ELM - instance DEG_SCF_TRCP1_1 in sequence Q9UKT4 at position 144

ELM

The Eukaryotic Linear Motif resource for

Functional Sites in Proteins

o Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI001311	Q9UKT4 FBXO5 FBX5_HUMAN	144	149	ETSRLYEDSGYSSFSLQSGL	TP	---	Homo sapiens (Human)	447

o Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0424	protein kinase assay	in vitro	Guardavaccaro,2003	support	likely	InteractionDetection
experimental	MI:0788	knock out	in vivo	Guardavaccaro,2003	support	likely
experimental	MI:0017	classical fluorescence spectroscopy	in vitro	Guardavaccaro,2003	support	likely	InteractionDetection

o Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000169:
ELM Switch SWTI000169
Dual phosphorylation of S145 and S149 in the TrCP1-binding motif of F-box only protein 5 (FBXO5) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.

o Pathways

KEGG: The sequence Q9UKT4 is implicated in the following 1 Pathway: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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