Scientific article
OA PolicyEnglish
International trial of the Edmonton protocol for islet transplantation
ContributorsShapiro, A M James ; Ricordi, Camillo ; Hering, Bernhard J ; Auchincloss, Hugh ; Lindblad, Robert ; Robertson, R Paul ; Secchi, Antonio ; Brendel, Mathias D ; Berney, Thierry ; Brennan, Daniel C ; Cagliero, Enrico ; Alejandro, Rodolfo ; Ryan, Edmond A ; DiMercurio, Barbara ; Morel, Philippe ; Polonsky, Kenneth S ; Reems, Jo-Anna ; Bretzel, Reinhard G ; Bertuzzi, Federico ; Froud, Tatiana ; Kandaswamy, Raja ; Sutherland, David E R ; Eisenbarth, George ; Segal, Miriam ; Preiksaitis, Jutta ; Korbutt, Gregory S ; Barton, Franca B ; Viviano, Lisa ; Seyfert-Margolis, Vicki ; Bluestone, Jeffrey ; Lakey, Jonathan R T
Published inThe New England journal of medicine , vol. 355, no. 13, p. 1318-1330
Publication date2006
Abstract
Islet transplantation offers the potential to improve glycemic control in a subgroup of patients with type 1 diabetes mellitus who are disabled by refractory hypoglycemia. We conducted an international, multicenter trial to explore the feasibility and reproducibility of islet transplantation with the use of a single common protocol (the Edmonton protocol).
Keywords
- Adult
- Blood Glucose/metabolism
- C-Peptide/blood
- Diabetes Mellitus, Type 1/blood/therapy
- Feasibility Studies
- Follow-Up Studies
- Humans
- Hypoglycemic Agents/therapeutic use
- Immunosuppressive Agents/adverse effects/therapeutic use
- Infusions, Intravenous
- Insulin/secretion/therapeutic use
- Islets of Langerhans Transplantation/adverse effects/methods/standards
- Isoantibodies/blood
- Middle Aged
- Opportunistic Infections/epidemiology
- Portal Vein
- Reproducibility of Results
- Transplantation Conditioning/standards
Affiliation entities
Citation (ISO format)
SHAPIRO, A M James et al. International trial of the Edmonton protocol for islet transplantation. In: The New England journal of medicine, 2006, vol. 355, n° 13, p. 1318–1330. doi: 10.1056/NEJMoa061267
Main files (1)
Article (Published version)
Identifiers
- PID : unige:38893
- DOI : 10.1056/NEJMoa061267
- PMID : 17005949
Journal ISSN0028-4793
Technical informations
Creation22/07/2014 13:47:00
First validation22/07/2014 13:47:00
Update time14/03/2023 21:28:11
Status update14/03/2023 21:28:10
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