The company claims it uses a proprietary bonding and deactivation procedure that lowers
column bleed and reduces activity.
Bowers and Borts argue that the lack of improvement for the QIT when presented with an analyte present in a complex matrix arises because the width of the window for ion admittance to the trap allows matrix or
column bleed ions (or both) to enter with the analyte ions.
Thus, the ratio of the number of ions from
column bleed or matrix background to the number of ions of the compound of interest stays the same at the time that the total analytical signal is decreased.