Sysdiff is a nifty utility provided by Microsoft to take snapshots of a host so you can see what changes were made to it after installing an application for instance, whether they involve installing/changing files, or changes in the Registry.
/snap
/diff
/inf
/apply
Sysdiff will stop dead in its track if any file is open (error 32). Considering that a bunch of apps add stuff under eg. \WINDOWS,円 it's pretty useless to use sysdiff if you have to ignore this most important directory...