Effect of Methimazole-induced Hypothyroidism on Adrenal and Gonadal Functions in Male Japanese Quail (Coturnix japonica)

Qiang WENG; Erina SAITA; Gen WATANABE; Shinji TAKAHASHI; Manila SEDQYAR; Akira K. SUZUKI; Shinji TANEDA; Kazuyoshi TAYA

doi:10.1262/jrd.19081

Journal of Reproduction and Development

Online ISSN : 1348-4400
Print ISSN : 0916-8818
ISSN-L : 0916-8818

Research Note

Effect of Methimazole-induced Hypothyroidism on Adrenal and Gonadal Functions in Male Japanese Quail (Coturnix japonica)

Qiang WENG, Erina SAITA, Gen WATANABE, Shinji TAKAHASHI, Manila SEDQYAR, Akira K. SUZUKI, Shinji TANEDA, Kazuyoshi TAYA

Author information

Qiang WENG
College of Biological Science and Technology, Beijing Forestry University
Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology
Erina SAITA
Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology
Department of Basic Veteninary Science, United Graduate School of Veterinary Sciences, Gifu University
Gen WATANABE
Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology
Department of Basic Veteninary Science, United Graduate School of Veterinary Sciences, Gifu University
Shinji TAKAHASHI
Ecological Effect Research Team, Dioxin and Environmental Endocrine Disrupter Research Project
Manila SEDQYAR
Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology
Department of Basic Veteninary Science, United Graduate School of Veterinary Sciences, Gifu University
Akira K. SUZUKI
Environmental Newtoxicology Section Research Center for Environmental Risk, National Institute for Environmental Studies
Shinji TANEDA
Environmental Newtoxicology Section Research Center for Environmental Risk, National Institute for Environmental Studies
Kazuyoshi TAYA
Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology
Department of Basic Veteninary Science, United Graduate School of Veterinary Sciences, Gifu University

Corresponding author

ORCID

Keywords: Adrenal, Gonad, Hypothyroidism, Japanese quail (Coturnix japonica), Methimazole

JOURNAL FREE ACCESS

2007 Volume 53 Issue 6 Pages 1335-1341

DOI https://doi.org/10.1262/jrd.19081

View "Advance Publication" version (October 23, 2007).

Details

Published: 2007 Received: - Available on J-STAGE: January 16, 2008 Accepted: September 04, 2007 Advance online publication: October 23, 2007 Revised: -

Abstract

To investigate the effect of hypothyroidism on gonadal and adrenal functions in male Japanese quail (Coturnix japonica), hypothyroidism was induced in male adult Japanese quail by daily administration of 2-Mercapto-1-methylimidazole (methimazole) in their drinking water. Four weeks after methimazole treatment, the Japanese quail were scarificed, and the plasma concentrations of free triiodothyronine (FT3), free thyroxine (FT4), total T3 (TT3), total T4 (TT4), corticosterone, testosterone, LH and immunoreactive (ir) inhibins were measured by radioimmunoassy, the testes and adrenal glands were removed and weighed and the thyroid glands and testes were fixed in 4% paraformaldehyde for histological observation. The results showed that the hypothyroidism induced by methimazole caused a significant decrease in body and testes weight; the plasma levels of FT3, FT4 and TT4 significantly decreased, and the hypothyroid quail possessed a greater number of small follicles and more follicular epithelial cells in the thyroid gland. In addition, hypothyroidism resulted in a significant decrease in the plasma concentrations of corticosterone, LH, testosterone and ir-inhibin. Furthermore, no spermatogenesis was found in the seminiferous tubules of the methimazole treatment groups. These results clearly demonstrate that hypothyroidism caused both gonadal and adrenal disturbances in the adult male Japanese quail.

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この記事はクリエイティブ・コモンズ [表示 - 非営利 - 改変禁止 4.0 国際]ライセンスの下に提供されています。
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja

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