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Anti-alzheimer activity against Caenorhabditis elegans CL2006 assessed as reduction of amyloid beta plaque deposition at 1 to 50 uM measured after 4 days by ThioflavinS staining based fluorescence microscopy
Assay data:1 Tested
Summary PubMed Citation
Anti-alzheimer activity against Caenorhabditis elegans CL2006 assessed as reduction of amyloid beta plaque deposition at 1 uM measured after 4 days by ThioflavinS staining based fluorescence microscopy
Anti-alzheimer activity against Caenorhabditis elegans CL2006 assessed as reduction of amyloid beta plaque deposition at 10 uM measured after 4 days by ThioflavinS staining based fluorescence microscopy
Anti-alzheimer activity against Caenorhabditis elegans CL2006 assessed as reduction of amyloid beta plaque deposition at 50 uM measured after 4 days by ThioflavinS staining based fluorescence microscopy
Anti-alzheimer activity against Caenorhabditis elegans CL2006 assessed as increase in locomotor behaviour by measuring enhancement of number of thrashes at 1 to 50 uM
Assay data:2 Active, 2 Tested
Summary Compounds, Active PubMed Citation
Toxicity against wild type Caenorhabditis elegans N2 assessed as effect on food consumption at 0.01 to 100 uM measured after 6 days
Assay data:2 Tested
Inhibition of G9a in Caenorhabditis elegans CL2006 assessed as reduction in ratio of H3K9me2 to total H3 level at 50 uM by immunoblot analysis
Toxicity in wild type Caenorhabditis elegans N2 assessed as drug tolerance at 0.0001 to 50 uM
Toxicity in wild type Caenorhabditis elegans N2 assessed as effect on food consumption at 0.0001 to 50 uM measured daily for 7 days by food clearance assay
Toxicity in Caenorhabditis elegans AU37 assessed as survival at 4 ug/ml measured for 4 days
Toxicity in Caenorhabditis elegans AU37 assessed as survival at 20 ug/ml measured for 4 days
Synergistic anti-infective activity against Caenorhabditis elegans assessed as survival rate at 0.16 to 20 uM incubated for 24 hrs in presence of tobramycin relative to control
Synergistic anti-infective activity against Caenorhabditis elegans assessed as survival rate at 10 uM incubated for 24 hrs in presence of tobramycin relative to control
Anti-infective activity against Caenorhabditis elegans assessed as survival rate at MBC level incubated for 24 hrs relative to control
Inhibition of Caenorhabditis elegans GST-fused PRMT7 expressed in Escherichia coli at 250 uM using Caenorhabditis elegans GST-SFTB-2 (99 to 248 residues) peptide as substrate and human histone H2B as cosubstrate incubated under 15 degreeC in presence of 3H-SAM by SDS-PAGE based densitometric analysis relative to control
Assay data:3 Tested
Inhibition of Caenorhabditis elegans GST-fused PRMT7 expressed in Escherichia coli at 100 uM using Caenorhabditis elegans GST-SFTB-2 (99 to 248 residues) peptide as substrate and human histone H2B as cosubstrate incubated under 15 degreeC in presence of 3H-SAM by SDS-PAGE based densitometric analysis
Inhibition of Caenorhabditis elegans GST-fused PRMT9 expressed in Escherichia coli at 25 to 50 uM using Caenorhabditis elegans GST-SFTB2 (99 to 248 residues) peptide as substrate and human histone H2B as cosubstrate incubated under 25 degreeC in presence of 3H-SAM by SDS-PAGE based densitometric analysis relative to control
Inhibition of Caenorhabditis elegans GST-fused PRMT9 expressed in Escherichia coli at 100 uM using Caenorhabditis elegans GST-SFTB2 (99 to 248 residues) peptide as substrate and human histone H2B as cosubstrate incubated under 25 degreeC in presence of 3H-SAM by SDS-PAGE based densitometric analysis relative to control
Nematicidal activity against Caenorhabditis elegans
Neuroprotective activity against wild type Caenorhabditis elegans CL2122 assessed as motility changes by measuring worms bending frequency at 50 uM incubated for 36 hrs at 16 degreeC and 36 hrs at 23 degreeC
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