ELM - instance TRG_NLS_MonoExtN_4 in sequence P13051 at position 15

ELM

The Eukaryotic Linear Motif resource for

Functional Sites in Proteins

o Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002587	P13051 UNG UNG_HUMAN	15	21	SFFSPSPARKRHAPSPEPAV	TP	---	Homo sapiens (Human)	313

o Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0663	confocal microscopy	in vivo/in vitro	Otterlei,1998	support	likely	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Otterlei,1998	support	likely	FeatureDetection

o Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000495:
ELM Switch SWTI000495
Alternative splicing removes the nuclear localisation signal (NLS) of Uracil-DNA glycosylase (UNG), abrogating binding to Importin subunit alpha-1 (KPNA1) and import into the nucleus. In Isoform UNG1 of Uracil-DNA glycosylase (UNG) the NLS present in Isoform UNG2 of Uracil-DNA glycosylase (UNG) is replaced with a mitochondrial localisation signal (MLS), promoting different localisations of the different protein isoforms.

o Pathways

KEGG: The sequence P13051 is implicated in the following 2 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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