GNGT1
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(Redirected from GNGT1 (gene))
Protein-coding gene in the species Homo sapiens
| GNGT1 | |||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | GNGT1 , GNG1, G protein subunit gamma transducin 1, HG3G1 | ||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 189970; MGI: 109165; HomoloGene: 7738; GeneCards: GNGT1; OMA:GNGT1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||
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Guanine nucleotide-binding protein G(T) subunit gamma-T1 is a protein that in humans is encoded by the GNGT1 gene.[5] [6] Either GNGT1 or GNGT2 is the gamma subunit (Gγ) of the Gβγ part of transducin (written G(T) or Gt), a heterotrimeric G-protein naturally expressed in vertebrate retina rod and cone cells. GNGT1 only occurs in rod cells, and GNGT2 only occurs in cone cells, with a different alpha (Gα) subunit.[7] [8]
References
[edit ]- 1 2 3 GRCh38: Ensembl release 89: ENSG00000127928 – Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029663 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Scherer SW, Feinstein DS, Oliveira L, Tsui LC, Pittler SJ (September 1996). "Gene structure and chromosome localization to 7q21.3 of the human rod photoreceptor transducin gamma-subunit gene (GNGT1)". Genomics. 35 (1): 241–243. doi:10.1006/geno.1996.0346. PMID 8661128.
- ↑ "Entrez Gene: GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1".
- ↑ Lagman D, Sundström G, Ocampo Daza D, Abalo XM, Larhammar D (October 2012). "Expansion of transducin subunit gene families in early vertebrate tetraploidizations". Genomics. 100 (4): 203–211. doi:10.1016/j.ygeno.201207005. PMID 22814267.
- ↑ Lerea CL, Somers DE, Hurley JB, Klock IB, Bunt-Milam AH (October 1986). "Identification of specific transducin alpha subunits in retinal rod and cone photoreceptors". Science. 234 (4772): 77–80. Bibcode:1986Sci...234...77L. doi:10.1126/science.3529395. PMID 3529395.
Further reading
[edit ]- Simonds WF, Butrynski JE, Gautam N, Unson CG, Spiegel AM (March 1991). "G-protein beta gamma dimers. Membrane targeting requires subunit coexpression and intact gamma C-A-A-X domain". The Journal of Biological Chemistry. 266 (9): 5363–5366. doi:10.1016/S0021-9258(19)67601-5 . PMID 1706334.
- Ray K, Kunsch C, Bonner LM, Robishaw JD (1995). "Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits". The Journal of Biological Chemistry. 270 (37): 21765–21771. doi:10.1074/jbc.270.37.21765 . PMID 7665596.
- Tao L, Pandey S, Simon MI, Fong HK (1993). "Structure of the bovine transducin gamma subunit gene and analysis of promoter function in transgenic mice". Experimental Eye Research. 56 (4): 497–507. doi:10.1006/exer.1993.1063. PMID 8500562.
- Yan K, Kalyanaraman V, Gautam N (1996). "Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families". The Journal of Biological Chemistry. 271 (12): 7141–7146. doi:10.1074/jbc.271.12.7141 . PMID 8636150.
- Gaudet R, Savage JR, McLaughlin JN, Willardson BM, Sigler PB (May 1999). "A molecular mechanism for the phosphorylation-dependent regulation of heterotrimeric G proteins by phosducin". Molecular Cell. 3 (5): 649–660. doi:10.1016/S1097-2765(00)80358-5 . PMID 10360181.
- Xu S, Ladak R, Swanson DA, Soltyk A, Sun H, Ploder L, etal. (December 1999). "PHR1 encodes an abundant, pleckstrin homology domain-containing integral membrane protein in the photoreceptor outer segments". The Journal of Biological Chemistry. 274 (50): 35676–35685. doi:10.1074/jbc.274.50.35676 . PMID 10585447.
- Marin EP, Krishna AG, Zvyaga TA, Isele J, Siebert F, Sakmar TP (January 2000). "The amino terminus of the fourth cytoplasmic loop of rhodopsin modulates rhodopsin-transducin interaction". The Journal of Biological Chemistry. 275 (3): 1930–1936. doi:10.1074/jbc.275.3.1930 . PMID 10636894.
- Cuello F, Schulze RA, Heemeyer F, Meyer HE, Lutz S, Jakobs KH, etal. (February 2003). "Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta". The Journal of Biological Chemistry. 278 (9): 7220–7226. doi:10.1074/jbc.M210304200 . PMID 12486123.
- Hinrichs MV, Montecino M, Bunster M, Olate J (2005). "Mutation of the highly conserved Arg165 and Glu168 residues of human Gsalpha disrupts the alphaD-alphaE loop and enhances basal GDP/GTP exchange rate". Journal of Cellular Biochemistry. 93 (2): 409–417. doi:10.1002/jcb.20193. PMID 15368366. S2CID 85626429.
- Gao X, Sadana R, Dessauer CW, Patel TB (2007). "Conditional stimulation of type V and VI adenylyl cyclases by G protein betagamma subunits". The Journal of Biological Chemistry. 282 (1): 294–302. doi:10.1074/jbc.M607522200 . PMID 17110384.
- Seo M, Lee MJ, Heo JH, Lee YI, Kim Y, Kim SY, etal. (August 2007). "G Protein betagamma subunits augment UVB-induced apoptosis by stimulating the release of soluble heparin-binding epidermal growth factor from human keratinocytes". The Journal of Biological Chemistry. 282 (34): 24720–24730. doi:10.1074/jbc.M702343200 . PMID 17548351.
External links
[edit ]- Overview of all the structural information available in the PDB for UniProt : P02698 (Bovine Guanine nucleotide-binding protein G(T) subunit gamma-T1) at the PDBe-KB .
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