digitalis
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digitalis
Digitalis
(religion, spiritualism, and occult)The dried leaf of the common foxglove (Digitalis purpurea). In 1775 William Witherington, a physician of Birmingham, England, learned of its effectiveness for heart conditions from an old Witch in Shropshire. It was one of several ingredients in her cures, and Witherington managed to isolate digitalis as the main active ingredient. He went on to make many contributions to medicine, and a monument was raised to him at Edgbaston Old Church. The carved decorations on that monument are of the foxglove.
Prior to Witherington's application of its use, country wise women used foxglove to treat many maladies, including epilepsy and tuberculosis. Nicholas Culpeper suggests it is "one of the best remedies for a scabby head," while Meyer warns it is "too dangerous for domestic use or self-medication." It certainly is extremely poisonous. Old folk names for it were Witch's Bells and Deadmen's Bells.
Three cardiac glucosides have been isolated from digitalis: digitoxin, gitoxin, and gitalin. No synthetic drugs can duplicate the action of the glycosides in foxglove in treating heart failure. Digitalis is recommended in congestive heart failure from any cause, although prolonged use leads to cumulation of the drug because of its slow excretion and destruction. Because of this, side effects can occur, including greater cardiac irregularities.
digitalis
[dij·ə′tal·əs]Digitalis
[dij·ə′tal·əs]Digitalis
a genus of plants of the family Scrophulariaceae. Plants of this genus are perennial or biennial grasses; rarely are they subshrubs or shrubs. The alternate, entire leaves are lanceolate or oblong. The yellow, purple, or yellow-brown flowers are irregular and often large; they are generally in dense terminal racemes. The perianth is five-parted; the bilabiate corolla is campanulate, thimble-shaped, or inflated. The fruit is a capsule.
There are approximately 35 species of Digitalis, distributed in Europe, western Asia and northern Africa; the Mediterranean region abounds in Digitalis. Of the six species found in the USSR, four grow only in the Caucasus and two grow in the Caucasus, the European USSR, and Western Siberia. They are found primarily in hardwood and mixed forests and in meadows, thickets, and pastures; they also grow on slopes.
All species of Digitalis are poisonous because they contain glycosides, primarily in their leaves. Some species are valuable medicinal herbs. These species include common foxglove (Digitalis purpurea) and yellow foxglove (D. grandiflora), which grow in the European USSR, the Caucasus, and the southern part of Western Siberia; Grecian foxglove (D. lanata), which grows in the Transcarpathian and Odessa oblasts; and such Caucasian species as rusty foxglove (D. ferruginea), D. Schischkinii, and D. ciliata.
The glycosides in the leaves regulate heart activity, increase urine elimination, and reduce edema. Medicinal preparations in the form of powders, tinctures, extracts, and neogalenic preparations (such as gitalen) are made from dried leaves, as are secondary glycosides (digitoxin, digoxin). Digitalis preparations are used under strict medical supervision for treating heart disease. Some species of Digitalis are ornamentals.
In the USSR, common foxglove is cultivated in Krasnodar Krai and Western Siberia; Grecian foxglove is raised in the Northern Caucasus and the Ukraine. Good yields are obtained on light chernozem soils. Foxglove should be planted on fields that have lain fallow or on which winter crops, annual hay grasses, and well-fertilized industrial and other row crops were previously cultivated. The seeds are generally sown 60 cm apart in the fall or spring; the sowing rate is 6–7 kg of seeds per hectare. Organic and inorganic fertilizers are applied during plowing. In the first and second years, the plants require nitrogen and phosphorous supplements.
Under optimum weather conditions and agricultural methods, the leaves may be gathered two or three times in the first year and one or two times in the second. The leaves of annual crops may be harvested first in July or August and later at intervals of one to 1 x/i months. The leaves of biennial foxglove may first be picked between shoot formation and flowering and later during massive flowering.
REFERENCES
Naperstianka. Moscow, 1954.Atlas lekarstvennykh rastenii SSSR. Moscow, 1962.
Lekarstvennye rasteniia SSSR kul’tiviruemye i dikorastushchie. Edited by A. A Khotin [et al.]. Moscow, 1967.
T. V. EGOROVA