GEO Accession viewer

Status Public on Aug 23, 2016

Title Molecular Signatures Associated with ZIKV Exposure in Human Cortical Neural Progenitors

Organism Homo sapiens

Experiment type Expression profiling by high throughput sequencing

Summary Zika virus (ZIKV) infection causes microcephaly and has been linked to other brain abnormalities. How ZIKV impairs brain development and function remains elusive. Here we systematically profiled transcriptomes of human neural progenitor cells (hNPCs) exposed to Asian ZIKVC, African ZIKVM, and Dengue virus (DENV). DENV causes distinct gene expression changes; and ZIKV has a broader impact on the expression of gene involved in DNA replication and repair. While overall expression profiles are similar, ZIKVC, but not ZIKVM, induces upregulation of viral response genes. Our analyses reveal virus- and strain-specific molecular signatures associated with ZIKV infection. Further investigation of ZIKV-host interactions based our transcriptomic datasets may help to illuminate neural virulence determinants of ZIKV in patients.

Overall design Gene Expression Analyses of the cells infected with different flaviviruses

Contributor(s) Jin P

Citation(s) 27580721

Submission date Apr 19, 2016

Last update date May 15, 2019

Contact name Peng Jin

E-mail(s) peng.jin@emory.edu

Phone 4047273729

Organization name Emory University

Department Human Genetics

Lab Jin Lab

Street address 615 Michael St., Rm 325

City Atlanta

State/province Georgia

ZIP/Postal code 30322

Country USA

Platforms (3)

Samples (16)

Relations

BioProject PRJNA318898

SRA SRP073493

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Supplementary file Size Download File type/resource

GSE80434_RAW.tar 12.9 Mb (http) (custom) TAR (of FPKM_TRACKING)

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Raw data are available in SRA

Processed data provided as supplementary file