digitalis


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digitalis

1. any Eurasian scrophulariaceous plant of the genus Digitalis, such as the foxglove, having bell-shaped flowers and a basal rosette of leaves
2.
a. a drug prepared from the dried leaves or seeds of the foxglove: a mixture of glycosides used medicinally to treat heart failure and some abnormal heart rhythms
b. any cardiac glycoside, whatever its origin
Collins Discovery Encyclopedia, 1st edition © HarperCollins Publishers 2005

Digitalis

(religion, spiritualism, and occult)

The dried leaf of the common foxglove (Digitalis purpurea). In 1775 William Witherington, a physician of Birmingham, England, learned of its effectiveness for heart conditions from an old Witch in Shropshire. It was one of several ingredients in her cures, and Witherington managed to isolate digitalis as the main active ingredient. He went on to make many contributions to medicine, and a monument was raised to him at Edgbaston Old Church. The carved decorations on that monument are of the foxglove.

Prior to Witherington's application of its use, country wise women used foxglove to treat many maladies, including epilepsy and tuberculosis. Nicholas Culpeper suggests it is "one of the best remedies for a scabby head," while Meyer warns it is "too dangerous for domestic use or self-medication." It certainly is extremely poisonous. Old folk names for it were Witch's Bells and Deadmen's Bells.

Three cardiac glucosides have been isolated from digitalis: digitoxin, gitoxin, and gitalin. No synthetic drugs can duplicate the action of the glycosides in foxglove in treating heart failure. Digitalis is recommended in congestive heart failure from any cause, although prolonged use leads to cumulation of the drug because of its slow excretion and destruction. Because of this, side effects can occur, including greater cardiac irregularities.

The Witch Book: The Encyclopedia of Witchcraft, Wicca, and Neo-paganism © 2002 Visible Ink Press®. All rights reserved.

digitalis

[dij·ə′tal·əs]
(pharmacology)
The dried leaf of the purple foxglove plant (Digitalis purpurea), containing digitoxin and gitoxin; constitutes a powerful cardiac stimulant and diuretic.

Digitalis

[dij·ə′tal·əs]
(botany)
A genus of herbs in the figwort family, Scrophulariaceae.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Digitalis

a genus of plants of the family Scrophulariaceae. Plants of this genus are perennial or biennial grasses; rarely are they subshrubs or shrubs. The alternate, entire leaves are lanceolate or oblong. The yellow, purple, or yellow-brown flowers are irregular and often large; they are generally in dense terminal racemes. The perianth is five-parted; the bilabiate corolla is campanulate, thimble-shaped, or inflated. The fruit is a capsule.

There are approximately 35 species of Digitalis, distributed in Europe, western Asia and northern Africa; the Mediterranean region abounds in Digitalis. Of the six species found in the USSR, four grow only in the Caucasus and two grow in the Caucasus, the European USSR, and Western Siberia. They are found primarily in hardwood and mixed forests and in meadows, thickets, and pastures; they also grow on slopes.

All species of Digitalis are poisonous because they contain glycosides, primarily in their leaves. Some species are valuable medicinal herbs. These species include common foxglove (Digitalis purpurea) and yellow foxglove (D. grandiflora), which grow in the European USSR, the Caucasus, and the southern part of Western Siberia; Grecian foxglove (D. lanata), which grows in the Transcarpathian and Odessa oblasts; and such Caucasian species as rusty foxglove (D. ferruginea), D. Schischkinii, and D. ciliata.

The glycosides in the leaves regulate heart activity, increase urine elimination, and reduce edema. Medicinal preparations in the form of powders, tinctures, extracts, and neogalenic preparations (such as gitalen) are made from dried leaves, as are secondary glycosides (digitoxin, digoxin). Digitalis preparations are used under strict medical supervision for treating heart disease. Some species of Digitalis are ornamentals.

In the USSR, common foxglove is cultivated in Krasnodar Krai and Western Siberia; Grecian foxglove is raised in the Northern Caucasus and the Ukraine. Good yields are obtained on light chernozem soils. Foxglove should be planted on fields that have lain fallow or on which winter crops, annual hay grasses, and well-fertilized industrial and other row crops were previously cultivated. The seeds are generally sown 60 cm apart in the fall or spring; the sowing rate is 6–7 kg of seeds per hectare. Organic and inorganic fertilizers are applied during plowing. In the first and second years, the plants require nitrogen and phosphorous supplements.

Under optimum weather conditions and agricultural methods, the leaves may be gathered two or three times in the first year and one or two times in the second. The leaves of annual crops may be harvested first in July or August and later at intervals of one to 1 x/i months. The leaves of biennial foxglove may first be picked between shoot formation and flowering and later during massive flowering.

REFERENCES

Naperstianka. Moscow, 1954.
Atlas lekarstvennykh rastenii SSSR. Moscow, 1962.
Lekarstvennye rasteniia SSSR kul’tiviruemye i dikorastushchie. Edited by A. A Khotin [et al.]. Moscow, 1967.

T. V. EGOROVA

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Strawberry foxglove (Digitalis x mertensis) is a cross between yellow and common foxgloves.
Entre ellas se destacan las pertenecientes al genero Digitalis, siendo Digitalis purpurea L.
The rounded sagging of the ST segments, with short QT intervals (0.26 s) and low T waves, is typical of digitalis effect, and digitalis excess is known to produce both conduction abnormalities and tachyarrhythmias in patients with cardiac disease.
However, the fetus also experiences adverse effects if the mother is experiencing digitalis toxicity (Frishman, Elkayam, & Aronow, 2012).
"In addition to test tube studies, low dose digoxin, the active ingredient of digitalis, was able to increase RGS2 levels in the heart and kidney," said senior study author and pharmacologist Rick Neubig, M.D., Ph.D., professor of pharmacology, associate professor of internal medicine, and co-director of the Center for Chemical Genomics at the University of Michigan.
Coverage includes pre-analytical variables, the pitfalls of immunoassays, tandem mass spectrometry, issues concerning pain management and herbal supplements, and therapeutic drug monitoring for a range of medications: anticonvulsants, digitalis, cardioactive drugs, antidepressants, immunosuppressants, anti-cancer drugs, vancomycin and aminoglycosides, antibiotics, antiretroviral drugs, non-narcotic analgesics, and anti-inflammatory drugs.
Upsher-Smith, a research pharmacist, began working on digitalis drug products to treat patients suffering from congestive heart failure.
Our plants, the hybrid Digitalis purpurea Camelot F1 Series, hearalded a breakthrough in breeding when introduced at the Chelsea Flower Show in 2004.
We owe the way we know the world to school-masters droning over the map of the day, blurbing stories of how empty space gets magically replaced with god's country, experts slurping fables into tables that don't chart our manifest destiny, newsreaders gleaming stars and dirty laundry in high deaf digitalis instead of clean scoops on the freedempire, streaming a banter of body counts that don't add up instead of countdowns to the last twilight.
The famous treatment for Dropsy was Digitalis, extracted from the Foxglove plant Digitalis Purpurea..

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