This collection explores the transformative impact of imaging informatics on dermatological practice, research, and patient care. This collection brings together cutting-edge research on digital dermatoscopy, automated skin lesion analysis, deep learning approaches for melanoma detection, standardization of dermoscopic imaging protocols, and the integration of imaging data with electronic health records. Contributors examine both the promising applications and practical challenges of implementing AI-driven diagnostic tools in clinical workflows, while addressing critical considerations around algorithm validation, regulatory approval, and healthcare equity.