ELM - instance DEG_SCF_TRCP1_1 in sequence P03230 at position 210

ELM

The Eukaryotic Linear Motif resource for

Functional Sites in Proteins

o Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI001316	P03230 LMP1 LMP1_EBVB9	210	215	HPQQATDDSGHESDSNSNEG	TP	---	Human herpesvirus 4 (strain B95-8) (Epstein-Barr virus (strain B95-8))	386

o Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0019	coimmunoprecipitation	in vivo/in vitro	Tang,2003	support	certain	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Tang,2003	support	certain	FeatureDetection

o Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000158:
ELM Switch SWTI000158
Dual phosphorylation of S211 and S215 in the TrCP1-binding motif of Latent membrane protein 1 (LMP1) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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