TANGO2 mutations
Diseases

DEFINITION

TANGO2 (Transport and golgi organization 2 homolog) also known as chromosome 22 open reading frame 25 (C22orf25) is a protein that in humans is encoded by the TANGO2 gene.

The function of TANGO2 is not currently known.

THE GENE

CHEMICAL STRUCTURE AND IMAGES

When relevant for the function

• Primary structure
• Secondary structure
• Tertiary structure
  • PDB
• Quaternary structure

Protein Aminoacids Percentage
The Protein Aminoacids Percentage gives useful information on the local environment and the metabolic status of the cell (starvation, lack of essential AA, hypoxia)

Protein Aminoacids Percentage (Width 700 px)

SYNTHESIS AND TURNOVER

mRNA synthesis
protein synthesis

post-translational modifications
degradation

CELLULAR FUNCTIONS

cellular localization,
biological function

TANGO2

Recurrent Muscle Weakness with Rhabdomyolysis, Metabolic Crises, and Cardiac Arrhythmia Due to Bi-allelic TANGO2 Mutations. 2016 Houston
Recurrent Muscle Weakness with Rhabdomyolysis, Metabolic Crises, and Cardiac Arrhythmia Due to Bi-allelic TANGO2 Mutations. 2016, Dusseldorf

• Enzymes

• Cell signaling and Ligand transport
• Structural proteins

REGULATION

DIAGNOSTIC USE

file	user	date
TANGO2_CH1.gif	gp	03/04/2018
TANGO2_CH2.gif	gp	03/04/2018