Effects of 3-Methyl-4-Nitrophenol in Diesel Exhaust Particles on the Regulation of Reproductive Function in Immature Female Japanese Quail (Coturnix japonica)

ChunMei LI; Shinji TAKAHASHI; Shinji TANEDA; Chie FURUTA; Gen WATANABE; Akira K. SUZUKI; Kazuyoshi TAYA

doi:10.1262/jrd.18133

Journal of Reproduction and Development

Online ISSN : 1348-4400
Print ISSN : 0916-8818
ISSN-L : 0916-8818

Research Note

Effects of 3-Methyl-4-Nitrophenol in Diesel Exhaust Particles on the Regulation of Reproductive Function in Immature Female Japanese Quail (Coturnix japonica)

ChunMei LI, Shinji TAKAHASHI, Shinji TANEDA, Chie FURUTA, Gen WATANABE, Akira K. SUZUKI, Kazuyoshi TAYA

Author information

ChunMei LI
Department of Basic Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu University
Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology
Shinji TAKAHASHI
Ecological Effect Research Team, Dioxin and Environmental Endocrine Disrupter Research Project, National Institute for Environmental Studies
Shinji TANEDA
Environmental Nanotoxicology Section, Research Center for Environmental Risk, National Institute for Environmental Studies
Chie FURUTA
Department of Basic Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu University
Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology
Gen WATANABE
Department of Basic Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu University
Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology
Akira K. SUZUKI
Environmental Nanotoxicology Section, Research Center for Environmental Risk, National Institute for Environmental Studies
Kazuyoshi TAYA
Department of Basic Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu University
Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology

Corresponding author

ORCID

Keywords: 3-Methyl-4-nitrophenol (PNMC), Diesel exhaust particle, Immature Japanese quail (coturnix japonica), Luteinizing hormone (LH), Oviduct

JOURNAL FREE ACCESS

2007 Volume 53 Issue 3 Pages 673-678

DOI https://doi.org/10.1262/jrd.18133

View "Advance Publication" version (December 29, 2006).

Details

Published: 2007 Received: - Available on J-STAGE: July 07, 2007 Accepted: December 04, 2006 Advance online publication: December 29, 2006 Revised: -

Abstract

In a previous study, we found that 3-methyl-4-nitrophenol (PNMC), a component of diesel exhaust particles and also a degradation product of the insecticide fenitrothion, exhibits reproductive toxicity in the adult male Japanese quail. The present study investigated the toxicity of PNMC in the female Japanese quail and its ability to influence reproduction in immature females. The quail (21-day-old) were injected intramuscularly (im) with PNMC at doses 0.1, 1 or 10 mg/kg body weight daily for 3 days. There was no significant difference in body growth between the PNMC-administered and control birds. However, the weights of the oviducts were significantly lower in the PNMC-treated birds at all doses. Furthermore, the plasma concentrations of luteinizing hormone (LH) and estradiol-17 β were significantly decreased with 1 and 10 mg/kg of PNMC. These findings suggest that PNMC might influence the hypothalamo-pituitary-gonadal axis with decreasing in secretion of GnRH, LH and ovarian steroid hormones and subsequently disturb growth of the reproductive organs of immature female quail. This study indicates that PNMC induces reproductive toxicity at the central level and disrupts reproductive function in the immature female quail.

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この記事はクリエイティブ・コモンズ [表示 - 非営利 - 改変禁止 4.0 国際]ライセンスの下に提供されています。
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja

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