The molecules involved in the second phase were mainly separated into two groups, that is, complete
mitogens and auxiliary
mitogens [20] (Table 1).
Mitogen Induced Proliferation and IFN-[gamma] Production.
Mitogen induced upregulation of hepatitis C virus expression in human lymphoid cells.
We used phytohemagglutinin P (PHA) and concanavalin A (ConA) as T-lymphocyte
mitogens, and lipopolysaccharide (LPS) and phorbol 12,13-dibutyrate (PDB) as B-lymphocyte
mitogens.
Reduced lymphocyte responses to
mitogens in natural and experimental trichomoniasis.
The cells were incubated for 96h with both VA-E at 0, 10, 100 and 1000 [micro]g/ml, interleukin-6 at 1000 U/ml, and pokeweed
mitogen and phytohaemagglutinine at 2.5 [micro]g/ml.
As would be expected in a normal population, the results of the
mitogen stimulation assays with the three different
mitogens were highly correlated with one another: (PHA/CON-A, r = 0.73 p = 0.0001, PHA/PWM logged to reduce skewness, r = 0.56 p = 0.0001, CON-A/PWM logged, r = 0.69 p = 0.0001.
The murine splenocytes were used to assess lymphocyte proliferation response after
mitogen stimulating for 20h.
A diet high in flaxseed (40% of the diet, w/w) significantly decreased
mitogen stimulated splenocyte proliferation in pregnant and F1 generation rats; however, defatted flaxseed meal or a lower concentration of flaxseed (20% of the diet, w/w) did not change the lymphocyte proliferation?
The suppressive effects on ovarian cyclicity are mimicked by a mitogenic agent purified from the ground corncob bedding material (corn
mitogen; CM), which stimulates the proliferation of estrogen receptor (ER)-positive (MCF-7 cells) and ER-negative (MDA-MD-231 cells) breast cancer cells.