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Protein-coding gene in the species Homo sapiens
PCLAF Identifiers Aliases PCLAF External IDs OMIM : 610696 ; MGI : 1915276 ; GeneCards : PCLAF RNA expression patternBgee Human Mouse (ortholog) trabecular bone embryo ventricular zone ganglionic eminence bone marrow gingival epithelium thymus hair follicle bone marrow cell oral cavity yolk sac tail of embryo somite embryo ventricular zone genital tubercle embryo maxillary prominence mandibular prominence atrium More reference expression data
BioGPS
Wikidata
PCNA-associated factor (also called "P CNA cl amp a ssociated f actor") is a protein that in humans is encoded by the PCLAF gene (previously KIAA0101 ).[ 5] [ 6] [ 7] PCNA and regulates DNA repair during DNA replication.[ 8]
1 2 3 GRCh38: Ensembl release 89: ENSG00000166803 – Ensembl , May 20171 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040204 – Ensembl , May 2017↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .1 2 Yu P, Huang B, Shen M, Lau C, Chan E, Michel J, Xiong Y, Payan DG, Luo Y (Jan 2001). "p15(PAF), a novel PCNA associated factor with increased expression in tumor tissues" . Oncogene . 20 (4): 484– 9. doi :10.1038/sj.onc.1204113 PMID 11313979 . ↑ Simpson F, Lammerts van Bueren K, Butterfield N, Bennetts JS, Bowles J, Adolphe C, Simms LA, Young J, Walsh MD, Leggett B, Fowles LF, Wicking C (Jan 2006). "The PCNA-associated factor KIAA0101/p15(PAF) binds the potential tumor suppressor product p33ING1b". Experimental Cell Research . 312 (1): 73– 85. doi :10.1016/j.yexcr.2005年09月02日0 . PMID 16288740 . ↑ "Entrez Gene: KIAA0101 KIAA0101" .↑ "Q15004 · PAF15_HUMAN" . uniprot.org . UniProt consortium. Retrieved 2026年08月03日 .
Shi L, Zhang SL, Li K, Hong Y, Wang Q, Li Y, Guo J, Fan WH, Zhang L, Cheng J (Feb 2008). "NS5ATP9, a gene up-regulated by HCV NS5A protein". Cancer Letters . 259 (2): 192– 7. doi :10.1016/j.canlet.2007年10月02日9 . PMID 18068894 . Guo M, Li J, Wan D, Gu J (2006). "KIAA0101 (OEACT-1), an expressionally down-regulated and growth-inhibitory gene in human hepatocellular carcinoma" . BMC Cancer . 6 109. doi :10.1186/1471-2407年6月10日9 PMC 1483895 PMID 16646990 . Mizutani K, Onda M, Asaka S, Akaishi J, Miyamoto S, Yoshida A, Nagahama M, Ito K, Emi M (May 2005). "Overexpressed in anaplastic thyroid carcinoma-1 (OEATC-1) as a novel gene responsible for anaplastic thyroid carcinoma" . Cancer . 103 (9): 1785– 90. doi :10.1002/cncr.20988 PMID 15789362 . Petroziello J, Yamane A, Westendorf L, Thompson M, McDonagh C, Cerveny C, Law CL, Wahl A, Carter P (Oct 2004). "Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer" . Oncogene . 23 (46): 7734– 45. doi :10.1038/sj.onc.1207921 PMID 15334068 . Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1" . DNA Research . 2 (1): 37– 43. doi :10.1093/dnares/2.1.37 PMID 7788527 .
