Chemistry
Chemistry
10th Edition
ISBN: 9781305957404
Author: Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher: Cengage Learning
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[画像:**Propose an Efficient Synthesis for the Following Transformation:** The chemical transformation involves converting a bromide-containing compound into a ketone. The transformation can be performed using some combination of the reagents listed below. Provide the necessary reagents in the correct order, as a string of letters (without spaces or punctuation, such as "EBF"). If there is more than one correct solution, provide just one answer. **Reagents List:** - **A.** PCC or DMP - **B.** 1) Epoxide; 2) \( \text{H}_3\text{O}^+ \) - **C.** [H\(^{+}\)], EtOH - **D.** \( \text{H}_3\text{O}^+ \), heat - **E.** Excess \( \text{CH}_3\text{NH}_2 \) - **F.** 1) \( \text{Et}_2\text{CuLi} \); 2) \( \text{H}_3\text{O}^+ \) - **G.** \( \text{Na}_2\text{Cr}_2\text{O}_7, \text{H}_2\text{SO}_4, \text{H}_2\text{O} \) - **H.** \( \text{NaCN} \) - **I.** 1) \( \text{CO}_2 \); 2) \( \text{H}_3\text{O}^+ \) - **J.** \( \text{SOCl}_2 \) - **K.** \( \text{Mg} \) - **L.** 1) \( \text{EtMgBr} \); 2) \( \text{H}_3\text{O}^+ \)]
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Transcribed Image Text:**Propose an Efficient Synthesis for the Following Transformation:** The chemical transformation involves converting a bromide-containing compound into a ketone. The transformation can be performed using some combination of the reagents listed below. Provide the necessary reagents in the correct order, as a string of letters (without spaces or punctuation, such as "EBF"). If there is more than one correct solution, provide just one answer. **Reagents List:** - **A.** PCC or DMP - **B.** 1) Epoxide; 2) \( \text{H}_3\text{O}^+ \) - **C.** [H\(^{+}\)], EtOH - **D.** \( \text{H}_3\text{O}^+ \), heat - **E.** Excess \( \text{CH}_3\text{NH}_2 \) - **F.** 1) \( \text{Et}_2\text{CuLi} \); 2) \( \text{H}_3\text{O}^+ \) - **G.** \( \text{Na}_2\text{Cr}_2\text{O}_7, \text{H}_2\text{SO}_4, \text{H}_2\text{O} \) - **H.** \( \text{NaCN} \) - **I.** 1) \( \text{CO}_2 \); 2) \( \text{H}_3\text{O}^+ \) - **J.** \( \text{SOCl}_2 \) - **K.** \( \text{Mg} \) - **L.** 1) \( \text{EtMgBr} \); 2) \( \text{H}_3\text{O}^+ \)
[画像:**Proposed Synthesis for Given Chemical Transformation:** **Transformation Description:** The task is to propose an efficient synthesis for converting a bromocyclohexane compound on the left to a carboxylic acid-ester compound on the right. **Reagents:** A. PCC or DMP B. NaCN C. [H+], EtOH D. H3O+, heat E. Excess CH3NH2 F. 1) Et2CuLi; 2) H3O+ G. Na2Cr2O7, H2SO4, H2O H. 1) LiAlH4; 2) H3O+ I. 1) CO2; 2) H3O+ J. NBS, heat K. Mg L. 1) EtMgBr; 2) H3O+ **Instructions:** To propose a synthesis pathway, select the correct sequence of reagent letters and write them as a string of letters without spaces or punctuation (e.g., "EBF"). If more than one solution is correct, provide only one. **Note:** The goal is to identify the reagents that would first convert the bromide group to a functional group capable of forming the ester, and then proceed to complete the synthesis to the final product shown.]
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Transcribed Image Text:**Proposed Synthesis for Given Chemical Transformation:** **Transformation Description:** The task is to propose an efficient synthesis for converting a bromocyclohexane compound on the left to a carboxylic acid-ester compound on the right. **Reagents:** A. PCC or DMP B. NaCN C. [H+], EtOH D. H3O+, heat E. Excess CH3NH2 F. 1) Et2CuLi; 2) H3O+ G. Na2Cr2O7, H2SO4, H2O H. 1) LiAlH4; 2) H3O+ I. 1) CO2; 2) H3O+ J. NBS, heat K. Mg L. 1) EtMgBr; 2) H3O+ **Instructions:** To propose a synthesis pathway, select the correct sequence of reagent letters and write them as a string of letters without spaces or punctuation (e.g., "EBF"). If more than one solution is correct, provide only one. **Note:** The goal is to identify the reagents that would first convert the bromide group to a functional group capable of forming the ester, and then proceed to complete the synthesis to the final product shown.
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