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PubChem BioAssay

Biological Activity

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Items: 1 to 20 of 154844

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Select item 20612661.

Assay of Inhibition of Escherichia coli RNA Polymerase from US Patent US20250115594: "ANTIBACTERIAL AGENTS: SOLUBLE SALTS AND AQUEOUS FORMULATIONS OF PYRONINS"

Source:: BindingDB

Protein Targets:: DNA-directed RNA polymerase subunit alpha; ...
Total:: 4

Assay data:7 Active, 7 Activity ≤ 1 μM, 7 Tested

AID:: 2061266

Summary Compounds, Active Compounds, activity ≤ 1 μM Related BioAssays by Depositor Related BioAssays by Target

Select item 20612652.

Assay of Inhibition of Staphylococcus aureus RNA Polymerase from US Patent US20250115594: "ANTIBACTERIAL AGENTS: SOLUBLE SALTS AND AQUEOUS FORMULATIONS OF PYRONINS"

Source:: BindingDB

Protein Targets:: DNA-directed RNA polymerase subunit beta; ...
Total:: 3

Assay data:6 Active, 1 Activity ≤ 1 nM, 6 Activity ≤ 1 μM, 6 Tested

AID:: 2061265

Summary Compounds, Active Compounds, activity ≤ 1 μM Related BioAssays by Depositor

Select item 20612643.

Assay of Inhibition of Mycobacterium tuberculosis RNA Polymerase from US Patent US20250115594: "ANTIBACTERIAL AGENTS: SOLUBLE SALTS AND AQUEOUS FORMULATIONS OF PYRONINS"

Source:: BindingDB

Protein Targets:: DNA-directed RNA polymerase subunit alpha; ...
Total:: 4

Assay data:4 Active, 4 Activity ≤ 1 μM, 6 Tested

AID:: 2061264

Summary Compounds, Active Compounds, activity ≤ 1 μM Related BioAssays by Depositor Related BioAssays by Target

Select item 20612094.

Measurement of Half Maximal Inhibitory Concentration (IC50) from US Patent US12263156: "Use of small molecule inhibitors of the BfrB:Bfd interaction in biofilms"

Source:: BindingDB

Protein Targets:: Pyrrole-2-carboxylic acid decarboxylase; ...
Total:: 1

Assay data:10 Active, 3 Activity ≤ 1 μM, 14 Tested

AID:: 2061209

Summary Compounds, Active Compounds, activity ≤ 1 μM

Select item 20611865.

Enzyme Inhibition Assay from US Patent US12258342: "Class of DNA gyrase and/or topoisomerase IV inhibitors with activity against gram-positive and gram-negative bacteria"

Source:: BindingDB

Protein Targets:: DNA gyrase subunit A; ...
Total:: 2

Assay data:44 Active, 42 Activity ≤ 1 μM, 45 Tested

AID:: 2061186

Summary Compounds, Active Compounds, activity ≤ 1 μM Related BioAssays by Target

Select item 20611826.

MraY Assay from US Patent US20250092081: "USE OF GLYCOSYLTRASNFERASE INHIBITORS FOR TREATING CANCER"

Source:: BindingDB

Protein Targets:: Phospho-N-acetylmuramoyl-pentapeptide-transferase; ...
Total:: 1

Assay data:5 Active, 3 Activity ≤ 1 μM, 6 Tested

AID:: 2061182

Summary Compounds, Active Compounds, activity ≤ 1 μM Related BioAssays by Depositor

Select item 20611817.

WecA Assay from US Patent US20250092081: "USE OF GLYCOSYLTRASNFERASE INHIBITORS FOR TREATING CANCER"

Source:: BindingDB

Protein Targets:: Decaprenyl-phosphate N-acetylglucosaminephosphotransferase; ...
Total:: 1

Assay data:4 Active, 3 Activity ≤ 1 μM, 6 Tested

AID:: 2061181

Summary Compounds, Active Compounds, activity ≤ 1 μM Related BioAssays by Depositor

Select item 20611488.

Fluorometric Assay from US Patent US12247013: "Indane derivatives for use in the treatment of bacterial infection"

Source:: BindingDB

Protein Targets:: Elastase; ...
Total:: 1

Assay data:49 Active, 35 Activity ≤ 1 μM, 49 Tested

AID:: 2061148

Summary Compounds, Active Compounds, activity ≤ 1 μM Related BioAssays by Target

Select item 20611479.

Enzyme Inhibition Assay from US Patent US12247004: "2-amino-N-(amino-oxo-aryl-lambda6-sulfanylidene)acetamide compounds and their therapeutic use"

Source:: BindingDB

Protein Targets:: Isoleucine--tRNA ligase; ...
Total:: 3

Assay data:187 Active, 99 Activity ≤ 1 μM, 213 Tested

AID:: 2061147

Summary Compounds, Active Compounds, activity ≤ 1 μM Related BioAssays by Target

Select item 206110810.

First Todd Group Plate of Idler compounds

Source:: Research group of Professor Matthew Todd, School of Pharmacy, University College London

Assay data:20 Active, 96 Tested

AID:: 2061108

Summary Compounds, Active

Select item 206104511.

Bioactivity Assay (pH=7.5) from US Patent US20250051321: "TRICYCLIC DERIVATIVE AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF"

Source:: BindingDB

Protein Targets:: Choline oxidase; ...
Total:: 2

Assay data:38 Active, 34 Activity ≤ 1 μM, 38 Tested

AID:: 2061045

Summary Compounds, Active Compounds, activity ≤ 1 μM Related BioAssays by Depositor

Select item 206104412.

Bioactivity Assay (pH=8.5) from US Patent US20250051321: "TRICYCLIC DERIVATIVE AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF"

Source:: BindingDB

Protein Targets:: Choline oxidase; ...
Total:: 2

Assay data:118 Active, 118 Activity ≤ 1 μM, 118 Tested

AID:: 2061044

Summary Compounds, Active Compounds, activity ≤ 1 μM Related BioAssays by Depositor

Select item 206084113.

Inhibitory Concentration (IC50) to UDP-2,3-diacylglucosamine hydrolase (LpxH) from US Patent US20250011300: "PIPERAZINYLSULFONYLARYL COMPOUNDS FOR TREATMENT OF BACTERIAL INFECTIONS"

Source:: BindingDB

Protein Targets:: UDP-2,3-diacylglucosamine hydrolase; ...
Total:: 1

Assay data:98 Active, 98 Activity ≤ 1 μM, 98 Tested

AID:: 2060841

Summary Compounds, Active Compounds, activity ≤ 1 μM

Select item 206078814.

Fluorescence Polarization (FP) Competition Binding Assay from US Patent US12173018: "Penicillin-binding protein inhibitors"

Source:: BindingDB

Protein Targets:: D-alanyl-D-alanine carboxypeptidase DacB; ...
Total:: 5

Assay data:207 Tested

AID:: 2060788

Summary Related BioAssays by Target

Select item 206077215.

Enzymatic Assay from US Patent US20240417387: "SULFONYLPIPERAZINYL COMPOUNDS FOR TREATMENT OF BACTERIAL INFECTIONS"

Source:: BindingDB

Protein Targets:: UDP-2,3-diacylglucosamine hydrolase; ...
Total:: 1

Assay data:63 Active, 63 Activity ≤ 1 μM, 63 Tested

AID:: 2060772

Summary Compounds, Active Compounds, activity ≤ 1 μM

Select item 206067616.

Inhibition of E. faecalis Decarboxylation Activity In Vitro from US Patent US12162902: "Decarboxylase inhibitors for treating Parkinson's disease"

Source:: BindingDB

Protein Targets:: L-tyrosine decarboxylase; ...
Total:: 1

Assay data:1 Active, 11 Tested

AID:: 2060676

Summary Compounds, Active Related BioAssays by Depositor

Select item 206067517.

Inhibition of Tyrosine Decarboxylase In Vitro from US Patent US12162902: "Decarboxylase inhibitors for treating Parkinson's disease"

Source:: BindingDB

Protein Targets:: L-tyrosine decarboxylase; ...
Total:: 1

Assay data:4 Active, 14 Tested

AID:: 2060675

Summary Compounds, Active Related BioAssays by Depositor

Select item 206063318.

LpxC Enzymatic Activity Assay from US Patent US20240382465: "AROMATIC ACETYLENE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF"

Source:: BindingDB

Protein Targets:: UDP-3-O-acyl-N-acetylglucosamine deacetylase; ...
Total:: 1

Assay data:93 Active, 93 Activity ≤ 1 μM, 93 Tested

AID:: 2060633

Summary Compounds, Active Compounds, activity ≤ 1 μM Related BioAssays by Target

Select item 180411319.

Enzyme Activity: Determination of IC50 from US Patent US10544130: "Metallo-beta-lactamase inhibitors"

Source:: BindingDB

Protein Targets:: Metallo-beta-lactamase type 2; ...
Total:: 1

Assay data:489 Active, 328 Activity ≤ 1 nM, 489 Activity ≤ 1 μM, 489 Tested

AID:: 1804113

Summary Compounds, Active Compounds, activity ≤ 1 μM Related BioAssays by Target

Select item 179858620.

Ligand Binding Assay from Article 10.1128/aac.00311-07: "Small-molecule scaffolds for CYP51 inhibitors identified by high-throughput screening and defined by X-ray crystallography."

Source:: BindingDB

Protein Targets:: Lanosterol 14-alpha demethylase; ...
Total:: 1

Assay data:7 Active, 13 Tested

AID:: 1798586

Summary Compounds, Active PubMed Citation

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Target

Proteins (1,952)
BioAssays with protein sequences specified as targets
RNAi Target, Active (1)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Chemical Probes (13)
BioAssays with compounds reported as validated chemical probes
Active Compounds (25,533)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (475)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 μM (8,580)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (37)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (20,304)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (90)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (154,842)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (2)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (471)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (153,938)
BioAssays extracted from the literature
NIH MLP (505)
BioAssays deposited by the NIH Molecular Libraries Program
Other (391)
BioAssays deposited by other experimentalists

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PubChem BioAssay

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