RRNA N-glycosylase
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(Redirected from RRNA N-glycosidase)
| rRNA N-glycosylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Ricin A chain, Ricinus communis | |||||||||
| Identifiers | |||||||||
| EC no. | 3.2.2.22 | ||||||||
| CAS no. | 113756-12-0 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
rRNA N-glycosylase (EC 3.2.2.22, ribosomal ribonucleate N-glycosidase, nigrin b, RNA N-glycosidase, rRNA N-glycosidase, ricin, momorcochin-S, Mirabilis antiviral protein, gelonin , saporins) is an enzyme with systematic name rRNA N-glycohydrolase.[1] This enzyme catalyses the following chemical reaction
- Hydrolysis of the N-glycosylic bond at A-4324 in 28S rRNA from eukaryotic ribosomes.
Ricin A-chain and related toxins show this activity. The only protein family known to have this activity is the ribosome-inactivating protein (RIP) family.
References
[edit ]- ↑ Endo Y, Tsurugi K (June 1988). "The RNA N-glycosidase activity of ricin A-chain. The characteristics of the enzymatic activity of ricin A-chain with ribosomes and with rRNA". The Journal of Biological Chemistry. 263 (18): 8735–9. doi:10.1016/S0021-9258(18)68367-X . PMID 3288622.
External links
[edit ]- RRNA+N-glycosylase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
