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Expression of class I major histocompatibility antigens switched off by highly oncogenic adenovirus 12 in transformed rat cells

Nature volume 305, pages 771–775 (1983)Cite this article

Abstract

Rat cells transformed by the highly oncogenic adenovirus 12 lack at least two cellular proteins which are present in cells transformed by the non-oncogenic adenovirus 5 and in untransformed cells. One protein has been identified as the heavy chain of the rat class I major histocompatibility complex. This finding may explain the difference in oncogenicity between adenoviral species.

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Author information

Authors and Affiliations

  1. Department of Medical Biochemistry, Sylvius Laboratories, State University, Wassenaarseweg 72, Leiden, 2333 AL, The Netherlands

    P. I. Schrier, R. Bernards, R. T. M. J. Vaessen, A. Houweling & A. J. van der Eb

Authors
  1. P. I. Schrier
  2. R. Bernards
  3. R. T. M. J. Vaessen
  4. A. Houweling
  5. A. J. van der Eb

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Schrier, P., Bernards, R., Vaessen, R. et al. Expression of class I major histocompatibility antigens switched off by highly oncogenic adenovirus 12 in transformed rat cells. Nature 305, 771–775 (1983). https://doi.org/10.1038/305771a0

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  • DOI: https://doi.org/10.1038/305771a0

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