Just today, my internet suddenly stopped working after booting up my PC. Pinging from CMD and browsing using Edge still worked; however, all other applications lost their access to the internet. After some troubleshooting, I narrowed the problem down to the HIGH-security settings of ConfigureDefender. After changing the settings to default, my internet started working correctly again.
Unfortunately, I cannot reproduce the exact steps to why my system's internet became unresponsive outside of running the HIGH-security preset. I was running the preset without issue for the better part of 2 months before the problem occurred, though.

The issue is probably not related to ConfigureDefender and is most likely a bug within Microsoft Defender, but I thought I'd share this nonetheless.

Used software:

Windows 10 Pro (x64), version 21H2 19044.1865

Antimalware Client Version: 4.18.2205.7
Engine Version: 1.1.19400.3
Antivirus Version: 1.371.1420.0
Anti-spyware Version: 1.371.1420.0

ConfigureDefender 3.0.1.1