aminopterin

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aminopterin

[‚a·mə′näp·tə·rən]

(pharmacology)

C₁₉H₂₀N₈O₅·2H₂O A yellow crystalline acid which is similar to folic acid and is used clinically as an antagonist of folic acid.

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Likewise dihydroreductase inhibitors, e.g., sulfasalazine, methotrexate, triamterene, and aminopterin, that block conversion of folate to its more active metabolites, are known to cause NTDs.

Prenatal screening tests facilitate risk assessment. (Cover Story)

These drugs include aminopterin sulfasalazine, pyrimethamine, triamterene, trimethoprim, and methotrexate (N.

Folic Acid Antagonists Raise the Risk of a Variety of Birth Defects

These drugs include aminopterin, sulfasalazine, pyrimethamine, triamterene, trimethoprim, and methotrexate, they reported (N.

Folic Acid Antagonists Raise The Risk of Birth Defects

During the 1940s childhood leukemias had a uniformly rapid fatal course over a short period of time, thus the designation of the term "acute."[5] In the late 1940s, Farber and colleagues[6] found that aminopterin (a folic acid antagonist) could induce temporary remissions in leukemia.

Providing Primary Care for Long-Term Survivors of Childhood Acute Lymphoblastic Leukemia

* aminopterin in Phase II in patients with persistent, recurrent or refractory endometrial carcinoma

ILEX Oncology acquires Convergence

Here's why: n A drug that prevents the body from using folic acid (aminopterin) causes NTDS in mice, cats, and rats.

Can vitamins prevent birth defects?

Hybridomas were selected in hypoxanthine aminopterin thymidine (HAT) medium.

Development and characterization of a novel anti-idiotypic monoclonal antibody to growth hormone, which can mimic physiological functions of growth hormone in primary porcine hepatocytes

Good examples of vitamin antagonists include isonicotinic acid hydrazide (antagonist of pyridoxine), aminopterin (folate antagonist), dicumarol (vitamin K antagonist), and avidin (interferes with biotin absorption).

Observations on multivitamins

wheat gluten contaminated with aminopterin, a toxin used in some countries as rat poison.

Hardwick cat, 9, succumbs after new `treat' in her diet

The federal government prohibits using aminopterin for killing rodents in the United States.

Tainted pet food sickens 7 local animals

* In utero exposure to aminopterin, an antagonist of folic acid, has been associated with anencephaly, meningocele, hydrocephalus, and cleft lip and palate (Thiersch 1952; Warkany et al.

Children's health and the environment: public health issues and challenges for risk assessment