ZAK
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Protein-coding gene in the species Homo sapiens
| MAP3K20 | |||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | MAP3K20 , AZK, MLK7, MLT, MLTK, MRK, mlklak, pk, ZAK, SFMMP, sterile alpha motif and leucine zipper containing kinase AZK, mitogen-activated protein kinase kinase kinase 20, MLTKalpha, MLTKbeta, CNM6 | ||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 609479; MGI: 2443258; HomoloGene: 32331; GeneCards: MAP3K20; OMA:MAP3K20 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||
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Sterile alpha motif and leucine zipper containing kinase AZK, also known as ZAK, is a human gene.[5]
This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[5] [6]
Interactions
[edit ]References
[edit ]- 1 2 3 GRCh38: Ensembl release 89: ENSG00000091436 – Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000004085 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- 1 2 "Entrez Gene: ZAK sterile alpha motif and leucine zipper containing kinase AZK".
- ↑ Liu TC, Huang CJ, Chu YC, Wei CC, Chou CC, Chou MY, et al. (11 August 2000). "Cloning and Expression of ZAK, a Mixed Lineage Kinase-like Protein Containing a Leucine-Zipper and a Sterile-Alpha Motif". Biochemical and Biophysical Research Communications. 274 (3): 811–816. Bibcode:2000BBRC..274..811L. doi:10.1006/bbrc.2000.3236. PMID 10924358.
- ↑ Yang JJ (Jan 2003). "A novel zinc finger protein, ZZaPK, interacts with ZAK and stimulates the ZAK-expressing cells re-entering the cell cycle". Biochemical and Biophysical Research Communications. 301 (1): 71–77. Bibcode:2003BBRC..301...71Y. doi:10.1016/S0006-291X(02)02980-7. ISSN 0006-291X. PMID 12535642.
Further reading
[edit ]- Lee JS, Lin YY, Wang TS, Liu JY, Lin WW, Yang JJ (28 February 2018). "Antitumorigenic Effects of ZAKβ, an Alternative Splicing Isoform of ZAK". The Chinese Journal of Physiology. 61 (1): 25–34. doi:10.4077/CJP.2018.BAG528. PMID 29374956.
- Liu TC, Huang CJ, Chu YC, Wei CC, Chou CC, Chou MY, etal. (2000). "Cloning and expression of ZAK, a mixed lineage kinase-like protein containing a leucine-zipper and a sterile-alpha motif". Biochemical and Biophysical Research Communications. 274 (3): 811–816. Bibcode:2000BBRC..274..811L. doi:10.1006/bbrc.2000.3236. PMID 10924358.
- Gotoh I, Adachi M, Nishida E (2001). "Identification and characterization of a novel MAP kinase kinase kinase, MLTK". Journal of Biological Chemistry. 276 (6): 4276–4286. doi:10.1074/jbc.M008595200 . PMID 11042189.
- Bloem LJ, Pickard TR, Acton S, Donoghue M, Beavis RC, Knierman MD, etal. (2002). "Tissue distribution and functional expression of a cDNA encoding a novel mixed lineage kinase". Journal of Molecular and Cellular Cardiology. 33 (9): 1739–1750. doi:10.1006/jmcc.2001.1437. PMID 11549352.
- Gross EA, Callow MG, Waldbaum L, Thomas S, Ruggieri R (2002). "MRK, a mixed lineage kinase-related molecule that plays a role in gamma-radiation-induced cell cycle arrest". Journal of Biological Chemistry. 277 (16): 13873–13882. doi:10.1074/jbc.M111994200 . PMID 11836244.
- Yang JJ (2002). "Mixed lineage kinase ZAK utilizing MKK7 and not MKK4 to activate the c-Jun N-terminal kinase and playing a role in the cell arrest". Biochemical and Biophysical Research Communications. 297 (1): 105–110. Bibcode:2002BBRC..297..105Y. doi:10.1016/S0006-291X(02)02123-X. PMID 12220515.
- Yang JJ (2003). "A novel zinc finger protein, ZZaPK, interacts with ZAK and stimulates the ZAK-expressing cells re-entering the cell cycle". Biochemical and Biophysical Research Communications. 301 (1): 71–77. Bibcode:2003BBRC..301...71Y. doi:10.1016/S0006-291X(02)02980-7. PMID 12535642.
- Takahashi M, Gotoh Y, Isagawa T, Nishimura T, Goyama E, Kim HS, etal. (2004). "Regulation of a mitogen-activated protein kinase kinase kinase, MLTK by PKN". Journal of Biochemistry. 133 (2): 181–187. doi:10.1093/jb/mvg022 . PMID 12761180.
- Cho YY, Bode AM, Mizuno H, Choi BY, Choi HS, Dong Z (2004). "A novel role for mixed-lineage kinase-like mitogen-activated protein triple kinase alpha in neoplastic cell transformation and tumor development". Cancer Research. 64 (11): 3855–3864. doi:10.1158/0008-5472.CAN-04-0201 . PMID 15172994.
- Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, etal. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–1450. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004年07月05日1 . PMID 15324660. S2CID 2371325.
- Tosti E, Waldbaum L, Warshaw G, Gross EA, Ruggieri R (2005). "The stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathway". Journal of Biological Chemistry. 279 (46): 47652–47660. doi:10.1074/jbc.M409961200 . PMID 15342622.
- Huang CY, Kuo WW, Chueh PJ, Tseng CT, Chou MY, Yang JJ (2004). "Transforming growth factor-beta induces the expression of ANF and hypertrophic growth in cultured cardiomyoblast cells through ZAK". Biochemical and Biophysical Research Communications. 324 (1): 424–431. Bibcode:2004BBRC..324..424H. doi:10.1016/j.bbrc.2004年09月06日7. PMID 15465036.
- Huang CY, Chueh PJ, Tseng CT, Liu KY, Tsai HY, Kuo WW, etal. (2004). "ZAK re-programs atrial natriuretic factor expression and induces hypertrophic growth in H9c2 cardiomyoblast cells". Biochemical and Biophysical Research Communications. 324 (3): 973–980. Bibcode:2004BBRC..324..973H. doi:10.1016/j.bbrc.2004年09月15日6. PMID 15485649.
- Choi HS, Choi BY, Cho YY, Zhu F, Bode AM, Dong Z (2005). "Phosphorylation of Ser28 in histone H3 mediated by mixed lineage kinase-like mitogen-activated protein triple kinase alpha". Journal of Biological Chemistry. 280 (14): 13545–13553. doi:10.1074/jbc.M410521200 . PMID 15684425.
- Wang X, Mader MM, Toth JE, Yu X, Jin N, Campbell RM, etal. (2005). "Complete inhibition of anisomycin and UV radiation but not cytokine induced JNK and p38 activation by an aryl-substituted dihydropyrrolopyrazole quinoline and mixed lineage kinase 7 small interfering RNA". Journal of Biological Chemistry. 280 (19): 19298–19305. doi:10.1074/jbc.M413059200 . PMID 15737997.
- Benzinger A, Muster N, Koch HB, Yates JR 3rd, Hermeking H (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Molecular & Cellular Proteomics. 4 (6): 785–795. doi:10.1074/mcp.M500021-MCP200 . PMID 15778465.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, etal. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
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