HN8, FABH_PROMT Q15TZ6, FABH_PSEA6 B7V4R0, FABH_PSEA8 Q02QG7, FABH_PSEAB Q9HYR2, FABH_PSEAE Q3IBW0, FABH_PSET1 A1STW1, FABH_PSYIN Q1XDU1, FABH_PYRYE Q8Y0J4, FABH_RALN1 B2U968, FABH_RALPJ Q1MIS6, FABH_RHIJ3 Q982Z8, FABH_RHILO Q92QT4, FABH_RHIME B9JCY9, FABH_RHIR8 A5VC86, FABH_RHIWR P59814, FABH_RHOBA P30790, FABH_RHOCA B6IMR5, FABH_RHOCS Q2RTS8, FABH_RHORT A8GPW1, FABH_RICAH A8GY06, FABH_RICB8 Q1RKA5, FABH_RICBR A8EZX3, FABH_RICCK Q92GC1, FABH_RICCN Q4UK49, FABH_RICFE A8F2R3, FABH_RICM5 Q9ZCH1, FABH_RICPR B0BV80, FABH_RICRO A8GTP2, FABH_RICRS Q68VX7, FABH_RICTY A7NK75, FABH_ROSCS Q164C9, FABH_ROSDO A5UWI7, FABH_ROSS1 Q1AW87, FABH_RUBXD Q5LQJ5, FABH_RUEPO Q1GI69, FABH_RUEST A9MGC9, FABH_SALAR Q57QG4, FABH_SALCH Q5PGU1, FABH_SALPA A9N5L3, FABH_SALPB Q8Z7J6, FABH_SALTI O85139, FABH_SALTY A8GD17, FABH_SERP5 Q8EDH1, FABH_SHEON Q31ZE6, FABH_SHIBS Q32EV1, FABH_SHIDS Q0T5U5, FABH_SHIF8 Q83RS8, FABH_SHIFL Q3Z326, FABH_SHISS A6U7Q5, FABH_SINMW Q2NU42, FABH_SODGM Q01QV9, FABH_SOLUE Q1GT90, FABH_SPHAL Q07510, FABH_SPIOL A7X0K2, FABH_STAA1 A6U089, FABH_STAA2 Q2FI93, FABH_STAA3 Q2FZS0, FABH_STAA8 A5IRG0, FABH_STAA9 Q2YWV3, FABH_STAAB Q5HHA2, FABH_STAAC A6QFJ3, FABH_STAAE P68795, FABH_STAAM P99159, FABH_STAAN Q6GIA4, FABH_STAAR Q6GAU3, FABH_STAAS A8Z088, FABH_STAAT Q8NXE2, FABH_STAAW Q5HQI2, FABH_STAEQ Q4L4Z3, FABH_STAHJ Q49WB6, FABH_STAS1 Q3K338, FABH_STRA1 P64112, FABH_STRA3 P64113, FABH_STRA5 C0M7U3, FABH_STRE4 B4U1B3, FABH_STREM Q54206, FABH_STRGA A8AYW5, FABH_STRGC Q9F6D4, FABH_STRLI Q8DSN2, FABH_STRMU Q99YD2, FABH_STRP1 Q04M58, FABH_STRP2 P0DB00, FABH_STRP3 B5E7F8, FABH_STRP4 Q5XAE0, FABH_STRP6 C1C5F4, FABH_STRP7 P64115, FABH_STRP8 Q1JA87, FABH_STRPB Q1JKE0, FABH_STRPC Q1JFD2, FABH_STRPD Q1J582, FABH_STRPF A2RCX0, FABH_STRPG B1I9L1, FABH_STRPI B8ZLI3, FABH_STRPJ Q48RR7, FABH_STRPM P0A3C5, FABH_STRPN P0DB01, FABH_STRPQ B2ILW2, FABH_STRPS B5XHY5, FABH_STRPZ P0A3C6, FABH_STRR6 A4W3N0, FABH_STRS2 C0ME18, FABH_STRS7 A3CQ60, FABH_STRSV A4VXD4, FABH_STRSY Q5M184, FABH_STRT1 Q5M5S1, FABH_STRT2 Q03M55, FABH_STRTD B9DVE9, FABH_STRU0 C1CCI2, FABH_STRZJ C1CIR8, FABH_STRZP C1CPS7, FABH_STRZT Q30PN6, FABH_SULDN A6QBY0, FABH_SULNB Q67PG0, FABH_SYMTH Q31N84, FABH_SYNE7 Q5N5X5, FABH_SYNP6 A5GP11, FABH_SYNPW A5GQJ2, FABH_SYNR3 Q0AVV3, FABH_SYNWW P73951, FABH_SYNY3 Q8DKL4, FABH_THEVB Q3SIM4, FABH_THIDA B8GSX7, FABH_THISH Q114K0, FABH_TRIEI Q3M9J4, FABH_TRIV2 P64117, FABH_TROW8 P64116, FABH_TROWT C5CSE2, FABH_VARPS A1WMX5, FABH_VEREI A5CWU7, FABH_VESOH Q73GG9, FABH_WOLPM B3CML1, FABH_WOLPP Q5GS22, FABH_WOLTR Q8PNE8, FABH_XANAC Q4URQ0, FABH_XANC8 Q8PBV1, FABH_XANCP Q3BWI9, FABH_XANE5 Q2P7B9, FABH_XANOM Q9PCG4, FABH_XYLFA Q87CL7, FABH_XYLFT A1JN67, FABH_YERE8 A7FH25, FABH_YERP3 Q1C6M8, FABH_YERPA Q8ZFT7, FABH_YERPE Q1CI19, FABH_YERPN A4TLS3, FABH_YERPP

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-