PGC-1 alpha
Mitochondria

DEFINITION

A short protein description with the molecular wheight, isoforms, etc...
Use, when available, the link to Wikipedia (Es Trypsin)

External links not available on Wikipedia have to be added here

Wikigenes includes links to

• NCBI Gene
• NCBI SNP
• iHOP resource
• OMIM
• SNPedia
• UniProt
• Ensembl
• HGNC

CHEMICAL STRUCTURE AND IMAGES

When relevant for the function

• Primary structure
• Secondary structure
• Tertiary structure
  • PDB
• Quaternary structure

Protein Aminoacids Percentage
The Protein Aminoacids Percentage gives useful information on the local environment and the metabolic status of the cell (starvation, lack of essential AA, hypoxia)

Protein Aminoacids Percentage (Width 700 px)

SYNTHESIS AND TURNOVER

mRNA synthesis
protein synthesis
post-translational modifications
degradation

CELLULAR FUNCTIONS

cellular localization,
biological function

• Enzymes

• Cell signaling and Ligand transport
• Structural proteins

REGULATION

Pyruvate induces mitochondrial biogenesis by a PGC-1 alpha-independent mechanism.

Master regulator or readout: the wisdom of distributed control. 2010 Focus on Pyruvate suppresses PGC1{alpha} expression and substrate utilization despite increased respiratory chain content in C2C12 myotubes 2010

DIAGNOSTIC USE