ELM - instance MOD_PKB_1 in sequence P04049 at position 254

ELM

The Eukaryotic Linear Motif resource for

Functional Sites in Proteins

o Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002553	P04049 RAF1 RAF1_HUMAN	254	262	GSLSQRQRSTSTPNVHMVST	TP	---	Homo sapiens (Human)	648

o Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0424	protein kinase assay	in vitro	Wang,2008	support	likely	InteractionDetection
experimental	MI:0019	coimmunoprecipitation	in vivo/in vitro	Wang,2008	support	likely	InteractionDetection

o Interactions

Uniprot Id	Domain family	Domain Start	Domain End	Affinity Min/Max (µMol)	Notes
(P31749) AKT1_HUMAN	PF00069 (Pkinase) Protein kinase domain	150	408	[mitab] [xml]

o Pathways

KEGG: The sequence P04049 is implicated in the following 83 Pathways: (color codes: This sequence=red, interacting sequence=orange)

o Diseases

Sequence Variation VAR_037811 (Pos 260) has been implicated in Noonan Syndrome 5; Ns5 (O MIM:611553 ).
Sequence Variation VAR_037813 (Pos 261) has been implicated in Noonan Syndrome 5; Ns5 (O MIM:611553 ).
Sequence Variation VAR_037812 (Pos 261) has been implicated in Noonan Syndrome 5; Ns5 (O MIM:611553 ).
Sequence Variation VAR_037814 (Pos 261) has been implicated in Noonan Syndrome 5; Ns5 (O MIM:611553 ).
Sequence Variation VAR_037807 (Pos 256) has been implicated in Noonan Syndrome 5; Ns5 (O MIM:611553 ).
Sequence Variation VAR_037808 (Pos 257) has been implicated in Leopard Syndrome 2; Lprd2 (O MIM:611554 ).
Sequence Variation VAR_037809 (Pos 259) has been implicated in Noonan Syndrome 5; Ns5 (O MIM:611553 ).

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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