ELM - instance MOD_GSK3_1 in sequence P35222 at position 30

ELM

The Eukaryotic Linear Motif resource for

Functional Sites in Proteins

o Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002616	P35222 CTNNB1 CTNB1_HUMAN	30	37	HWQQQSYLDSGIHSGATTTA	TP	---	Homo sapiens (Human)	781

o Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0586	inhibitor	Liu,2002	support	certain
experimental	MI:0424	protein kinase assay	in vivo	Liu,2002	support	certain	InteractionDetection
experimental	MI:0424	protein kinase assay	in vitro	Su,2008	support	certain	InteractionDetection
experimental	MI:0424	protein kinase assay	in vitro	Hart,1999	support	certain	InteractionDetection

o Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000296:
ELM Switch SWTI000296
Phosphorylation of Catenin beta-1 (CTNNB1) at T41 generates a docking site for Glycogen synthase kinase-3 beta (GSK3B), which then phosphorylates S37, thereby generating a new docking site for GSK3B. Subsequent phosphorylation of S33 by GSK3B switches the specificity of CTNNB1 to the F-box/WD repeat-containing protein 1A (BTRC), which recruits CTNNB1 to the SCF ubiquitin ligase complex.

o Pathways

KEGG: The sequence P35222 is implicated in the following 30 Pathways: (color codes: This sequence=red, interacting sequence=orange)

o Diseases

Sequence Variation VAR_017624 (Pos 37) has been implicated in Medulloblastoma; Mdb (O MIM:155255 ).
Sequence Variation VAR_017625 (Pos 37) has been implicated in Ovarian Cancer (O MIM:167000 ).
Sequence Variation VAR_017626 (Pos 37) has been implicated in Pilomatrixoma (O MIM:132600 ).
Sequence Variation VAR_017620 (Pos 34) has been implicated in Pilomatrixoma (O MIM:132600 ).
Sequence Variation VAR_017615 (Pos 32) has been implicated in Pilomatrixoma (O MIM:132600 ).
Sequence Variation VAR_017617 (Pos 33) has been implicated in Medulloblastoma; Mdb (O MIM:155255 ).
Sequence Variation VAR_017616 (Pos 32) has been implicated in Pilomatrixoma (O MIM:132600 ).
Sequence Variation VAR_017619 (Pos 33) has been implicated in Colorectal Cancer; Crc (O MIM:114500 ).

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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